Phyto Power- a wildcrafted wonder
Dear Friends
Phyto Power is comprised of several species of wildcrafted blueberries, Rose hip, and Dandelion, including their leaves, stems, roots, and flowers. Growing wild and strong in remote areas of Alaska, these berries and plants are handpicked at the peak of their phytonutrient potential. For centuries, indigenous tribes of Alaskan Natives have used these power-filled berries and plants for their daily nourishment as well as ceremonial and medicinal purposes.
- Three species of Rosehip, wildcrafted, whole fruit and seeds (100% w/w), refractory dried, three Rosa species, 200mg per capsule.
- Four species of Dandelion, wildcrafted, aerial parts (90% w/w), root (10% w/w) with flower, refractory dried, four Taraxacum species, 200mg per capsule.
- Four species of Blueberry, wildcrafted, fruit (>90% w/w), leaves and stem (<5% w/w), refractory dried, four Vaccinium species, 100mg per capsule.
Food Science
Alaskan wildcrafted berries and plants supply ample antioxidants, anti-inflammatory, and anti-microbial factors (Grace et al., 2014; Youself et al., 2013).
Phyto Power is indeed powerful. In fact, Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.
The Alaskan red Rose hip fruit and seeds, blue-purple Blueberries with twigs and leaves, and the Dandelion’s green leaves, stems, roots and yellow flowers are filled with potent phytonutrients. These vibrant and nutritious phytochemicals protect and enhance the health of both plants and humans (Joseph, Nadeau, & Underwood, 2003). James Duke’s (2000) substantial USDA phytochemical database illustrates the mechanism of the world of plants in the support and maintenance of our health (p. 2).
Scientific evidence links the lack of sufficient nutrients and colorful phytochemicals in our daily diets to the rise of chronic inflammation, one of the causes of metabolic syndrome, which includes cardiovascular, type 2 diabetes, as well as various cancers (Joseph, 2003; Ridker et al., 2000, 2003; Kristo et al., 2016, Ovadje et al., 2016, respectively). For this reason, García-Lafuente et al. (2009) conclude that flavonoids from berries and plants behave as anti-inflammatory agents in our body, calling for more research on the implication of these effects as protection against cancer and cardiovascular issues.
The effect of Blueberries, Rose hip, and Dandelion on Metabolic Syndrome’s risk markers is well documented and researched (Choi et al., 2010; Basu et al., 2012). For example, Andersson et al. (2011) demonstrated in a randomized, double-blind, crossover study* with 31 obese individuals that daily consumption of rose hip (drink) significantly decreased plasma cholesterol and systolic blood pressure, effectting the risk markers of type 2 diabetes and cardiovascular disease. In 2012, Andersson et al. conducted a study with lean and obese mice that were fed high-fat diet and a dietary supplement of rose hip powder. The supplement of rose hip prevented and reversed the increase in body weight. Andersson et al. (2012) concluded that rose hip supports the prevention of diabetic state in the mouse and that downregulation of the hepatic lipogenic program is one of the mechanisms underlying this antidiabetic effect.
Choi et al.’s (2010) demonstrated that supplementing rabbits that are fed with high cholesterol diets with dandelion leaf and root positively changed plasma antioxidant enzyme activities and lipid profiles, offering “hypolipidemic and antioxidant effects.”
These research findings are not new amongst scientists. Johnson et al. (1994) discovered that plants and their biologically active constituents contribute protective and anti-carcinogenic effects (Table 1, p. 193). These ‘dietary phytoprotectants’ in foods (p. 194) have continually shown in research to impart an important anti-inflammatory effect (Vendrame et al., 2015; Joseph et al., 2014), act as powerful anti-oxidants (Jedrejek et al., 2017; Skrovankova et al., 2015), and offer protection and inhibition of certain cancers (Zhan et al., 2016; Yang & Li, 2015; Li et al., 2009; Seeram, 2008; Sigstedt et al., 2008).
Although the exact mechanisms and reasons (the why) of these promising effects are still in the process of discovery, the findings suggest a regular habit of dietary supplementation with these plants and berries.
Blueberries, Rose hip, and Dandelion demonstrate in research a potential effect on different cancers. For example, blueberries are shown to inhibit growth and metastatic potential (Adams et al., 2010; Liu et al., 2013), and manage gastrointestinal tract cancers (Bishayee et al., 2016). Rose hip has shown to effect human brain cell proliferation (Cagle et al., 2012) and offer antiproliferation effect on Caco-2 human colon cancer (Jiménez et al., 2016). Dandelion was found to induce apoptosis in drug-resistant human melanoma cells (Chatterjee et al., 2011; see also Jeon et al., 2008 and Hu et al., 2003 for further reading on dandelion).
