BioImmersion -- Therapeutic Food Supplements

Welcome Friends,

We invite you to contribute articles & research, thoughts & poems, analysis & solutions; to publish and converse with old and new friends, fellow world citizens, dedicated to bring peace into the chaos of the globe we call home. We have seeded the blog with some articles and thoughts to get the conversation going. The categories on the right will expand as our entries and foci evolve. Lets start writing and publishing!

Contact us about publishing to the blog: publish@bioimmersion.com.

  • Activating Probiotics

    Dear Friends,

    How do ORNs "activate" probiotics and modulate the immune system of animals and humans?

    The LactORNs replace a nutritional ingredient lost in the Western diet due to all the processing of foods that we eat. Our bodies have evolved with ORNs from bacteria as an important component of our diet.  ORNs released in our mouth activate probiotics to grow and stimulates and balances our immune systems.  This has been shown in the immune systems of all animals tested—from shrimp to fish, mice, rats, pigs, cows, and humans (Marshall, 2007).

    As we have learned last week, our diets lack in sufficient amounts of ORNs because we do not eat fermented foods. Furthermore, most of the yogurts and fermented vegetables available to us lack ORNs. This means that we are seriously deficient in this important nutritional element that helps our bodies fight infection.

    All bacteria contain ORNs. Marshall (2007) has discovered that ORNs are small fragments of RNA weighing <10,000 Daltons. They are released immediately when bacteria are transferred from acidic culture media into saliva or pH neutral buffer.

    Mice fed free <10kDaONRs released by L. casei, prior to a lethal injection of lipopolysaccharide (LPS) are protected from toxic shock death.

    Exposure to <10kDaORNs stimulates innate and adaptive immune responses in hosts as diverse phylogenetically as teleosts and mammals.

    In-vivo studies with shrimp and cattle show protection against infections when fed with <10kDaORNs released by Generally Recognized As Safe (GRAS) bacteria and yeasts.

    The co-evolutionary release and immune modulation by exRNAs (external RNAs) appears to be well-conserved among the microbial and mammalian kingdoms.

    Diets of pasteurized and processed foods do not provide sufficient amounts of GRAS organisms to release the exRNAs that modulate an immune response, nor do typical probiotics or commercial yogurts.

    Since the discovery that eukaryotic cells release exRNAs that regulate expression of their genes as well as those of nearby cells, we felt it reasonable that a similar phenomenon might exist in bacteria and that the <10kDaORNs were exRNAs or transcriptional factors that control expression of their growth cycle genes.

    Through co-evolution, mammalian immune cells adapted a response to them.  In-vitro studies in humans as well as in-vivo studies in mice, shrimp, fish and cattle fed <10kDaORNs released by GRAS organisms significantly increased their protection against infection and the lethality of septic shock.

    The L. casei doesn't have to be cultureable but remains viable but if it is and enters a human mouth with a neutral pH of 7 then the bacteria accomplishes two things:  it will release its ORNs which stimulates the oral immune system to respond, and two, the release of ORNs causes an immediate cell division by those bacteria for whom the release of ORNs has occurred when they are returned to an environment rich in nutrients.

    If all the bacteria have not released their ORNs in the mouth, those that didn't will release them when they again reach an area with an alkaline pH such as the small intestines.  They start to divide and multiply with no lag time.  If the pH of the mouth is more acidic than 5, only 1/3 of ORNs will be released.  One can add the LactORNs to a baking soda drink (the formula can be found on the back of a box of Arm and Hammer baking soda and gargle to insure that all LactORNs are released.

    There is no toxicity to the ORNs.  They restore the immune system without causing chronic inflammation.  The cytokines released are IL-1, IL-6, IL-4 and TNF alpha.  To IL-1 and 6 control inflammation and IL-4 activates B-cells and antibody production.  IL-6 seems to protect the body from too much inflammation.  Overall low level of inflammation are incited to prepare the immune system for a more effective prevention of infection from bacteria and virus.

    Dosage:  Individuals taking prescription drugs should inform their doctors before taking LActORNS.  A restored immune systme may be more sensitive  to  the drugs and the prescription might need to be changed.   For example statins may be need to be lowered or eliminated and HBP medication may need to be reduced as well as blood thinners.

