Dear Friends,

The BioImmersion Therapeutic Foods are built with advanced technology that maintains the wholeness of foods while utilizing the exact science of molecular concentration for therapeutic purposes.

Our new Coffea Arabica serves as a prime example. Using a newly developed proprietary drying technology we are able, for the first time, to offer the phytonutrient rich whole coffee fruit and extract (minus the bean) for worldwide consumption.

The whole coffee fruit provides the benefits of exceedingly high ORAC levels, coffee phenolic acids (the chlorogenic acid family, ferulic acid, quinic acid), trigonelline, proanthocyanins, condensed tannins, essential monosaccharides, polysaccharides, and fiber.

A single gram serving of the whole powder made from the fresh red fruit provides the same anti-free radical power as 33 grams of fresh blueberries! Of course blueberries have other ingredients that are essentials,but in terms of ORAC it is exceedingly high. The dehydrated whole fruit in ORAC Units/ gram of the coffee fruit is 800, mangosteen is 300, blueberry is 300, acai is 300, raspberry is 275, and cherry is 275.

When we sort foods according to their ORAC score, we are looking at their potential oxygen radical adsorbent capacity. But what we really want to know is their actual performance in the body, and for that we must use other objective markers.

In last weeks Forward Thinking I listed the preliminary clinical data on the effects of coffee fruit extract on biomarkers associated with the French Paradox. In summary, the results were:

• A reduction of oxidized LDL (oxLDL)
• An increase of PON-1
• A reduction of isoprostanes
• A reduction of blood free radical levels
• A reduction of nElastase gene expression

What is the significance of these markers?

Oxidized LDL (oxLDL)- Oxidized LDL are low density lipoproteins (LDL) that have been oxidized due to the effects of free radicals within the body. The oxidized lipoproteins accumulate on arterial walls, a contributing factor in the development of atherosclerosis. Reduction of blood levels of oxLDL is an important element of the French Paradox.

Paraoxonase 1 (PON1)- PON1 is a human blood enzyme associated with maintenance of healthy HDL levels and reduction of oxLDL cholesterol activity. Healthy HDL levels have been associated with a decreased risk for the development of cardiovascular diseases. Elevated oxLDL levels have been associated with an increased risk for the development of cardiovascular diseases. PON1 activation could be a potential strategy for heart health management. As PON1 levels increase oxLDL levels decrease and HDL levels increase.

Isoprostanes- Lipids are readily attacked by free radicals, resulting in the formation of a number of peroxidation products. Isoprostanes are one group of these compounds and they are derived by the free radical peroxidation of arachidonic acid. High blood levels of isoprostane is an indication of an excess of lipid oxidation occurring within the body.

Blood Free Radical Levels- Increased generation of ROS/RNS is implicated in the pathogenesis of a variety of human diseases, including neurodegenerative disease, atherosclerosis, cancer, and aging. Therefore, controlling blood levels of free radicals and minimizing oxidative stress improve cardiovascular health.

nElastase- Elastase is an enzyme that destroys a number of proteins, including elastin, an elastic substance that supports the structure of organs and tissue. Elevated levels of elastase contributes to cardiovascular condition by breaking down proteins and connective tissue. Elastase inhibition has been associated with improved skin elasticity, heart health, flexibility of arterial walls, management of COPD and Ulcerative Colitis.

Welcome to BioImmersion’s coffee growing country where green technology is used to promote sustainable agriculture that heals the environment. We believe in social equity and are committed to supporting socially responsible fair labor practices. As you know it is our belief that environmental protection and economic growth go hand-in-hand with good economic policies and advanced technologies to achieve a sustainable economy, environmental quality and social equity.

The new BioImmersion Coffea arabica contains 60 vegetarian capsules filled with 650mg of whole coffee fruit (minus the bean, and therefore the caffeine hit) and 100mg of the fruit extract (as used in the study). The polyphenol level is standardized at 40%, the ORAC is 1125 per gram, the caffeine level is less than 1%.

Sincerely yours,

Seann Bardell

BioImmersion.com

Clinical Note:

This week we are highlighting our Organic Chlorella. Chlorella is a powerful, complete whole food with tremendous potential, because of its growth rate and nutritional content, for feeding a malnourished and starving world—this has been the primary thrust for the robust research on Chlorella, around the world, over the last 50 years.

