Archive for April, 2009

Seeding the GI Tract

bio1
April 29th, 2009

Can you name this Beautiful Creature?

Dear Friends,

Seeding the gastrointestinal tract with good bacteria is smart medicine. It is a critical component to achieving and maintaining good health. In this email I will share with you some of the thinking that has gone into the criteria we have used in the selection of certain bacterial strains for our synbiotic formulas.

Let’s look at the criteria for selecting our probiotic organisms:

Historical usage: For 10,000 years humans have consumed fermented foods. Good bacteria have mixed with foods and fermentation occurs providing the likes of kimchi, miso, kefir, cheese, bread and alcohol. In most cases, more than one organism, or groups of organisms are involved in the fermentation.

For example in the manufacture of Swiss cheese thermophilic lactic acid bacteria from two different genera are required to ferment lactose, produce lactic acid and acidify the cheese to pH 5.2—a task that takes 18 hours. Another example of lactic acid species working together is in starter cultures that use L. bulgaricus and S. thermophilus: yogurt made with only one of these two organisms will not turn out well. It has long been known that the above bacteria grow faster and perform better when grown as a pair, compared to when they are grown separately. The S. thermophilus always appears to grow first in co-cultures; the initial milk environment is less conductive for L. bulgaricus as it takes the thermophilus to lower the pH to levels preferred by bulgaricus. The bulgaricus can grow and helps the thermophilus, as bulgaricus has more proteolytic enzymes and can supports the thermophilus with its amino acid needs. Synergy at work.

In the early 1900s Eli Metchnikoff, the Russian Zoologist and Nobel laureate, considered to be the “Father of probiotics research”, identified and made famous bulgaricus and thermophilus in his classic study on the factors involved in longevity and his subsequent book, The Prolongation of Life. He sited the regular consumption by the Bulgarian people of kefirs and yogurts created through the use of bulgaricus and thermophilus cultures as the key factor in enabling the Bulgarian people to be acclaimed as the society with the most people over 100 years old.

The genus Lactobacillus consists of more than 80 species. In the last decade, microbial taxonomists have been very busy, proposing and validating new taxa. In one single month (January 2005) seven new species and subspecies were described in microbiology published literature. The Lactobacillus genus is ubiquitous and occupies a wide range of habitats. They are normal inhabitants of plant and vegetable material, frequently found in dairy and meat environments, and in grains and cereals. Plus as we have said the Lactobacillus genus is the most common organisms used in fermented foods worldwide. Their presence in the animal and human gastrointestinal tract (as well as in the stomach, mouth. and vagina) has led to their common use as a probiotic. Our bodies have evolved with them.

Acid and bile resistance: Because we are selecting organisms for the gastrointestinal tract, they must be able to pass through the acid and bile barrier of the stomach and small intestines respectively. The strains we have selected are acid and bile tolerant, enabling their arrival into the small and large intestines alive and ready to grow and provide their probiotic benefits.

Adhesive properties: Adhesive properties are important for the bacteria to be able to stay around in the intestines longer, thereby providing continued synbiotic benefits. Seven out of nine of our BioImmersion selected ATCC lactic acid organisms are colonizing bacterium (save the above bulgaricus and thermophilus which are both transient; meaning that they don’t colonize and must be consumed regularly). The colonizing beneficial bacteria we provide are able to take up receptor sites on the membrane, preventing toxic and pathogenic organisms from doing so.

Acidify the membrane: All of the organism in our synbiotic formulas (L. casei, L. plantarum, L. rhamnosus, L. helveticus, L. bulgaricus, S. thermophilus, B. longus and B. infantis) are strong lactic acid producers, except for the L. acidophilus, which has many other beneficial attributes including being a strong colonizer. Thermophilus and bulgaricus are two of the strongest producers of lactic acid. Acidifying the bolus of food helps in the digestion of proteins. Acidifying of the GI tract membrane facilitates the absorption of minerals, and protects the membrane from pathogens.

Production of bacterocins: All of our BioImmersion probiotic strains were selected for their ability to produce a wide variety of bacterocins (antibiotic like substances) that enables the collection to inhibit and keep-at-bay pathogenic gut organisms.

Special specific properties: Each probiotic organism has its unique set of benefits that it provides (See the Library Tab on the BioImmersion website for details on each organism). The L. helveticus for example produces three peptides that are ACE inhibitors. They lower blood pressure! Lactobacillus helveticus is a good colonizer so these effects can be maintained more consistently.