    Marshall W. 2007. Oligoribonucleotides alert the immune system of animals to the imminence of microbial infections. US patent 7,189,834 B2

    LactORNs 3

    Sincerely yours,

    Seann Bardell
    BioImmersion.com

    Clinical Note:

    Our LactORN is the only probiotic supplement in the market that specifically grows the ORNs. Take one level teaspoon two to five times a week, depending on the weakness of the immune system. Continue to take the one of the probiotics mixes for a diverse microbial support of the GI, such as Original, No 7, or Supernatant. Add fibers such as the Beta Glucan or Energy Sustain for even a greater nutritional support.

    LactORN Bottle
    ORN Supplemental Facts 2

     

     

    This amazing little creature is a Fennec Fox who lives, as a nocturnal animal, in “of all places” the Sahara Desert.

    The Last Quiz Answer:

    This stocky, robust water loving antelope is a waterbuck. Their calves begin to eat grass when they are very young, yet they are nursed for as long as 6 to 8 months. Waterbucks don't reach adult weight until about 3.5 years.

    They are a large antelope, can weigh as much as 660 lbs, at the shoulders be 4.5 feet tall, and with a body length of 7.9 ft.  Herds form up to 30 individuals.  They are known to live up to 18 years.  Here is a short video of a beauty

     

     

     

    Green Facts

    Here's more proof as to diet's influence over our maintaining a healthy microbiome throughout our life. Just look at the elderly.

    Claesson et al. (2012) state that, the gut microbiota composition correlates with diet and health in the elderly.  Their microbiota composition significantly correlates with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water.  The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers.  Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon aging.

    Claesson et al. (2012). Gut microbiota composition correlates with diet and health in the elderly. Nature;488:178-184

  • ORNs- a missing ingredient in our diet

    Dear Friends,

    Our new LactORN probiotic supplement supports the restoration of an immune system compromised by stress, thereby increasing the ability of the body to fight infections.

    As we have learned last week, our diets lack sufficient amounts of ORNs because we do not eat fermented foods.  Furthermore, most of the yogurts and fermented vegetables available to us lack ORNs. This means that we seriously lack this important nutritional element that helps our bodies fight infection.

    Marshall (2007) findings indicate that with ORNs, we restore an immune system compromised by stress—our abilities to fight infections are enhanced.

    The field of psychoneuroimmunology has provided new insights to help understand the pathophysiological processes that are linked to the immune system.  Work in this field has established that psychological stress disrupts the functional interaction between the nervous and immune systems.

    Stress-induced immune dysregulation has been shown to be significant enough to result in health consequences, including reducing the immune response to vaccines, slowing wound healing, reactivating latent herpes-viruses, and enhancing the risk for more severe infectious disease.

    Kanfer et al, 2011 observed high Cortisols to DHEAS ratios in bereaved older adults.  High Cortisol to DHEAS levels is a stress marker.  Neutrophil superoxide production was significantly reduced among the bereaved when challenged with E. coli.

    The stress of bereavement exaggerates the age-related decline in HPA axis and combines with immune aging to further suppress immune function, which may help to explain increased risk of infection in bereaved older adults.

    Godbout and Glaser (2006) found that the stress of hostile marital relationship interaction showed a 60% reduction in wound healing repair, which was associated with a decrease in proinflammatory Cytokine IL-1, IL-6 and TNF-alpha at the wound site.

    Our immune system's job is to protect us from pathogenic microbes and toxins.  A weakened immune system leaves our bodies vulnerable to these pathogens and resulting infections.

    References:

    • Kanfer et al. (2011). Neutrophil function and cortisol:DHEA ratio in bereaved old adults. Brain, Behavior and Immunity. University of Birmingham, UK.
    • Godbout, J.P., & Glaser, R. (2006). Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer. J Neuroimmune Pharm;1:421-427.
    • Marshall, B

     

    LactORNs 3

    Sincerely yours,

    Seann Bardell
    BioImmersion.com

    Clinical Note:

    Our LactORN is the only probiotic supplement in the market that specifically grows the ORNs. Take one level teaspoon two to five times a week, depending on the weakness of the immune system. Continue to take the one of the probiotics mixes for a diverse microbial support of the GI, such as Original, No 7, or Supernatant. Add fibers such as the Beta Glucan or Energy Sustain for even a greater nutritional support.

    LactORN Bottle
    ORN Supplemental Facts 2

    This amazing little creature is a Fennec Fox who lives, as a nocturnal animal, in “of all places” the Sahara Desert.

    The Last Quiz Answer:

    This little beauty is a Africans Spring buck.  There are more than 70 antelope species roaming around on the African continent.  They range from very small, like the suni which is only 12 to 16 inchers tall, to large like the eland which is about 8 to 11 feet tall.  Think about that for a second.  That is tall!

