Beta-Glucan Synbiotic

We are proud to have the Beta Glucan qualifies for the American Heart Association and the FDA "Heart Healthy" seal of approval: improving lipid serum levels.*

The special heat-shearing technology used to liberate the beta-glucans from the oat is patented (US Patent # 6,060,519), and considered by the FDA as a gluten free ingredient (99.98% gluten free). For our gluten sensitive friends, please consult your doctor.*

The food ingredients in the Beta Glucan formula are chosen carefully for their highest phytonutrient potential. The proprietary mix contains: Organic matrix USDA patented hydrocolloidal beta glucan oat bran (75%), organic whole red beetroot (15%), and organic inulin from chicory fiber (10%). Advances in microbiome research and technology allow us to grow our hardy and viable pedigreed Original probiotic strains. Our high potency Original probiotics, along with the B-Glucans, Beetroot, and Inulin offer heart healthy properties, GI support with plant fibers and probiotics, weight-management, regularity, and a boost in energy.*

Oats and oat beta glucan have enjoyed a rich cultural historicity and extensive research on heart health (Andersson & Hellstrand, 2012). From Shaper & Jones (1959) analysis of healthy dietary habits, to the Cornell China study in 1998, and the NIH report in 2015, dietary fibers, whole plant-based foods, and exercise are shown in research to be essential for a healthy heart. Oats and oat beta glucan are found to reduce serum LDL cholesterol (Ho et al., 2016; Zhu et al., 2015; Whitehead et al., 2014; Wolever et al., 2010), improve liver function (Chang et al., 2013), and promote bowel regularity (Clemens, 2012; Mobley et al., 2014).*

Red beetroot offer a rich source of phyto-nutrients, including ascorbic acid (vitamin C), carotenoids, phenolic acids, and flavonoids. Beets provide a source of dietary nitrate, shown in research to have important implication for heart health (Kapil et al., 2014). Beet’s nutrients are shown to prevent oxidation of LDLs, lower triglycerides, and balances blood pressure (Clifford et al., 2015; Eggenbeen et al., 2016; Hobbs et al., 2013). As a multifunctional food, beet also stimulate Phase II liver detox (Vulić et al., 2014), as well as perform a host of other health benefits, including the production of energy for exercise (Murphy et al., 2012), promotion of joint health (Pietrzkowski et al., 2010), Antioxidant (Georgiev et al., 2010), and support for individuals who undergo cancer treatments (Kapadia et al., 2013, 2011; Das et al., 2013).*

The Beta Glucan formula is comprised of our BioImmersion Probiotic Master Blend – Probiotics- Lactobacillus acidophilus, Lactobacillus casei rhamnosus, Lactobacillus plantarum, Streptococcus thermophilus, Bifidobacterium longum; Supernatant- probiotic metabolites, and ORNs.  65 billion CFU.  The Beta Glucans strains of lactic acid bacteria are pedigreed and certified, based on ATCC prototypical strains and confirmed routinely by 16sRNA sequencing to provide highest quality probiotic material. Our strains are hardy, strong, and effective.*

Probiotics are found in research to positively effect heart health (Kassaian et al., 2017; Sáez-Lara et al., 2016; DiRienzo, 2014; Delzenne et al., 2011; Saini et al., 2010), with many researchers positing the connection between heart and gut health (Serino et al., 2014; Huang et al., 2013). The Beta Glucan was formulated to nourish both heart and gut into health.*

Inulin from organic chicory root supplies food for the probiotic organisms. Probiotic organisms need fiber to grow and multiply. See Slavin (2013) on fiber as prebiotics, and Dehghan et al. (2013) on inulin and cardiovascular support.*

Together with probiotic, inulin is also found in research to help tighten cell junctions, which is thought to aid against leaky gut syndrome (Cani et al., 2007, 2007a, 2008, 2009).*

The Beta Glucan formula is utilized for bowel regulation. Plant fiber and gluten free whole oat fiber are shown to increase bowel regularity (Schmier et al., 2014).*

The Beta Glucan is multifunctional due to its oat beta glucans, red beetroot, inulin from chicory, and strong probiotic organism. Each ingredient is shown in research to offer heart healthy food, boost energy, and support the GI tract, liver and kidneys, promoting regularity and GI comfort. Take a look at the food science tab to see the bibliography and engage in learning more about the many health applications scientists have discovered over the years. The tab only shows a fraction of the research findings on oat beta glucan, probiotics, red beetroot, and inulin.*

See the Research tab for additional bibliography to further understand the application and use of beta glucan, red beetroot, inulin, and probiotics.

*These statements have not been evaluated by the Food & Drug Administration. This products is not intended to diagnose, treat, cure or prevent any disease. The information and citations of research are for informational purposes only. Please be sure to consult your health care provider before taking this or any other product.