The greenest of all green plants, chlorella contains the most macronutrients—over 50% protein (the highest percent of protein of any food on earth), 12% lipids in the form of ALA and GLA, 23% carbohydrate, 0.3% fiber and 411 calories per 100 grams. It is a foundation food for all of life.

The Last Quiz Answer:

There are nine species of pelicans, and they can be divided into two groups; those with mostly white adult plumage, which nest on the ground (Australian, Dalmatian, Great White and American White Pelican) and those with gray or brown plumage, which nest in trees (Pink-backed, Spot-billed and Brown, plus the Peruvian Pelican which nests on sea rocks).

The Dalmatian is the largest of the pelicans, around 6 feet in length, 30 lbs in weight, and just over a 10 foot wing span. It is the worlds heaviest flying species.

The Brown Pelican is the only species of pelicans that dive into the water to catch their dinner, often diving from thirty feet.

This marvelous creature is a Great White Pelican.

This is very damaging and needless government regulations. Please pass this along to everyone you are willing to send this to. Re: Action Alert—Ask you legislator to oppose Senator Durbins Dietary Supplement Labeling Act of 2011 (S. 1310).

Dear Friends,

When you think of coffee, you are probably not thinking about fruits. But coffee starts with the bright red cherry like fruit (see the beautiful picture below). The seeds of the fruit are the coffee beans, which are roasted and then used to prepare the addicting coffee we love and cherish. The coffee plant has its origin in Ethiopia where it was discovered around 800 AD in the Kaffa region. In almost all languages, the name coffee refers to this region, but funny enough in Ethiopia the name is quite different as the Ethiopians call it Buna.

There are about 10 species of coffee. The 3 most commonly used are Coffea Arabica, Coffea canephora and Coffea liberica. Originating in Ethiopia and north of Kenya, the plant is now grown in the tropical band around the world—north of the Tropic of Capricorn, south of the Tropic of Cancer. Coffee requires a cooler tropical climate. In the tropics, it is usually grown at altitudes between 1300 and 1500 meters but sometimes higher.

The coffee fruit is round to oblong and ripens to a bright red. Each berry contains two seeds, which are what we call the coffee beans. The ripe fruit’s flesh (skin and pulp)is removed (usually by machine)and separated from the seeds (coffee beans), which are then fermented to remove the slimy layer still covering the beans. Then the beans are washed to remove fermentation residue and dried. The green seeds are then roasted before they are used to brew coffee. But what of the bright red pulpy fruit? What happens to it?

That is the question of the hour—the fruit contains extremely high levels of polyphenolic and essential sugar power. Our new product Coffea arabica offers exciting newly researched protective and healing benefits of the pure coffee fruit and coffee fruit extract.We always loved our cups of coffee, now we will learn to love the coffee fruit.

We will divide our discussion up into two parts: the polyphenols and the essential sugars. We will look at coffee fruit’s unique and powerful polyphenols this week and next, to be followed by a discussion on the benefits of the coffee fruit’s important and life sustaining essential sugars.

The French Paradox opens the door into the discussion of maintaining high levels of polyphenols in our diet. What’s the French Paradox? It refers to the fact that although the French consume three times as much saturated fat as Americans, one third less French people die from heart attacks and obesity than American people. The French eat a high fat diet and don’t get heart disease. In France, each French man, woman and child consumes 40 pounds a year of many different kids of cheese.

So what stops the clogging of the arteries? There are several proposed factors. Some medical researchers maintain that cheese is not a problem but drinking cow’s milk is. Americans drink lots of milk and the French don’t. It has to do with the difference in the relationship of calcium between milk and cheese. In cheese, because of fermentation caused by our good friends, the lactic acid bacteria, the calcium neutralizes the fat by combining with it, and causing it to be excreted from the body rather than being absorbed. According to certain researchers, milk promotes heart disease because the calcium will not combine with the fat and the fat goes into the blood stream.