    Africa is known as the land of the antilopes.  To address the diversity, scientists have grouped them into 7 groups:  the duikers, a group of small to medium sized antelopes;  the dwarf antelopes; the gazelles- they are medium sized;  the horse antelopes- these are large and very strong and muscular; the antelopes that have high shoulders, long and thin legs and long bushy tails and finally a group that has spiraled horns.  This curious friend is a Spring Buck.

     

     

    Green Facts

    Here's more proof as to diet's influence over our maintaining a healthy microbiome throughout our life. Just look at the elderly.

    Claesson et al. (2012) state that, the gut microbiota composition correlates with diet and health in the elderly.  Their microbiota composition significantly correlates with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water.  The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers.  Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon aging.

    Claesson et al. (2012). Gut microbiota composition correlates with diet and health in the elderly. Nature;488:178-184

  • What is the missing ingredient in our probiotics?

    Dear Friends,

    Over the last two weeks we have been talking about our new product—LactORN: Lactobacillus ORNs—characterizing it two weeks ago as The Next Generation Probiotic and last week as The Most Important Nutrient Missing in our Diet.

    This week we will provide further illumination as to what ORNs are and how they benefit and protect our health.

    What are ORNs?

    ORNs (oligoribonucleotides) are the products of the destruction of ribosomal RNA, which occurs naturally with the slowing of bacterial growth. As exponential growth
    slows, ribosomal RNA is hydrolyzed, creating very acidic oligoribonucleotides, which accumulate in the cytoplasm.
    If the media outside the bacterial maintains the same acid pH then said bacteria stop growing, hanging on to their ORNs.

    Oligoribonucleotides are RNA fragments ranging from 1 to 30 nucleotides, which are resistant to further hydrolysis by RNase.  They reside in the cytoplasm of all bacterial cells. When a bacteria enters a new the cavity of the human mouth, (ideally with a pH betweem 6 to 8), the bacteria immediately releases its ORNs.

    This release of ORNs does not kill or injure the bacteria from which they were released, but rather assists them in establishing a colony in a new environment by increasing their rate of mutation and their growth.

    How do they work?

    The oligomeric fraction having a molecular weight of less than 10,000 Daltons (<10kDa) and, in particular, between 500 and 3,000 DA are readily absorbed, are non-toxic and both activate and modulate the immune system.

    Encountering neutral pH , such as the mouth will induce the release of these ORNs, which will serve to alert the host immune system in the mouth.  Embedded sentinel cells in the oral pharyngeal tissue, such as the macrophages, are activated to release cytokines at levels deemed helpful to combating infections and are also down-modulated to prevent over-activation. The circulating monocytes and macrophages, and B- and T-cells of the adaptive immune system are upregulated as well.

    Approximately twenthy different interleukins can be released modifying, amplifying, restricting and dampening messages as the system is stimulated.  For example by down-regulating the number of CD-14 and CD-16 receptors on the surface of the macrophage, the oligomers released by the bacteria help to ensure that the macrophage does not become over-activated by interleukins.

    The benefits provided by ORNs.

    The ORN<10kDa are a rich new source of natural, normally-occurring, co-evolutionarily evolved immune modulators that can be safely used to protect animals and humans from infections and the over-stimulation of their immune system.  In addition, this faction contains compounds that can be used to adjust the expression of individual surface receptors on macrophages to re-center a dysfunctional immune system.

    Marshall, W. (2010). Methods for the accumulation and retention of immune-enhancing, bacterial-derived ribonucleotides (ORN) in bacteria.  US patent No. US 7678557 B2.

    Sanders, ME. (2003). Probiotics: Considerations for Human Health. Nutrition Reviews; 61(3):91-99.

    Shanahan, F. (2004). Probiotics and the Immune Response: How Much Can We Expect? Journal of Gastroenterology and Nutrition; 39(3):748-749.

    LactORNs 3

    Sincerely yours,
    Seann Bardell
    BioImmersion.com

    Clinical Note:

    LactORN contains the probiotic Lactobacillus casei grown in a way to retain its natural oligoribonucleotides.  Plus it contains the prebiotic inulin derived from organic chicory root. Take one tsp 2 or 3 times a week for immune support.

    LactORN Bottle
    ORN Supplemental Facts 2

    This amazing little creature is a Fennec Fox who lives, as a nocturnal animal, in “of all places” the Sahara Desert.