The Rose hip has a rich phytochemical profile shown to also support many different mechanisms in the human body. For example, the red berry of Rose hip is known for its antioxidant protection (Widen et al., 2012), supporting weight loss by a possible mechanism of decreasing abdominal visceral fat (Nagatomo et al., 2015). Andersson et al. (2011) examined the Rose hip antidiabetic effect, as well as the effect of Rose hip on risk markers of type 2 diabetes and cardiovascular disease in obese persons (Andersson et al., 2012). Rose hip is also found to support the liver (Nagatomo et al., 2013; Sadeghi et al., 2016), and offer relief from joint pain (Christensen et al., 2008; Willich et al., 2010; Winther et al., 2005).
For further study of the Rosa canina see Chrubasik et al. for a systemic review and clinical efficacy of the Rose hip (2008; 2006, respectively).
Dandelion is shown to have a great antioxidant activity (Hu et al., 2003), exhibiting diverse biological activities that promote energy, weight loss, and reduced risk of metabolic syndrome (Jedrejek et al., 2017; González-Castejón et al., 2012; Jeon et al., 2008). Ovadje et al. (2016) conclude that dandelion root extract effects colorectal cancer proliferation which may occur through the activation of ‘multiple death signalling pathways,’ and a selective induction of apoptosis and autophagy in human pancreatic cancer cells (2012; 2012a). Signstedt (2008) found similar results with extract of Taraxacum officinale on the growth and invasion of breast and prostate cancer cells, while Yang et al. (2015) demonstrated that Dandelion extract protects human skin fibroblasts from uvb damage.
For further study of the Taraxacum (Dandelion), see Schütz, Carle, & Schieber (2006) for a systemic review on its phytochemical and pharmacological profile.
Blueberries are rich with anthocyanins and a wide variety of phytochemicals that have been shown to effect neuro-generation (Albarracin et al., 2012). Studies are showing that a neuro-generative effect also occurs with Parkinson (Chao et al., 2012; Gao et al., 2012; Strathearn et al., 2014). Blueberries regenerate neuronal aging (Shukitt-Hale, 2012), and support memory (Krikorian et al., 2010). For more on nerve regeneration, see the Research tab of Blueberry Extract.
A daily consumption of blueberries is shown to support a lower blood pressure and arterial stiffness (Johnson et al., 2015), increase natural killer cell counts (McAnulty et al., 2014), down-regulate hepatic lipogentic program (Andersson et al., 2011), and impact insulin resistance and glucose intolerance (Stull, 2016). Zhan et al. (2016) discovered the importance of blueberries on the migration, invasion, proliferation of hepatocellular carcinoma cells. Yang et al. has shown in 2001 the inhibition of carcinogenesis by dietary polyphenolic compounds.
These impressive findings support dietary supplementation with berries as a healthy approach to various Metabolic Syndrome concerns, including cancer (Vendrame et al., 2015; Seeram, N.P., 2008; Seeram et al., 2006, respectively).
The hormetic mechanism of phyto-nutrients is an exciting area of research. Scientists have discovered that small amounts of phytochemicals offer much more than nutrients. Phytochemicals offer a hormetic mechanism; a stimulation of many pathways in our body that prevents, repairs, or reverses aging and disease (Lee et al., 2014; Davinelli et al., 2012). The concept of hormesis is defined as an adoptive response of cells and organism to low dosages of phytochemicals. This adoptive response stimulates a beneficial effect in the body (Mattson, 2008, 2008a). Calabrese et al. conducted many studies on hormetic phytochemicals and vitagenes in aging and longevity, including the effect of antioxidants such as polyphenols on neuro-generation (2012, 2011, 2009). The vitagene network of genes involved in the process of repair and maintenance is thought of as the longevity assurance processes (Rattan, 2004, 1998).
Phyto Power as a dietary supplement offers a regular serving of several species of Blueberries, Rose hip, and Dandelion, including the leaves, stems, flower, and root.
See the Research tab for additional bibliography to further understand the research, findings, application and use of Blueberries, Rose hip, and Dandelion. Visit Resources on the tool bar to find helpful protocols (Library) and summaries (News).
*Double blind, crossover study: in a double blind study A study the participants and those in contract with them (assistants) are blind to the details of the study. A crossover is when at one point in the study the participants switch from taking an active substance (such as rose hip in the Andersson study) to a placebo or vice versa.