Inhabiting and protecting different regions: We recommend mixing and matching our synbiotic formulas to get a wide variety of the BioImmersion strains inhabiting the specific regions of the gastrointestinal tract that are their particular niche; thereby achieving a more complete membrane coverage. For example the Bifiodbacterium genus (as in our B. longum and B. infantis) are obligate anaerobes meaning that they only grow and colonize the large intestines. They are the major contributing colonic probiotic organism producing copious amounts of lactic acid, bacterocins, and colonizing and protecting the membrane. The Lactobacillus genus can and do grow in the large intestines but don’t have the saying power in the colonic ecosystem as do the Bifido species; and, are more organisms of the small bowel intensifying in numbers as they approach the region of the ileocaecal valve.

As I have been presenting in this series of emails that began last September, we are living in biologically stressful time for the human species: and that the process of de-evolution is underway. Chronic illness is becoming a given and pandemics are a very real and probable threat. We have all become jaded to the over hyped media and can put the current Swine Flu scare into that category, thinking it really isn’t that bad and that it couldn’t happen to us. But unfortunately it is the very thing that the de-evolutionary process would predict to happen; our global human population has become so weakened immunologically and pathogens have become more virulent, that a pandemic is a very real possibility.

It is the reason we have put our strong synbiotic formulas together.

Sincerely yours,

Seann Bardell

BioImmersion.com

Clinical Note: I would suggestion taking anyone of our seven synbiotics formulas on a regular basis; to establish it as a regular part of your recommended patient protocols. Also consider mixing the different strains over time. Why not start with something like the Supernatant Synbiotic Formula which has seven pedigreed Bulgarian strains, plus supernatant (the freeze dried metabolites of S. thermophilus, L. bulgaricus and B. infantis) and organic inulin). Take one capsule a day. Plus why not add one capsule daily of our Organic Freeze Dried Garlic. This is very powerful protection.

This beautiful creature is an Artic Fox

The Last Quiz Answer: This beautiful creature is an Artic Fox.


At the turn of the twentieth century the world experienced the Spanish Flu. It killed an estimated 50 million people worldwide (800,000 in America); the worst pandemic in recorded history. It accomplished its ravaging in just one year affecting mostly people between the ages of 20 to 40. We have a right to be concerned.

Veratect Inc. was established in 2007 to provide the earliest detection of potential threats to human, animal and plant life. Its public health experts and regional analysts incorporate data from more than 40,000 original sources in more than 30 languages for the company’s unique 24 hour tracking and comprehensive reporting services. The methodology targets local sources, which often report the signs of disease outbreaks before being officially diagnosed. They are the company that has first alerted the world to this present Swine Flu concern. Their data is available for all to see over the internet.

Probiotic Naming Shenanigans

bio1
April 22nd, 2009

Can you name this Beautiful Creature?

Dear Friends,

Nomenclature, when it comes to bacteria, can be very confusing; partly because of the evolving technology for classifying organisms, which necessitates giving them new names corresponding to their new group identity, and partly because of the private sector corporate shenanigans, motivated by profit and name recognition.

Let’s take a look at the use of the word bacillus: The word bacillus can be confusing because it can refer to the Genus Bacilli of a particular bacterium or to the Class Bacilli of a particular group of bacterium in the Phylogenetic Tree. Notice that the Genus Bacilli are always italicized, while the class is not. As we discussed in earlier emails, the Phylogenetic Tree of Life (based on 16S rRNA sequences) is divided into three Domains of life: Eukaryota, Archeae and Bacteria. From the Eukaryota branch of life all plants and animals have descended, including fungi, whereas, from the Archeas branch we get a microbial world that live in extreme environments such as in volcanoes and the Arctic, and from the Bacterial branch evolved bacteria, such as probiotic. According to the most current taxonomy, bacteria are then divided into twenty-four different Phyla— Firmicutes, Bacteroidetes, Proteobacteria, Cyanobacteria, Spirochaetes, etc.

>From Phyla, bacteria are then divided into Classes by classification according to shape. Most bacteria come in one of three basic shapes: Cocci (i.e.  Streptococcus thermophilus), Bacilli (i.e. Lactobacillus acidophilus), and Spirochaetes (i.e. Borrelia burgdorferi). The Cocci are spherical or oval shaped bacteria, the Bacilli are rod shaped organisms, and the Spirochaetes are spiral shaped organisms.