    The Last Quiz Answer:

    This turtle is a sea turtle.  Unlike other turtles, sea turtles cannot retract their legs and head into their shells.  There are seven species in the world.  They can live 80 years.

    Green Facts

    Industrial Agriculture, Agroecology, and Climate Change

    Today it is becoming more and more evident that the major problems of our time — energy, the environment, climate change, food security, financial security — cannot be understood in isolation.  They are systemic problems, which means that they are all interconnected and interdepenent, and they require corresponding systemic solutions.

    If we changed from our chemical, large-scale industrial agriculture to organic, community-oriented, sustainable farming, this would contribute signifcantly to solving three of our biggest problems: our energy problem, our chronic disease problem, and our climate change problem.

    (A formative article by Fritjof Capra (2015), cofounder of The Center for Ecoliteracy, and author of such seminal books as: The Systems View of Life and The Tao of Physics.)

  • The Next Generation Probiotic- Part II

    Dear Friends,

    We lack one of  the most important nutrients in our diet.

    Certain good bacteria, grown specifically to preserve its Oligoribonucleotides (ORNs),  supply a missing important nutrient that stimulates our very immune system to be more alert and ready to protect us from possible pathogens; and accomplishing this without over-stimulating the immune system.  What are these nutrient elements, ORNs, and why are they missing in our diets?

    Oligoribonucleotides (ORNs) are fragments of genetic material, the RNA pieces that reside within the cytoplasm of all bacteria.  When we eat unprocessed, fermented foods (e.g., raw milk, vegetables etc.) in its natural state, bacteria and their ORNs comes along with the food. A cup of fermented raw milk may  contain as much as 30 AUs of lactic acid bacterial ORNs. Since we do not ferment raw foods, and typically wash away the ORNs in the production of probiotics, this missing ingredient has been costly to our health. We need ORNs as a natural part of our nutritional makeup.

    Arbitrary Units (AUs) are a unit of measurement to quanity ORNs.  I described in last weeks newsletter—The Next Generation Probiotic— how ORNs set off a chain reaction of beneficial events, initiated through our immune cells, first in our mouth, and then small intestines, that upregulate our immune system.  30 AUs of ORNs is sufficient to upregulate the human immune system through the oral cavity.  Our new LactORN provides 30 AUs of ORNs per one level teaspoon.

    LactORNs 3

    Sincerely yours,

    Seann Bardell

    BioImmersion.com

    Clinical Note:

    LactORN contains the probiotic Lactobacillus casei grown in a way to retain its natural oligoribonucleotides.  Plus it contains the prebiotic inulin derived from organic chicory root. Take one tsp 2 or 3 times a week for immune support.

    LactORN Bottle
    ORN Supplemental Facts 2

    This amazing little creature is a Fennec Fox who lives, as a nocturnal animal, in “of all places” the Sahara Desert.

    The Last Quiz Answer:

    Is this a two toed or three toed sloth?  There are two species of sloths: two-toed and three-toed.  Most are about the size of a small dog.  They can live up to 30 years, and live most all of those years up in the trees of the jungles of Central and South America.  They feed on fruit, leaves, buds, and young twigs.  Because of their slow metabolism they need to eat very little.  Some sloths stay in the same tree for years. This beauty is a two-toed sloth. 

    Green Facts

    What better way to connect with the heart of nature for us city dwellers than to connect with a video of Jane Goodall's work with Chimpanzees in Tanzania.
    Explore Gombo National Park with Goodall's beautiful narration.

  • The Next Generation Probiotic

    Dear Friends,

    The new product is here: LactORNs—the next generation in probiotics.

    New research indicates friendly bacteria of unprocessed fermented foods retain their oligoribonucleotides (ORNs) which are then released when eaten, because of the saliva's pH (Marshall, 2007). A chain of reactions then occures:

    Immune cells, imbedded in oral tissues, respond to these ORNs by releasing stimulating cytokines that restore the powers of the immune network.

    An alerted immune network successfully defends the host against chemical toxins, viruses and bacteria without side effects.

    Either before or during stress conditions a daily dose of ORNs will maintain or restore the animal and human’s immune system compromised by stress.

    At this point, the typical probiotics manufacturing process does not retain the bacterial ORNs, they are discarded with the supernatant. Most of you are familiar with our supernatant products, and understand the protective value that our Bulgarian scientists placed upon retaining the supernatant metabolites.

    In this new generation product, our focus is on the ORNs.