The other major reason for the French Paradox is the French daily consumption of red wine, which is packed with the polyphenol subgroup proanthocyanidins (OPCs). Let’s review the scientific biomarkers associated with the French Paradox. These are:

• A reduction of oxidized LDL (oxLDL)
• An increase of PON-1
• A reduction of isoprostanes
• A reduction of blood free radical levels
• A reduction of nElastase gene expression

In a soon to-be-published double blinded study, 100mg BID of coffee fruit extract, standardized to 40% polyphenols, achieved the same health benefits goals as shown in the movement (increase and decrease) of the markers that is characteristic of the French Paradox.

The new BioImmersion Coffea arabica contains 60 vegetarian capsules filled with 650mg of whole coffee fruit (minus the bean, and therefore the caffeine hit) and 100mg of the fruit extract (as used in the study). The polyphenol level is standardized at 40%, the ORAC is 1125 per gram, the caffeine level is less than 1%.

Sincerely yours,

Seann Bardell
BioImmersion.com

Clinical Note:

This week we are highlighting the Cruciferous Sprout Complex. The Cruciferous Sprout Complex stimulates the body’s production of the powerful P2P enzymes. They are major enzyme players in the body’s Antioxidant Defense System. There are 24 of these Phase 2 Proteins. They are critically important to every cell’s defense against free radicals, toxins elimination, and cancer protection.

The Last Quiz Answer:
This marvelous creature comes from the tropical land of coffee—Central and South America. It’s a Giant Anteater. There are four different species of anteaters, some as small as a squirrel, and some like this one that can reach a length of seven feet and a weight of 140 pounds. Anteaters are generally solitary animals. Females have a single offspring once a year, which can sometimes be seen riding on its mother’s back.

They consume up to 30,000 ants and termites a day and are quite the horticulturalists. Rather than totally devour the whole termite or ant nest, they harvest only a portion of the insects at a particular site, so that they can return at a later point in time when the insect population has repopulated. Anteaters are not aggressive but they can be fierce. A cornered anteater will rear up on its hind legs, using its tail for balance, and lash out with dangerous claws that can be 4 inches long. They can fight off even a puma or jaguar. Don’t worry they won’t bite you—they have no teeth.

Here’s a little bonding with an anteater.

A new study by Harvard School of Public Health researchers finds a strong association between the consumption of red meat- particularly when the meat is processed- and an increased risk of Type 2 Diabetes.

Dear Friends,

The war of microbes and human health is fought on a battlefield of carbohydrates! As parts of our industry are demolishing “sugars” as a needed nutrient, a whole body of evidence by the world of glycobiology is teaching us otherwise: Sugars are important to our good health. The question is: what kinds of sugars do we need?

Good nutrition requires getting the requisites of fats, carbohyrates, proteins, vitamins, minerals, and phytonutrients into our bodies on a regular basis. But in that list of important nutrients to consume did you think to make sure you got your fucose (not fructose) today, or your mannose, or for that matter, any of the 9 essential monosaccharides? Bet you didn’t. I know I haven’t for most of my life, until recently, as I was working with our scientists on developing one of our new products, which contains 5 of the essential sugars. This product will be coming out in about four weeks, and I am very pleased to be able to introduce it to you in this week’s Forward Thinking.

Let’s review why the essential sugars are important. Vertebrates uniquely use the essential nine monosaccharides: mannose, xylose, fucose, galactose, glucose, N-acetylglucosamine, sialic acid, N-acetylgalactosamine, and glucouronic acid. They are called essential because they are critical in the formation of the glycans—glycans are the linear and branched polymers of these sugars that dangle off of cell membranes attached either to membrane bound proteins (glycoproteins) or membrane lipids (glycolipids).

The glycans can be extremely complex in structure and form the unique sugar coating for each cell type. All cells are literally sugar coated. Two weeks ago we discussed the Clusters of Differentiation of the immune system (which is basically another name for the glycome of immune cells), and the four human blood types—A, B, AB and O, which are distinguished by differing arrangements of four of the essential sugars—fucose, galactose, N-acetylglucosamine and N-acetylgalactosamine.

The study of glycans within the field Glycobiology is a very difficult subject matter. For example, when studying nucleic acids there are 4 nucleotides arranged in a linear manner: T-C-A-G-G-G-A-T-C-C-A-T-etc. or when studying proteins, there are 20 amino acid arranged in linear polypeptides: Ser-Pro-Leu-Cys-Lys-Gly-Thr-etc., arrangements that are relatively straight forward and can be sequenced and analyzed by sequencing machines. But, when you study glycans, there are 9 essentials sugars arranged in both linear and branched molecular structures. These structures not only become incredibly complex, but also are constantly changing on the cell surface depending on the cell’s metabolic state, or its state of health or disease. They are fluid, changeable, and difficult to study.