As we continue to subdivide and go from Class to Order to Genus to Species to Subspecies or Strains, it can get quite confusing. In the world of probiotic supplementation, bacteria from the Lactobacillus and Bifidobacterium Genuses are the most commonly used organisms. Bacteria from the Genus Bacillus are also used, though less frequently.

All of the bacteria within the Bacillus Genus are spore-forming organisms, whereas the Lactobacillus and Bifidobacterium Genus organisms are not. The Class Bacilli contains both the Genus Bacilli and the Genus Lactobacillus because they are all rod shaped organisms. To say all Bacilli are spore-forming organisms depends on whether you are talking about the Class or the Genus— confusing a little?

A good example of the nomenclature confusion concerns the organism Lactobacillus sporogenes. This name can be traced to a paper published in 1932 (Horowitz-Wlassowa and Nowotelnow1932). However, since the bacterium described in the paper was a spore-forming bacterium, it could not be considered a species within the genus Lactobacillus. It has been correctly reclassified as Bacillus coagulans, clearly denoting the bacteria as a soil organism. Unfortunately, it does not stop some companies, even today, from using the old name Lactobacillus sporogenes for the Bacillus coagulans soil organism, adding to the confusion and perhaps desiring to capitalize on the much wider scientific coverage for probiotic effectiveness attributed to the Genus Lactobacillus.

There are other examples of nomenclature scientific violations regarding the Baccilli Genus. A recent analysis of several studies demonstrated that out of 7 probiotic products, none were labeled with the correct taxonomic description for the spore-forming soil bacteria contained as an active ingredient.

Product On label Identified as Reference
Enterogenrmina (Italy) B. subtilis B. clausii Green and others 1999
Lactipan plus (Italy) L. sporogenes B. subtilis Hoa and others 2000
Domuvar (Italy) B. subtilis B. clausii Hoa and others 2000
Bactisubtil (France) B. subtilis B.cereus Hoa and others 2000
Subtyl (Vietnam) B. subtilis a new species Hoa and others 2000
Biosubtil Dalat (Vietnam) B subtilis B. cereus Hoa and others 2000
Biosbtil Nha Trang B. subtilis B. pumilus Green and others 2000

Many companies are marketing the beneficial use of Bacillus and other spore-forming bacteria in concentrated dosages, yet there is not enough research to support safety or efficacy. Companies utilize the temperature resistance of the spores in order to make shelf-stable claims. The research on the soil organism of the Genus Bacillus as a human probiotic is spotty. Although probiotic research with Lactobacilli and Bifidobacteria has progressed quite steadily, we are still encountering several nomenclature issues, with the most egregious being the private corporate naming and attempts to patent living organisms.

Under the guise of corporate trade secrets, strains are named not with the universal, scientifically recognized nomenclature, but named with corporate trade names unique to that corporation. What this means is that the corporation alone knows the organism’s true identity. For example, Lactobacillus GG is a popular organism. In fact you have probably heard of it. But exactly what species of bacterium is GG? Do you know?

It turns out that LGG is a strain of L. rhamnosus isolated in 1983 from the intestinal tract of a healthy human being; filed for patent on 17 April 1985, by Sherwood Gorbach and Barry Goldin. The GG derives from the first letters of their surnames. The GG strain has been identified as ATCC 53103 by ATCC (the American Type Culture Collection), which is the largest repository for bacteria in the world, and is the scientific gold standard for taxonomy along with other key repositories around the world— the European culture collections (DSWMZ, LMG, CIP and NCIMB) or Japanese collection (IAM). With the correct nomenclature given to organisms, scientists from around the world can more efficiently and accurately progress in their research as everyone knows exactly what they are working with and can easily share the information.

The reality is that effective probiotic organisms go under many aliases. As an example of how private corporate gain name recognition and forsake scientific protocol, lets take our Original Synbiotic Formula which is composed of five lactic acid organisms, one of which is Lactobacillus acidophilus ATCC 4356. XYZ Company has given our Original Synbiotic Formula to a few patients with irritable bowel syndrome with good results. XYZ Company then collects one of the patient’s stool samples, cultures the organisms and identifies an acidophilus strain that comes from the Original Synbiotic product. Legally, they can now create a mother culture of this L. acidophilus, produce it in large volumes and sell it as their own special xyz strain of Lactobacillus acidophilus; giving it their own corporate name as a part of the identification of the strain; inferring that they are the only one who has this “particular” probiotic strain. This behavior is not only counterproductive to the process of discovery and progress in medicine but is down right unscientific, yet that is the reality and facts of the probiotic world as we know it. Read further on BioImmersion Taxonomy Campaign http://www.bioimmersion.com/tech3.htm.