    You will notice a new unit of measurement on the label:  The right dose of ORNs is determined not by the animal’s body weight but rather by the number of immune cells in its mouth.  Therefore, Colony Forming Units (CFUs) are not used to determine the dose of ORNs.  The dose is based on the number of Arbitrary Units (AU) of ORNs released in the mouth. Research has determined that the optimal amount of AUs is different for each species of animal one is feediing.  For example the AUs for cattle is 10, for pigs is 2, shrimp even have their own unique AU as do laboratory mice and rats.  For humans the AU is 30. (Marshall, 2007).

    The development of ORNs starts with growing a selected strain of L. casei in a media that supports the retention of releasable ORNs.

    When the ORN concentration is maximum, the culture is freeze-dried in a manner preserving the ORNs of the Lactobacillus casei.

    The LactORN is a healthy addition to your existing probiotic supplementation. Think of it as your immune boosting tool. Across animal species, the LactORN has been shown to support immunes system competencies to prevent infections caused by viruses and bacteria. It also helps the body to protect itself from toxins (Marshall, 2007).

    Marshall W. 2007. Oligoribonucleotides alert the immune system of animals to the imminence of microbial infections. US patent 7,189,834 B2

    Sincerely yours,

    Seann Bardell
    BioImmersion.com

    Clinical Note:

    LactORN contains the probiotic Lactobacillus casei grown in a way to retain its natural oligoribonucleotides.  Plus it contains the prebiotic inulin derived from organic chicory root. Take one tsp 2 or 3 times a week for immune support.

    LactORN Bottle
    ORN Supplemental Facts 2

    This amazing little creature is a Fennec Fox who lives, as a nocturnal animal, in “of all places” the Sahara Desert.

    The Last Quiz Answer:

    There are 216 species of owls.  These two beauties are barred owls.  They are also know as hoot owls.  It is highly vocal and can be heard calling during the day and night.

    Their diet is diverse as they prey upon frogs, birds, rats, bats, mice, squirrels, snakes and insects. The barred is found through out most of North America, and a large part of the southern Provinces of Canada, living in deep, moist forests and woodlands.

     

    Green Facts

    Uprooting the Leading Causes of Death

    Death in America is largely a food borne illness, so says Dr. Greger, who offers practical advice on how best to feed ourselves and our families.

  • Diet shapes the gut microbiome

    Dear Friends,

    Reserach demonstrates that diversity within our GI tract microbiome has been greatly reduced. How does that effect our children's health?

    De Filippo et al. (2010) compared the fecal microbiota of European children to that of children from a rural African community.  The diets of the two groups differed greatly.

    The researchers enrolled 15 healthy children living in a rural village in Burkina Faso, Africa, and 15 healthy children living in an urban area of Florence, Italy.  All children were between the ages of 1-6 years.

    The diet of the African kids was predominantly vegetarian: low in fat and animal protein and rich in starch, fiber, and plant polysaccharides.  All food resource were completely produced locally, cultivated and harvested nearby their village.  Their diet consisted mainly of cereals (millet grain and sorghum), legumes (black-eyed peas), and vegetables.  Whereas the diet of the European kids was the typical western diet high in animal protein, sugar, starch, and fat. It was also low in fiber (from vegetables, legumes, whole grains).

    The gut microbiomes of the children differed greatly.  The African children had much greater microbial richness and diversity.  The researchers posited that exposure to the large variety of enviromental microbes associated with a high-fiber diet could increase the potentially beneficial bacterial genomes, enriching the microbiome; and that reduction in microbial richness is possibly one of the undesirable effects of globalization and of eating generic, processed (protein, fat, carbs), uncontaminated (with healthy bacteria) foods.

    De Fillippo et al. (2010). Impact of diets in shaping gut microbiota revealed by a comparative study in children form Europe and rural Africa. Proc Natl Acad Sci U S A, 107(33), 14691-14696.

    Sincerely yours,

    Seann Bardell
    BioImmersion.com

    Clinical Note:

    While certain bacterial families have developed resistance to antibiotics and have increased in our gut, other beneficial bacterial families decreased. This is of great medical concern.

    The Supernatant Synbiotic Formula was developed to support the gut, helping to protect it from nosocomal infections. Nococomal infections are those illnesses that one can get while staying in a health care facility from drug resistant bacteria, such a C. difficile.

    We put our Bulgarian scientists to the task of selecting strains of lactic acid bacteria that demonstrate the best inhibitory effect against Colostridial population.  It took them almost one year of work.  The results was the Supernatant Synbiotic Formula supplying a broad spectrum of powerful and safe probiotic organisms.  We have had wonderful feedback regarding this products efficacy.  This amazing little creature is a Fennec Fox who lives, as a nocturnal animal, in “of all places” the Sahara Desert.