What is very clear from the mounting research on essential sugars, the glycans and the glycome (or glycocalyx), is that they are of major importance to the study of medicine. As pathogens try to invade, they have to get through the complex sugar coat. The war of microbes and human health is therefore fought on a battlefield of carbohydrates. The glycans are involved in immune reaction, in recognition of self, and of invaders. They are involved in adaptive immune responses as well as innate immune responses. They are involved in inflammatory responses. Glycan expression exists across a wide array of biological processes, including cell communication, host protection, transcription, differentiation, activation, apoptosis and structure.

Due to our modern fruit and vegetable deficient eating habits, and with heavy reliance on processed foods made with refined sugar, most of us do not get enough of the essential monosaccharides required for healthy cell communication and immune functioning. Additionally, many foods containing the less common monosaccharides are neglected in modern diets.

When eating foods rich in these sugars, the saccharides are absorbed into our cells and routed to the endoplasmic reticulum and the golgi bodies. The membrane bound organelles are basically an assembly line for the construction of complex glycans from these building blocks. The glycans are then attached to a protein or a lipid and delivered to cell membranes.

Glucose is the parent of all the essential sugars and can build them—if it has to. But it is best for our robust health and longevity that we obtain them from our diet. So, where do we get these critically important monosaccharides in our diet?

A very rich source of the saccharide building blocks for glycans are found in our new product: Coffea Arabica- Freeze-dried Fruit and Extract. That’s right—coffee fruit without the bean (where 99% of the caffeine is found).

Until recently, the whole fruit (minus the bean) of the coffee plant has not been commercially available due to its perishable nature. Thanks to technology and science, we have discovered a unique means of safely cultivating, harvesting and processing the coffee fruit. The fruit is loaded with exceptionally high concentrations of beneficial phenolic acids and other extraordinary nutrients like the coffee saccharides. The healthy attributes of whole coffee have been common knowledge to people living in coffee-growing regions since time began. But until now, these benefits could only be enjoyed by a few because coffee fruit was impossible to process and export. Next week we will more fully develop the powerful benefits to be derived from this wonderful coffee fruit.

Sincerely yours,

Seann Bardell

BioImmersion.com

Clinical Note:

This week we are highlighting the No. 7 Systemic Booster. The No. 7 Systemic Booster components work together as a daily Therapeutic Food to strengthen the function of the immune system, gastrointestinal system, osteo-skeletal system, cardiovascular system, endocrine system, uro-genital system, respiratory system and the neurological system. It is our most complete formula.

The Last Quiz Answer:

One Happy Humpback Whale! This is an amazing video shot in the Baja by the family that saved this young whale who had been caught up in a gill-netters net and was on the verge of drowning. They save her life and she in return put on quite a show for them. Her way of saying thank you? They named her Valentina. Would you have gotten in the water to save this magnificent creature?

Researchers can now watch molecules move in living cells, literally millisecond by millisecond, thanks to a new microscope developed by scientists at the European Molecular Biology Laboratory in Heidelberg, Germany.

Dear Friends,

When one looks at supplements or food labels under the Supplemental Facts, the carbohydrate listings can be confusing. In this newsletter I will go over how to understand the content regarding carbohydrates. In the process, I will also introduce to you and spark your interest for two of our new products coming out later this month.

Last week we discussed the essential sugars, making the point that they are all monosaccharides. There are nine of them: glucose, galactose, mannose, fucose, xylose, sialic acid, N-acetylglucosamine, N-acetylgalactosamine, and glucouronic acid. Fructose is a monosaccharide but it is not considered an essential sugar.

When you look at a product label, for example, one of our new products that will be coming out later this month—Energy Sustain Complex, you will notice under the Supplemental Facts several listing for the Carbohydrates with three categories: Sugars, Fibers, and Other Carbohydrates. In the case of Energy Sustain, per 30g daily serving, one gets:

• Sugars 0.31g
• Other Carbohydrates 13.10g
• Dietary Fiber 7.66g

The Sugars category refers to monosaccharides and as you can see the quantity is relatively small.