The Human Genome Project (HGP) set a marvelous example for how much can be accomplished quickly when we share our knowledge and not hide it. The NIH Human Genome team was able to complete the total human genome sequencing decades before scientists thought possible because HGP made the genomic sequencing an open process. As sequences (segments) were determined, they were shared openly over the Internet enabling scientists worldwide to learn and add their sequencing discoveries. The result— all 3 billion base pairs of the human genome were mapped by 2003.

Now, part of the Human Genome Project team has morphed into the Human Microbiome Project, and with the same m.o. are focused on the typing of the human microbiome. Is it not time for the probiotic corporate world to put aside their perceived need for secrecy as the vehicle for successful marketing? It is time for clear open nomenclature for the sake of medicine and progress. Look at the bottle of probiotic you are using: What is the strain designation and name of the organism? Ask for the scientific universal identification of the probiotic organism you use in your practice. Can living creatures belong to corporations? Of course not. Lets be a part of the solution and progress in the probiotic world.

Sincerely yours,

Seann Bardell

BioImmersion.com

Clinical Note: The Triple Berry Probiotic Formula is a combination of two lactic acid organism plus three berries. The organism are ATCC identified and classified as Lactobacillus acidophilus ATCC 4356 and Bifidobacterium longum ATCC 15707. Triple Berry combines the strength of extensive research on berries and probiotic for brain and gut protection, prevention of cancer with high ORAC value, and anti-inflammatory properties. The Triple Berry can be utilized as a foundational probiotic product as well as the needed Blueberry daily dosage for defogging the brain and sharpening the mind. The Raspberry has broad-spectrum antimicrobial benefit, while the Cherry helps with inflammation and pain. Great foundational product for children and adults.

Human Baby from Indonesia

The Last Quiz Answer: This is a human baby from Indonesia.



We’ve long known that a child exposed to lead in the womb or in his or her first six years is susceptible to permanent brain damage, and more recent research has shown that this damage extends to the heart and cardiovascular system as well. Read more at The Daily Green: Click Here

Children as Canaries in Mines

bio1
April 15th, 2009

Can you name this Beautiful Creature?

Dear Friends,

Remember a couple of emails ago we sited frogs as being the canary in the mine? The common herbacide, atrazine, causes hermaphroditism 100% of the time when exposedto even very small dosages. Atrazine stimulates an enzyme called aromatase, which converts the male hormone testosterone into the female hormone estrogen.

In the U.S. today, we use an astounding 2.2billion pounds of pesticides a year.
That is thirty times more pesticides than our great grand parents used in 1945. Some estimates say that 90% of American homes use pesticides. They are certainly common in homes, schools, daycare centers, parks, and virtually every place with a little grass or vegetation. The most common types are neurotoxic, and because of a child’s lower weight, more rapid breathing and increased hand-to-mouth behavior, their exposure to toxins far exceeds that of an adult. Our children are the canary.

Lets take a look at how chemicals and pollution affect our children:

• Neuroblastoma, a form of childhood cancer, accounts for 10% of all childhood cancers and it has been linked to pesticide exposure. A study in 2001 reported that using pesticides in and around the home increased children’s risk of developing neuroblastoma by 60%.

• In 1998 The American Journal of Industrial Medicine published the result of an analysis of five previous studies showing that women exposed to organic solvents during pregnancy have an increased risk of giving birth to a baby with a major birth defect by 64%. The analysis took place 11 years ago—how many more chemicals are we using today?

• A recent study in JAMA found that women exposed to toxins during pregnancy had a 13 fold increased risk of giving birth to a child with a major birth defect, including heart valve defects, micro-penis, deafness, kidney defect, low birth weight and soft cartilage in the larynx.

• Small amounts of bisphenol A (BPA) can damage cells, causing them to become
more subject to aneuploidy, a condition that causes birth defects in children. The most common form of meiotic aneuploidy in live-born humans is trisomy 21, found in Down syndrome. Trisomy meaning three copies instead of two of chromosome 21. See the karyotype below, with the twenty-two pairs of chromosomes arranged from the largest to smallest. The 23rd pair being the sex chromosomes.