References:
Adams, L.S., Phung, S. Yee, N., Sheeram, N.P., Li, L., & Chen, S. (2010). Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res, 70(9), 3594-605. DOI: 10.1158/0008-5472.CAN-09-3565
Albarracin, S.L., Stab, B., Casas, Z., Sutachan, J.J., Samudio, I., Gonzalez, J….Barreto, G.E. (2012). Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci, 15, 1–9. DOI:10.1179/1476830511Y.0000000028
Andersson, U., Berger, K., Hogberg, A., Landin-Olsson, M., & Holm, C. (2012). Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr, 66, 585–590. DOI:10.1038/ejcn.2011.203
Andersson, U., Henriksson, E., Strom, K., Alenfall, J., Goransson, O., Holm, C. (2011). Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program. Am J Physiol Endocrinol Metab, 300, E111–121. DOI:10.1152/ajpendo.00268.2010
Basu, A., & Lyons, T.J. (2012). Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives. J Agric Food Chem, 60: 5687-92. DOI:10.1021/jf203488k
Bishayee, A., Haskell, Y., Do, C., Siveen, K.S., Mohandas, N., Sethi, & G., Stoner, G.D. (2016). Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence. Crit Rev Food Sci Nutr, 56(10), 1753-75. DOI: 10.1080/10408398.2014.982243
Cagle, P., Idassi, O., Carpenter, J., Minor, R., Goktepe, I., & Martin, P. (2012). Effect of Rosehip (Rosa canina) extracts on human brain tumor cell proliferation and apoptosis. Journal of Cancer Therapy, 3(5), 13. . DOI:10.4236/jct.2012.35069
Calabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Iavicoli, I., Di Paola, R., Koverech, A. … Calabrese, E.J. (2012). Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta, 1822(5), 753-83. DOI:10.1016/j.bbadis.2011.11.002
Calabrese, V., Cornelius, C., Cuzzocrea, S., Iavicoli, I., Rizzarell,i E., Calabrese, E.J. (2011). Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity. Mol Aspects Med, 32(4-6):279-304. DOI:10.1016/j.mam.2011.10.007
Calabrese, V., Cornelius, C., Mancuso, C., Barone, E., Calafato, S., Bates, T., Rizzarelli, E., Kostova, A.T. (2009). Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases. Front Biosci, 14, 376-397. Abstract
Chao, J., Leung, Y., Wang, M., & Chang, R.C. (2012). Nutraceuticals and their preventive or potential therapeutic value in Parkinson’s disease. Nutr Rev, 70, 373–86. DOI:10.1111/j.1753-4887.2012.00484.x.
Chatterjee, S.J., Ovadje, P. Mousa, M., Hamm, C., & Pandey, S. (2011). The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells. Evid Based Complement Alternat Med, 129045. DOI:10.1155/2011/129045
Choi, U.K., Lee, O.H., Yim, J.H., Ch,o C.W., Rhee, Y.K., Lim, S.I., & Kim, Y.C. (2010). Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits. Int Mol Sci, 11(1), 67-78. doi:10.3390/ijms11010067.
Christensen, R., Bartels, E.M., Altman, R.D., Astrup, A., Bliddal, H. (2008). Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients?–a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage, 16, 965–972. DOI:10.1016/j.joca.2008.03.001
Chrubasik, C., Roufogalis, B.D. Muller-Lander, U., & Chrubasik, S. (2008). A systematic review on the Rosa canina effect and efficacy profiles. Phytother Res, 22(6), 725-33. DOI:10.1002/ptr.2400
Chrubasik, C., Duke, R.K., Chrubasik, S. (2006). The evidence for clinical efficacy of rose hip and seed: a systematic review. Phytother Res, 20(1), 1-3. DOI:10.1002/ptr.1729
Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI:
10.3402/ijch.v72i0.21188
Davinelli, S., Willcox, D.C., & Scapagnini, G. (2012). Extending healthy aging: nutrient sensitive pathway and centenarian population. Immun Ageing, 9, 9. DOI:10.1186/1742-4933-9-9.
Gao, X., Cassidy, A., Schwarzschild, M.A., Rimm, E.B., & Ascherio, A. (2012). Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology, 78, 1138–45. doi: 10.1212/WNL.0b013e31824f7fc4
García-Lafuente, A., Guillamón, E., Villares, A., Rostagno, M.A., & Martínez, J.A. (2009). Flavonoids as antiinflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res, 58, 537–552. DOI:10.1007/s00011-009-0037-3
Gonzalez-Castejon, M., Visioli, F., & Rodriguez-Casado, A. (2012). Diverse biological activities of dandelion. Nutr Rev, 70(9), 534-47. DOI:10.1111/j.1753-4887.2012.00509.x
Grace, M.H., Esposito D., Dunlap K.L., & Lila M.A. (2014). Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries. J Agric Food Chem, 62(18), 4007-17. doi:10.1021/jf403810y.