The Other Carbohydrates division is for complex digestible carbohydrates—the disaccharides, oligosaccharides (3 to 10 single sugar units) and polysaccharides (starches, containing hundreds to thousands of glucose molecules).

Digestible complex carbohydrates, such as starch, fall into two categories—amylose and amylopectin, each containing many glucose molecules linked by alpha bonds. The difference between the two is in the arrangement of the glucose units. Amylose is a linear or straight chain of molecules while amylopectin is highly branched. Our digestive enzymes only act at the ends of the glucose chains, the more numerous the branches in a starch, the more sites (ends) available for enzymatic action. This explains why alpha bonds in amylopectin are digested more rapidly than those in amylose. In the body, this causes blood glucose levels to increase more quickly after digesting amylopectin rather than the slower paced amylose.

The Dietary Fiber grouping contains the soluble and insoluble fibers that our bodies can’t digest as the glucose molecules are linked together by beta bonds. The insoluble fiber absorbs water, helps to remove toxins, and provides bulk—stimulating peristalsis and decreasing intestinal transit time, thus reducing risks of constipation, diverticular disease, and cancer. The soluble fiber provides food for the good bugs, the lactic acid bacteria that ferment and convert soluble fibers into many important metabolites that our bodies need for optimal health. Soluble fibers have been shown to lower blood cholesterol levels and blood glucose levels, thereby reducing risks of cardiovascular disease and diabetes. They also have been shown to protect against leaky gut syndrome and to reduce the risk of colon cancers through their production of the metabolic byproduct—butyric acid.

The Energy Sustain Complex is made up of organic amaranth, organic quinoa, organic buckwheat, organic chia—all seeds, and organic millet, the one true grain. The complex also contains red apple extract. The glycemic index value for the Energy Sustain is 50, which puts it in the category of a low glycemic index (GI) food. More importantly, its glycemic load (GL) is 6.7, and as you know, any food below 10 is classified as a low GL food. What’s more, the longer you let the Energy Sustain sit in water, the more viscous it becomes because of its soluble fibers. Increased viscosity lowers the GL even more.

With the Energy Sustain Complex you have a couple of choices. If you feel the need for a more rapid hit of sugar energy, then drink it immediately upon mixing. On the other hand, if you feel you want a more sustained energy released into your body slowly, let it become more viscous before drinking.

But the Energy Sustain Complex provides much more than just energy because it is food—a whole food. As we have seen above, it provides 7.66g of fiber per serving, that’s one-quarter of the recommended daily intake. It provides a rich supply of amino acid with 4.59g of complete protein per serving. It provides many vitamins and minerals, and essential fatty acids. And, it provides red apple extract. We will further discuss our new global indigenous seeds, grain, and extract in future Forward Thinking newsletters.

Next week, we will get back into Glycobiology and illuminate some of the medical research on glycans and the individual essential sugars that makes them up. This is very relevant as another of our new products is coming out this month, a product that provides powerful amounts of these crucial monosaccharides necessary for the building of the glycans. See you Next Week!

Sincerely yours,

Seann Bardell

BioImmersion.com

Clinical Note:

This week we are highlighting the Cranberry Pomegranate Synbiotic Formula. With organic cranberry and pomegranate extracts, powerful Bulgarian probiotic organisms, supernatant, D-mannose and inulin,this product is proving to be a wonderful support for achieving and maintaining gastro-intestinal and urogenital health.

The Last Quiz Answer:

Hyena Queen follows a true story of high drama in the Charleston clan, a family of spotted hyenas living on South Africa’s Mala Mala game park. This story is possible thanks to eight years of effort by filmmaker Kim Wolhuter. In this short clip you see Kim chronicling his evolving relationship with the clans Queen Nikita and her two cubs. Hyena Queen was nominated for the coveted Panda Award at the 2008 Wildscreen Film Festival.

Recent studies show that automakers could reach the 54.5 mpg threshold with just tweaks to existing car design. And, while these incremental improvements are a step in the right direction toward mitigating the economic and environmental impacts of oil use, RMI experts suggest that the time is right for automakers to seize an opportunity to reestablish themselves as global leaders in innovation, manufacturing and performance. (Read More)