Sex Chromosomes

• Six billion pounds of BPA are made each year. It is the backbone of polycarbonate plastic used for reusable food and beverage containers, and is used also as an epoxy resin that lines most metal food cans. BPA leaches from containers into our food and beverages and virtually everyone in the developed world is exposed to this chemical. Nearly all of us have blood levels of BPA within the range that is predicted to be biologically active.

• BPA causes increases in breast and prostate cancer, increases in urogenital abnormalities in male babies, a decline in semen quality in men, early onset of puberty in girls, metabolic disorders including Type 2 diabetes and obesity, and ADHD.

• Polybrominated Diphenyl Ethers, a chemical cousin to PCBs, is a flame retardant added to mattresses, carpet paddings, vehicle upholstery and electronics. In test animals PBDEs cause thyroid hormone disruption, permanent learning and memory impairment, behavioral changes, hearing deficits, delayed puberty onset, decreased sperm count and fetal malformations. It is stored in fatty tissue and can be passed on to fetuses and infants during pregnancy and lactation.

We have just looked at three categories of de-evolutionary pollutant: pesticides, organic solvents and plastics, and it is just the tip of the iceberg. The assault of toxic chemical, heavy metals, herbacides, and pesticides is impacting children’s bodies. Conditions such as hormone disruption or neurological symptoms are the very signs and indication of the de-evolutionary process. At the end of the day, when we speak of de-evolution, we are taking in account the evolution or de-evolutionof the whole biosphere. The evolutionary process has led us to the mammals and human species, whereas the de-evolutionary process is taking us backward in the direction of simpler forms of life by the elimination of the higher forms. Evolution is the forward movement of any species; getting stronger and more able to survive, improving the ability to produce vibrant, smarter offspring, with enhanced attributes; physically and mentally. We can see this process happening to “Super bugs”; their offspring are able to survive tougher conditions. Our children on the other hand, are experiencing a pandemic of chronic illness, impaired neurological functions and a host of complicated maladies. The planet is not a hospitable environment for our children to thrive and flourish in any more. We need a planet wide “make-over”.

Sincerely yours,

Seann Bardell

BioImmersion.com

Clinical Note: There is no such a thing as a neutral existence on earth: we either thrive or we decay. We either evolve or we de-evolve, depending on the conditions around us and within us. The Therapeutic Foods Line is foundational for turning the body back into a repair and healing mode, awakening the body’s natural responses to do the functions it needs to do for survival. Start your child’s day with a Triple Berry to protect the brain and the microbiome, neutralize free radicals, add the Cruciferous Sprouts Complex three times a week to clean and detoxify the blood and liver.

The Therapeutic Food Platform Webinar- join us. Each Thursday and Friday at 9:30 am and again at 12:30 pm (PST) we present a half-hour overview of the Therapeutic Foods, how they are produced, foundational protocols and synergistic combinations. It is a great practical overview! Simply call or email us as to the session you would like to attend and we will email you the link.

Bifidobacterium

The Last Quiz Answer: Did you guess Bifidobacterium? Good job. There are more than twenty-five recognized species of Bifidobacterium although only about ten are ordinarily used  commercially as probiotics. These include: Bifidobacterium bifidum, Bifidobacterium adolescentis, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium lactis and Bifidobacterium longum. Bifidobacteria are gram positive, non-motile, non-sporing rods with a high G+ C content (55% to 67 mol%).

This green fact takes you to an exercise in human karyotyping using digital images of chromosomes from actual human genetic studies. Karyotype analyses are performed over 400,000 times per year in the US and Canada; the conclusion of which can have profound affect on lives. Good luck!!

http://www.biology.arizona.edu/human_bio/activities/karyotyping/karyotyping.html

Hoodlums in the Gut

bio1
April 7th, 2009

Can you name this Beautiful Creature?

Dear Friends,

It has been said that we are as good as the company that we keep, and indeed from a Lilliputian point of view, our body keeps company with many different cells, and it is the balance of good-bad cells that moves us forward or backwards in the evolutionary ladder. We are composed of a collection of human cells and microbial cells, living on us and within us, intimately—in communication with our human cells. Our gut, like New York City, is a melting pot of cellular life, a vast milieu of expressed proteins, all with a specified function. Our health is reflected by the health of the microbiome, the inter-play pattern of the proteins, intermixing in the gut and throughout the body. Today we will look at the neonate, the most vulnerable amongst us.