Hu, C., & Kitts, D.D. (2003). Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro. Journal of Agricultural and Food Chemistry, 51, (1), 301–310. DOI:10.1021/jf0258858
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Jedrejek, D., Kontek, B., Lis, B., Stochmal, A., Olas, B. (2017). Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2/Fe. Chem Biol Interact, 262, 29-37. DOI: 10.1016/j.cbi.2016.12.003
Jeon, H.J., Kang, H. J., JungH.J. Kant, Y.S., Lim, C.J., Kim, Y.M., & Park, E.H. (2008). Anti-inflammatory activity of Taraxacum officinale. Journal of Ethnopharmacology, 115 (1), 82–88. DOI:10.1016/j.jep.2007.09.006
Jiménez, S., Gascón, S., Luquin, A., Laguna, M., Ancin-Azpilicueta, C., Rodríguez-Yoldi, M.J. (2016). Rosa canina Extracts Have Antiproliferative and Antioxidant Effects on Caco-2 Human Colon Cancer. PLoS One, 11(7), e0159136. https://doi.org/10.1371/journal.pone.0159136
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Johnson, S.A., Figueroa, A., Navae, N. Wong, A., Ralfon, R., Ormsbee, L.T…. Arjmandi, B.H. (2015). Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial. J. Acad Nutr Diet, 115(3), 369-77. DOI:10.1016/j.jand.2014.11.001
Joseph, S.V., Edirisinghe, I., & Burton-Freeman, B.M. (2014). Berries: anti-inflammatory effects in humans. J Agric Food Chem, 7; 62(18), 3886-903. DOI:10.1021/jf4044056
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Kristo, A.S., Klimis-Zacas, D., Sikalidis, A.K. (2016). Protective Role of Dietary Berries in Cancer. Antioxidants (Basel), 5(4), 37. doi:10.3390/antiox5040037
Krikorian, R., Shidler, M.D., Nash, T.A., Kalt, W., Vingvist-tymchuk, M.R., Shukitt-Hale, B., Joseph, J.A. (2010). Blueberry supplementation improves memory in older adults. J. Agric Food Chem, 58, 3996-4000. DOI:10.1021/jf9029332
Lee, J., Jo, D.G., Park, D., Chung, H.Y., Mattson, M.P. (2014). Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system.
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Li, L., Adams, L.S., Chen, S., Killan, C., Ahmed, A., & Seeram, N.P. (2009). Eugenia jambolana Lam. [purple berries] berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. J Agric Food Chem, 57(3), 826-31. DOI:10.1021/jf803407q
Liu, W., Lu, X., He, G., Gao, X., Xu, M., Zhang, J… Luo, C. (2013). Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. Int Mol Sci, 14(11), 21447-62. DOI:10.3390/ijms141121447
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McAnulty, L.S., Collier, S.R., Landram, M.J., Whittaker, D.S., Isaacs, S.E., Klemka, J.M… McAnulty, S.R. (2014). Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females. Nutr Res, 34(7), 577-84. DOI:10.1016/j.nutres.2014.07.002
Nagatomo, A., Nishida, N., Fukuhara, I., Noro, A., Kozai, Y., Sato, H., & Matsuura, Y. (2015). Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial. Diabetes Metab Syndr Obes, 8, 147–156. DOI:10.2147/DMSO.S78623
Nagatomo, A., Nishida, N., Matsuura, Y., & Shibata, N. (2013). Rosehip Extract Inhibits Lipid Accumulation in White Adipose Tissue by Suppressing the Expression of Peroxisome Proliferator-activated Receptor Gamma. Prev Nutr Food Sci, 18, 85–91. doi: 10.3746/pnf.2013.18.2.085
Ovadje, P., Ammar, S., Guerrero, J.A., Arnason, J.T., Pandey, S. (2016). Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways. Oncotarget, 7(45):73080-73100. DOI:
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Ovadje, P., Chochkeh, M., Akbari-Asl, P., Hamm, C., Pandey, S. (2012). Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells. Pancreas, 41(7), 1039-47. DOI: 10.1097/MPA.0b013e31824b22a2
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Sadeghi, H., Hosseinzadeh, S., Akbartabar Touri, M., Ghavamzadeh, M., Jafari Barmak, M., Sayahi, M., & Sadeghi, H. (2016). Hepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat. Avicenna J Phytomed, 6(2), 181-8. DOI: 10.22038/ajp.2016.5481
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Zhan, W., Liao, X., Yu, L., Tian, T., Liu, X, Liu, J., … Yang, Q. (2016). Effects of blueberries on migration, invasion, proliferation, the cell cycle and apoptosis in hepatocellular carcinoma cells. Biomed Rep, 5(5), 579-584. DOI:
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Article by Dohrea Bardell, PhD.
Sincerely yours,
Seann
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.Green Facts:
 Understanding the concept of hormesis and its relationship to plant phytonutrients opens the door to a whole new medical paradigm for reducing chronic oxidative stress. Chronic oxidative stress increases cancer, metabolic and neurodegenerative disease risk.
See Callbrese et al. (2010) illuminating paper on this most important concept: |
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