    The Last Quiz Answer:

    The Koala is the only mammal which can survive on a diet of eucalyptus leaves.  Eucalyptus leaves are very fibrous and low in nutrition, and are extremely poisonous.

    Koalas have evolved a range adaptation to survive such a diet.  One is the microbial fermentation of the partially digested eucalyptus leaves.  In Barker et al (2013) study researchers found a highly complex and diverse ecosystem with considerable variation at the genus level.  The samples were dominated by sequences from the Bacteroidetes and Firmicutes phyla. (Barker et al. 2013. Investigation of the Koala hindgut microbiome via 16 S pyrosequencing. Vet Microbio, 167(3-4), 554-64.

    Green Facts

    The importance of diversity of species in all life forms as to their survivability shows up in many living examples.  In the latest, May 2015 Science American with the cover story, The Rise of the Tyrannosaurus, author American Paleontologist Stephen Brusatte states that this class of animals were extremely successful because of their great diversity of species.  Here's his inspiring lecture: Meet the new Tyrannosaurs.

  • Take ownership of your microbiome.

    Dear Friends,

    The microbiome is comprised of approximately 100 trillion mostly bacterial cells. It has been characterized as an extra organ, bestowing us with 100 times more gene power, than our own human cells can give.  In fact, Homo sapiens are being thought of, by some, as super organisms, made up of human cells and microbial populations that have co-evolved with us.

    This essential organ, the microbiome, provides the host with enhanced metabolic capabilities, protection against pathogens, education of the immune system and modulation of gastrointestinal development (De Filippos 2010).

    Together, the host and microbiome have been termed a ‘supra-organism’ whose combined activities represent both a shared target for natural selection and a driver of adaptive responses (Schnorr 2014).

    Although we are excited about our increased understanding of the GI tract microbiome, most of our knowledge emanates from research conducted on populations within the industrialized world.  What about traditional rural horticultural populations, living off the land with only some dietary influences from highly processed foods?  And how about the "hunter-gatherer" populations, the few that are left in the world: what constitutes their microbiome makeup and how does that reflect on their health?

    I have chosen three very interesting research papers that shed important life on the question of what makes up a healthy microbiome. The key words for healthy bodies are diversity in the diet, which is made up of mostly seasonal vegetables, fruits, legume, roots, but very little animal protein. See my article on food diversity.

    Obregon-Tito et al. (2015). Subsistence strategies in traditional societies distinguish gut microbiomes. Nat Commun 6, 6505. Doi: 10. 1038/ncomms7505.

    Schnorr et al. (2014). Gut microbiome of the Hadza hunter-gatherers. Nat Commun, 5, 3654. doi: 10. 1038/ncomms4654.

    De Fillippo et al. (2010). Impact of diets in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A, 107(33), 14691-14696.

    Sincerely yours,

    Seann Bardell
    BioImmersion.com

    Clinical Note:

    BioImmersion's Original Synbiotic Formula and the Supernatant Synbiotic Formula  provide good choices for supporting diversity in the microbiome.  Both formulas supply human derived symbiotic bacteria that have co-evolved with us and provide strong support for our healthy gastrointestinal functioning.

    I am amazed by the things I find out from your work with these formulas.  Just yesterday a doctor told me that the Supernatant Synbiotic Formula works to kill L-form bacteria.  She was very excited about this.  I am going to call her back and ask her for more of the details, which I will share with you.

    This amazing little creature is a Fennec Fox who lives, as a nocturnal animal, in “of all places” the Sahara Desert.

    The Last Quiz Answer:

    Meet Ray's Storm, a much beloved retired race horse who now lives as a family member with our dear friends in Alaska.  As Maureen say, "He's a hoot!"  He even has his own Facebook page.

    Did you know that many racehorses end up at slaughter auctions within a week of their last race, despite the fact that many tracks across the country have policies opposing this practice. (From Stud to Slaughter, 2013)

     

    Green Facts

    Learn How This Family Grows 6,000 Lbs of Food on just 1/10th Acre.

    Their website now get 6,000,000 hits a month from people all over the world interested in their amazing urban farm.  Heaven on earth we can create!

  • Probiotics for IBS, Anxiety and Depression?

    Dear Friends,

    Can chronic stress be a causative factor that brings on IBS? And, at the same time, does IBS cause anxiety and depression?