Lets review an important aspect of our existence: we have previously learned that 60 tons of food passes through our gut in a lifetime! Due to the increasingly toxic nature of our environment, a rising amount of toxic and pathogenic materials goes through our gastrointestinal tract, and is in intimate contact with us. Our health is always a balance between the forces that support our survival and those that are programmed to destroy it. De-evolution is the result of the increased numbers of toxic materials: hormone disruptors, carcinogens, respiratory toxins, reproductive/developmental toxins, neurotoxins, iimmuno-toxins and unchecked pathogenes—materials and organisms that need to be nuturalized and inhibited with supportive and detoxifying live-cells inputs.

So it makes much sense to diligently bring into our gut the extra army we need to fight the good fight and balance the power on the side of our good survival.

At birth an infant’s intestine is initially colonized by complex flora that reflects maternal vaginal and large intestinal flora. Breast milk is the first source of bacteria such as Lactobacillus and Bifidobacteria, which compete with pathogens. The mode of birth, surrounding environment, and dietary factors influence initial gut colonization in a neonate.

What can be more delicate that a pre-term baby? Necrotizing enterocolitis (NEC) is a significant cause of mortality and morbidity for these very low weight newborns. NEC is a multifactor disease that results from an interaction between the loss of mucosal integrity (due to ischemia, inflammation and infection) and the host response to that injury (in the form of circulatory, inflammatory and immune-mediated response). The most common risk factors cited are colonization by bacteria such as Escherichia coli, Klebsiella, Clostridium perfringes, Staphylococcal epidermis and Rotavirus. To save the newborn lives, a mix of Bifidobacterium longum, Bifidobacterium infantis, Bifibobacterium bifidum and Lactobacillus acidophilus was given, resulting in reversal of condition and healthy growth. See Green Facts for details.

Other neonatal research clearly show that creating the right microbiome community can save lives, and bring about a healthy state. It is important to develop the correct microbiome population early on in life, and continue to guard the balance of the negative and positive organism living on us and within us.

Sincerely yours,

Seann Bardell

BioImmersion.com

Clinical Note: Therapeutic Foods Synbiotic Formulas for infants. Both the Original Synbiotic Formula and the Supernatant Synbiotic Formula have been used by our pediatric doctors – with great success. If the infant is not on solid food, simply putting a small amount of the power on your finger for the infant to suck will suffice! It is that easy to bring in the good bugs.

Reef

The Last Quiz Answer: The Remoras seen on the underbelly of this magnificent mother humpback whale is classified relationally as a commensal, not a symbiot. In a symbiotic relationship both organisms in the relationship benefit. In a commensal relationship one organism benefits and the other organism neither gains nor looses anything. In this commensal relationship the remora hitches a ride on the humpback, is protected from harm and gets tidbits of the food it needs for survival from the humpbacks feedings.

Man and Remora

Man and remora enjoying an outing.

In the Journal of Tropical Pediatrics Moumita Samanta et al present an exciting study entitled, Prophylactic Probiotics for Prevention of Necrotizing enterocoltis in Very Low Birth weight Newborns. http://tropej.oxfordjournals.org/cgi/content/abstract/55/2/128

I Can't Work Because Of My Panic

bio1
April 1st, 2009

By Robert Anderson MD, ABIHM Executive Director

Tom came to me as the seventh physician whom he had seen in two and one-half years. At 31, he had first seen his family doctor for attacks of anxiety, pounding heart, shortness of breath and sweating. These symptoms were unrelated to meals or any other consistent exposure that anyone had figured out. He was treated with Xanax (a tranquilizer like valium) with partial relief of symptoms. He was referred to an internal medicine specialist who found a normal blood sugar and diagnosed his condition as “panic attacks.” Tom was treated with a beta-blocker (a drug like Inderal to slow down the fast heart rate which accompanies panic attacks). This did not relieve his anxiety, fidgeting and restlessness. He saw an endocrinologist who concluded after numerous tests that his thyroid was functioning normally and suggested that he might wish to see a psychiatrist. During this time he grew steadily worse and found it difficult to finish a complete week of work at his job in a machine shop located on the waterfront in Seattle. After being on the beta-blocker for some time, he began to have a distinctly diminished sex drive and poor quality erections, a known side effect of beta blockers.

Through several months of psychotherapy, he continued to grow worse and increased his dose of Xanax to the highest levels suggested in the Physician’s Desk Reference. He had seen a Chiropractor and later an Acupuncturist before coming to see me.

I carefully combed his history for any clues his previous physicians might have missed. Responding to my meticulous questioning, Tom volunteered the curious observation that he never had any of his panic spells on Saturday afternoon or evening, Sunday morning or evening, or Monday morning. He also related growing steadily worse as the week progressed, with Friday always being by far his worst day. By Saturday afternoon he always had begun to feel better! Further, he had improved during each of his last three one-week vacations, which he attributed to being away from the stress of work and heavy highway traffic. Perhaps he was having a problem related to his work ? handling stress poorly, or perhaps he was reacting to something in his environment. He described being consistently exposed to a variety of chemical fumes. He had begun his job in the machine shop about three months before his panic spells began. His initial responsibilities on the job included clean-up in which he used a variety of cleaning materials and solvents in various areas of the shop.

I asked him to follow a protocol which I put in writing. He was to try to arrive early at work in time to check and record his pulse after sitting quietly in his truck for ten minutes before clocking in. I asked him to also take his pulse on leaving work after he had been sitting quietly in his truck for ten minutes without activity or listening to the radio. He followed the suggestions and kept a written record of his pulses morning and evening.

For each of the first two weeks of his records, his morning pulse rose steadily from sixty on Mondays to eighty-five on Fridays; the afternoon pulse rose from 75 on Mondays to 105 on Friday. After the second week of these results I persuaded him that he needed time away from work. He had scarcely any accumulated sick leave or accrued vacation. He filed a claim with the state Department of Labor and Industries for injury on the job. As part of his treatment I recommended a leave-of-absence. The problems of his rejected claim with state industrial insurance constitute another whole story.

Blood specimens were submitted to a toxicology laboratory in Texas to attempt to identify the chemicals to which he seemed to react, but the results were equivocal and not definitive. Over a six week unpaid leave from work he improved steadily and his beta-blocker drug was tapered and eliminated. His Xanax had to be reduced very slowly to avoid the emergence of bothersome and serious symptoms of withdrawal. It was very likely he had become habituated to it. With the addition of biofeedback, relaxation training and several cognitive-centered counseling sessions, he ceased having all panic spells and decided not to return to his old job.

Was his problem stress? Six weeks with no work or pay and a search for a new job without chemical exposures were certainly stressful enough. He continued to steadily improve during this time, and it appeared that his symptoms were related to exposure to solvent chemicals to which he had become sensitive. His freedom from panic spells led me to believe this was an environmental sensitivity and not stress related.

It was quintessential that someone spend enough time with him to provide the space in which he could report what he had observed about the pattern of his symptoms. As the saying goes, “the devil is in the details.” In his case, the answer was in the miniscule details.

Sidebar:
In our modern era of “Better Living Through Chemistry,” thousands of chemicals have been introduced into industrialized countries. It is important to remember that most of our “first world” degenerative diseases – coronary heart disease, cancer, diabetes, brain deterioration, etc. – are extremely rare or completely unknown in ‘primitive’ indigenous societies. Historical studies have confirmed the arrival of many of these degenerative diseases in “primitive” cultures only a few years after introduction of our “Western” lifestyle including our chemicals.

These chemicals lace our food, pollute our air and saturate our water supplies. Newspaper headlines often announce a scientific study which has revealed a new chemical offender which makes people ill or causes death. Lead is found in toys from China. Chlorination of water benefits us by killing most potentially harmful germs, but combines with organic residues to form organohalides which induce a higher level of bladder and rectal cancer in those who consume chlorinated water.

The field of environmental medicine grows increasingly more complex as our chemical environment multiplies the incidence of human reactions to chemical agents. Using filters for cooking and drinking water is a helpful initiative, and consuming organic food sources within a few days reduces the load of pesticides and herbicides found in the body.

Meet the Human Microbiome Project

bio1
April 1st, 2009

Can you name this Beautiful Creature?

Dear Friends,

The scientific method develops a hypothesis and then backs it up with objective, repeatable evidence. We will be looking at some of the hypotheses posited by the Human Microbiome Project and illustrate in a practical manner how we incorporate the research into the Therapeutic Foods synbiotic formulas.