    Can certain probiotic dosing help ameliorate both conditions?

    Three important questions that Ait-Belgnaoui et al. (2014) asked in their research, "Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice."

    The researchers make a strong claim that their study demonstrates a connection between certain probiotics supplementation and the reduction of markers of stress, anxiety, and IBS. Stress affects the gut, and the gut affects the brain, and vice versa: it is bi-directional.

    Their claim is that Lactobacillus helveticus and Bifidobacterium longum given orally can help ameliorate chronic stress-induced abnormal brain plasticity, reduction in neurogenes, and increase in stress hormone.

    Their findings highlight the important role of bacteria in the bi-directional communication of the gut-brain axis and suggest that probiotic treament may prove to be a useful therapeutic alternative in stress-related disorders such as anxiety and depression.

    Ait-Belgnaoui et al. (2014). Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice. Neurogastroenterol Motil, 26, 510-520.

    Sincerely yours,

    Seann Bardell
    BioImmersion.com

    Clinical Note:

    BioImmersion's Original Synbiotic Formula and the Supernatant Synbiotic Formula  provide good choices for options in supporting of this most important gut-brain axis.

     

    This amazing little creature is a Fennec Fox who lives, as a nocturnal animal, in “of all places” the Sahara Desert.

    The Last Quiz Answer:

    This is the wild ass (Equus africanus).  It is believed to be the ancestor of the domestic donkey.  They live in the desert area of the Horn of Africa (Ethiopia, Eritrea, Somalia).  They can run almost as fast as a horse (around 45mph). They are a hardy animal and well adapted to desert life. They can sustain water loss of up to 30% of their body weight, and can drink enough water in two to five minutes to restore fluid loss.  About 570 exist in the wild.  For endangered species in our world see:

    EDGE: Evolutionarily Distinct & Globally Endangered

     

     

    Green Facts

    Allow me to blow your mind.  Who do you think would win in this fight?

                              Killer Whale vs. Great White

    National Geographic captures the video and the story.

  • L. plantarum, a very good friend!

    Dear Friends,

    We have chosen Lactobacillus plantarum in our Original and Beta Glucan formulas for research continues to show its many beneficial effects in both animal models and human studies.

    Recent studies have further supported the potential of L. plantarum in treating intestinal disorders (Guzman, 2013).

    IBS and Regularity:  A small, 40 patient randomized, double-blind clinical trial showed that L. plantarum resolved abdominal pain in all IBS patients compared to the control group and provided significant bowel movement regularity to constipated patients (Niedzielin, 2001).

    A recent, large scale follow-up clinical trial was performed using similar parameters and metrics and demonstrated beneficial effects relative to IBS (Ducrotte, 2012).

    Infection of E. Coli:  Notably Lactobacillus plantarum has been suggested to release factors that significantly inhibit pathogenic bacterial adhesion to the mucosa, inhibiting such organisms as E. coli which can cause E. coli-induced increase in barrier permeability (Mageli, 2002).

    Guzman et al. (2013). Diet, Microbiome, and the Intestinal Epithelium: An Essential Triuvirate? BioMed Research International, 425146 (Published online).

    Niedzielin et al. (2001). A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299v in patients with irritable bowel syndrome. European Journal of Gastroenterology and Hepatology, 13(10), 1143-1147.

    Ducrotte et al. (2012). Clinical trail:  Lactobacillus plantarum 299v (DSM, 9843) improves symptoms of irritable bowel syndrome. World Journal of Gastroenterology, 18(30), 4012-4018.

    Mangell et al. (2002). Lactobacillus plantarum 299 v inhibits Escherichia coli-induced intestinal permeability. Digestive Diseases and Sciences. 47(3), 511-516.

    Lactobacillus plantarum is a good friend.  It is not only will function as a trusted warrior in your digestive tract, but it is also an important commercial fermenter of some of our favorite foods—foods such sausage, sauerkraut, kimchi, pickles and other fermented vegetables, adding to their safety, nutritional value and digestibility.

    Sincerely yours,

    Seann Bardell
    BioImmersion.com

    Clinical Note:

    BioImmersion's Original Synbiotic Formula is the gold standard of probiotic formulas.  It contains good bugs (probiotic) and good fiber (prebiotic).  Its five pedigreed lactic acid bacteria are:  L. plantarum, L. acidophilus, L. rhamnosus, S. thermophilus and B. longum. 
    The fiber is:  the soluble fiber from organic chicory root called inulin.  Take 1/4 -1 tsp daily.