One key concept is embodied by the word, redundancy. The hypothesis that has been expressed is that the multiple functions the microbiome performs for its human host, (such as helping to digest foods, producing vitamins, bacterocins, and biosurfactants, positively changing the underlying immune system, helping to create tolerance, producing lactic acid and neutralizing certain toxins), is accomplished by a wide variety of different species of lactic acid bacteria that have similar suites of genes; producing the same proteins to get the job done. Functional redundancy makes sense from an evolutionary point of view for the human host’s survival, for if a phage attack kills one species of the host’s beneficial flora – another species can stand in, producing the necessary enzymes. At BioImmersion, in our own work of formulating synbiotic formulas, we have incorporated the concept of redundancy.

Cancer is now the number one killer in American; and, gastro-intestinal, breast and prostate cancers are right on top of that list. In a lifetime the average American consumes 60 tons of food, and our food is increasingly filled with toxins and pathogens as it comes from all corners of the world. Heterocyclic amines are unequivocally GI tract mutagens and carcinogens; in fact, they have also been implemented in breast and prostate cancers as well. Where do they come from? How do we get them in our gut?

When we fry, broil, and barbeque red meat, the amines in the meat are converted into heterocyclic amines. So, one way to prevent this occurring, of course, would be to stop eating red meat cooked under these conditions. Another way, however, is to make sure that you have protective friends in your GI tract that can neutralize these compounds when they are created. In developing our Original Synbiotic Formula this was one of the major criteria selected for. Can the bugs we select neutralize heterocyclic amines?

The five strains (subspecies) we chose for the Original Synbiotic Formula were selected to protect, counteract and neutralize dietary toxins, mutagens, carcinogens and infectious organisms. In particular, regarding the neutralizing of heterocyclic amine, all five organisms chosen have that ability. They are: Lactobacillus acidophilus (ATCC 4356), Bifidobacteria longum (ATCC 15707), Streptococcus thermophilus (ATCC 19258), Lactobacillus rhamnosus (ATCC 7469) and Lactobacillus plantarum (ATCC 8014). For a more thorough discussion of this product and these organisms go to:
Original Synbiotic Formula, Monograph
.

Another toxin in our diet, of increasing worldwide concern, that is adding to the de-evolutionary process, is mold mycotoxins, specifically the toxins aflatoxin and orchratoxin, which are extremely neurotoxic. They are not only neuro-toxic but are carcinogenic, mutagenic and immuno-suppressive agents. The Original strains were selected to meet this challenge: L. rhamnosus, which binds AFB1 in vivo, and reduces bio-absorption of the toxin from the gut; L. acidophilus and B. longum – neutralize AFB1 and AFM1 by binding mechanisms; and S. thermophilus – reduces content of ochratoxin A.

The Therapeutic Foods line was created as a response to the de-evolutionary process. It combines the power of 21st Century science along side a holistic/organic view of food. We believe technology paired with the systemic view of healthy life patterns can pull us out of the de-evolution predicament. Each formula is created with this in mind; each formula corrects diseased patterns and pathways, and helps our bodies to manifest full genomic potential.

Sincerely yours,

Seann Bardell

BioImmersion.com

Clinical Note: Therapeutic Foods, a New Platform in the Practice of Nutritional Medicine. We have created this half-hour webinar to assist health practitioner in successfully integrating these important formulas into their practices. Of the 15 different products in the Therapeutic Foods Line, 8 have probiotic organisms in them in differing combinations with differing organisms. Bringing in the most current thinking from the microbiome research we will help you understand and decide which formula/organism and therapeutic foods to use with a given patient.

The scheduled times for the webinars: there are two different times on each selected day to more easily accommodate our east coast and west coach doctors.

Webinar Schedule:

April 9th at 9:30am
(PST) and again at 12:30pm (PST)

April 10th at 9:30am
(PST) and 12:30pm (PST).

April 16th at 9:30am
(PST) and 12:30pm (PST).

April 17th at 9:30am
(PST) and 12:30pm (PST).

Each seminar is one-half hour, and to facilitate an easement in your note taking I have created the following one page document that I think you will find helpful. Click Here to Download our Synbiotic Formulas PDF

If you would like to join in with us on one of the webinars, simple email us at
sbardell@bioimmersion.com, letting us know which one and we will send you the link and phone number in order to join in.

Reef

The Last Quiz Answer: This is an impala with its symbiotic oxpeckers cleaning ticks off its body. Oxpeckers spend 30-35% of their foraging time upon impala hosts. The ears are the preferred region apparently due to high tick infestation of their ears.


Learn more about the synbiotic relationship between Impalas and Oxpeckers:

http://www3.interscience.wiley.com/journal/119211320/abstract