    BioImmersion's Beta Glucan High Potency Synbiotic is also a powdered supplement containing probiotic and prebiotic. The probiotics are the same five pedigreed species/strains as are found in the Original. The difference is in its collection of fibers. To the organic inulin we've added organic red beet root fiber and oat bran in which  we've concentrated its soluble beta glucans fibers. Take 1 tsp. to 1tbl, daily.

    For more detail on their feature and benefits click on the valuable links above, which will take you to their individual monographs.

     

    This amazing little creature is a Fennec Fox who lives, as a nocturnal animal, in “of all places” the Sahara Desert.

    The Last Quiz Answer:

    It is an amazing fact about the Komodo dragon, but they were only discovered around 100 years ago.  Today, there is about 4000 dragons on the islands of Komodo, Gila Motang, Rinea and Flores in Indonesia's Lesser Sunda Islands.  Weighting 300 pounds, 10 feet in length these guys don't mess around.  It is always time for dinner and they are omnivorous—deer, pigs, water buffalo and humans are all for dinner.  If their teeth don't kill you their bite will.  Once bitten one dies of septic shock in 24 hours. (National Geographic) 

     

    Green Facts

    It was several years ago when I linked for you —Christian The Lion—the heart wrenching video of a bond between two men and a lion.  It has been viewed and I am sure teared-over by millions.

    Well, here is another amazing video between cross-species friends as they reunite after 5 years of being apart—Damian Aspinali and the wild gorilla Kwibi.

  • Blueberry for CHD, Diabetes and Obesity

    Dear Friends,

    Our most expensive supplement—pure North American Blueberry Extract—is a powerhouse.

    What can the blueberry do? Especially blueberry extract?

    Blueberry extract can reduce the risk of Parkinson's Disease (Lila, 2014); it also reduces inflammation, which reduces the risk of cancer among other diseases (Anand, 2008).

    Research by Vendrome et al. (2013) investigate the power of a wild blueberry enriched diet to improve the proinflammatory status associated with Metabolic Syndrome.

    Metabolic Syndrome has become a major public health problem in the United States.  And, chronic inflammation is a critical component of it, leading to dramatically increased risk of type II diabetes and cardiovascular disease.

    Circulating levels of key inflammatory markers and their expression in the liver and abdominal adipose tissue were examined in obese Zucker rats—tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, C-reactive Protein (CRP), nuclear factor (NF)-kB and adiponectin concentration.  These rats had the classic manifestation of Metabolic Syndrome.

    For 8 weeks they added 8% wild blueberry to the diet—from week 8 to week 16, and this is what they found:  a decrease in plasma concentrations of TNF-alpha by 25.6%; decrease in IL-6 by14.9%; decrease in CRP by 13.1% and an increase in adiponectin concentration by 21.8%.

    Further, expression of IL-6, TNF-alpha and NF-kB was down both the liver (-65%,-59% and -25%, respectively) and the abdominal adipose tissue (-64%, -52% and -65%), while CRP expression was down-regulated only in the liver ( -25%).

    Vendrame et al. 2013. Wild Blueberry (Vaccinium angustifolium) consumption improves inflammatory status in the obese Zucker rat model of the metabolic syndrome. Journal of Nutritional Biochemistry, 24(8), 1508-1512.

    Sincerely yours,

    Seann Bardell
    BioImmersion.com

    Clinical Note:

    BioImmersion's Blueberry Extract supplement contains 60 capsules with 500mg per capsule of pure blueberry extract and nothing else.  There are no excipients of any kind.  The capsule is a vegetarian capsule made from cellulose and water.  Take one capsule per day.

    Our Phyto Power contains wildcrafted blueberries, rosehips (with their seeds) and dandelions (roots, leaves and flowers) rich in a broad spectrum of anti-inflammatory compounds—flavonoids and polyphenols.  Take one to two a day.

     

    This amazing little creature is a Fennec Fox who lives, as a nocturnal animal, in “of all places” the Sahara Desert.

    The Last Quiz Answer:

    The eland is the world's largest antelope.  It's native to more than 15 African countries.  Can live up to 25 years in captivity. Of the population 50% live on protected land. Elands have experienced population decline due to hunting. Their rich milk, tasty meat, and useful hides make elands a useful ranch animal and hunting target. Human populations are growing and expanding into elands' living space and are using up their food sources. (African Wildlife Foundation)

     

    Green Facts

    "We want  to be a part of building a world in which life, human and non-human alike, not only survives but thrives."  See Biomimicry.org.

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