REFERENCES

Anderson, K.E., & Hellstrand, P. (2012). Dietary oats and modulation of atherogenic pathways. Mol Nutr Food Res, 56(7), 1003-13. DOI: 10.1002/mnfr.201100706

Cani, P.D., Pssemiers, S., Van de Wiele, T., Guiot, Y., Everad, A., Rottier, O…. Delzenne, N.M. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut, 58(8), 1091-1103. DOI: 10.1136/gut.2008.165886

Cani, P.D., Bibiloni, R., Knauf, C., waget, A., Neyrinck, A.M., Delzenne, N.M., Burcelin, R. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice. Diabetes, 57, 1470-8. DOI: 10.2337/db07-1403

Cani, P.D., Amar, J., Iglesias, M.A., Poggi, M., Knauf, C., Bastelica, D. … Burelini, R. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 56, 1761-72. DOI: 10.2337/db06-1491

Cani, P.D., Neyrinck, A.M., Fava, F., Knauf, C., Burcelin, R.G., Tuohy, K.M. … Delzenne, N.M. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia, 50, 2374-83. DOI: 10.1007/s00125-007-0791-0

Chang, H.C., Huang, C.N., Yeh, D.M., Wang, S.J., Peng, C.H., & Wang, C.J. (2013). Oat prevents obesity and abdominal fat distribution, and improves liver function in human. Plant Foods Hum Nutr, 68(1), 18-23. DOI: 10.1007/s11130-013-0336-2

Clemens, R., Kranz, S., Mobley, A.R., Nicklas, T.A., Raimondi, M.P., Rodriguez, J.C., … Warshaw, H. (2012). Filling American’s fiber intake gap: Summary of roundtable to probe realistic solutions with a focus on grain-based foods. J Nutr, 142(7), 1390-1401. DOI: 10.3945/jn.112.160176

Clifford T, Howatson G, West DJ, Stevenson EJ. (2017). Beetroot Juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. DOI: 10.1139/apnm-2017-0238

Clifford, T., Howatson, G., West, D.J., Stevenson, E.J. (2015). The potential benefits of red beetroot supplementation in health and disease.Nutrients,7(4):2801-22. DOI: 10.3390/nu7042801

Das, S., Fillippone, S.M., Williams, D.S., Das, A., Kukreja, R.C. (2016). Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells. Mol Cell Biochem, 421(1-2), 89-101. DOI: 10.1007/s11010-016-2789-8

Das, S., Williams, D.S., Das, A., Kukreja, R.C. (2013). Beet root juice promotes apoptosis in oncogenic MDA-MB-231 cells while protecting cardiomyocytes under doxorubicin treatment. J. Exp. Second. Sci, 2, 1–6. Abstract

Dehghan, P., Pourghassem, G.B, & Asgharijafarabadi, M. (2013). Effects of high performance inulin supplementation on glycemic status and lipid profile in women with type 2 diabetes: a randomized, placebo-controlled clinical trial. Health Promot Perspect, 3(1), 55-63. DOI: 10.5681/hpp.2013.007

Delzenne, N.M., Neyrinck, A.M., Cani, P.D.(2011). Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microb Cell Fact, 10 Suppl 1, S10. DOI: 10.1186/1475-2859-10-S1-S10

DiRienzo D.B. (2014). Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets. Nutr Rev, 72(1), 18-29. DOI: 10.1111/nure.12084

Domínguez R, Cuenca E, Maté-Muñoz JL, García-Fernández P, Serra-Paya N, Estevan MC, Herreros PV, Garnacho-Castaño MV.(2017). Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review. Nutrients, 9(1).DOI: 10.1016/j.jand.2011.12.002

Eggenbeen, J., Kim-Shapiro, D.B., Haykowsky, M., Morgan, T.M., Basu, S., Brubaker, P., … Kitzman, D.W. (2016). One week of daily dosing with beetroot juice improves submaximal endurance and blood pressure in older patients with heart failure and preserved ejection fraction. JACC Heart Fail, 4(6), 428-37. DOI: 10.1016/j.jchf.2015.12.013

Georgiev, V.G., Weber, J., Kneschke, E.M., Denev, P.N., Bley, T., Pavlov, A.I. (2010). Antioxidant activity and phenolic content of betalain extracts from intact plants and hairy root cultures of the red beetroot Beta vulgaris cv. Detroit dark red. Plant Foods Hum Nutr, 65 (2):105-11. DOI: 10.1007/s11130-010-0156-6

Ho, H.V., Sievenpiper, J.L., Zurbau, A., Blanco Mejia, S., Jovanovski, E., Au-Yeung, F… Vuksan, V. (2016). The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials. Br J Nutr. 116(8):1369-1382. DOI: 10.1017/S000711451600341X

Hobbs, D.A., George, T.W., Lovegrove, J.A. (2013). The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies. Nutr Res Rev, 26(2), 210-22. DOI: 10.1017/S0954422413000188

Huang, Y., Wang, X., Wang, J., Wu, F., Sui, Y., Yang, L., Wang, Z. (2013). Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity. J Dairy Sci, 96(5), 2746-53.DOI: 10.3168/jds.2012-6123

Kapadia, G.J., Rao, G.S., Ramachandran, C., Iida, A., Suzuki, N., & Tokuda, H. (2013). Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines. J Complement Integr Med., 1. DOI: 10.1515/jcim-2013-0007

Kapadia, G.J., Azuine, M.A., Rao, G.S, Arai, T., Lida, A., & Tokuda, H. (2011), Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines. Anticancer Agents Med Chem, 11(3), 280-4. Abstract

Kapil, V., Weitzberg, E., Lundberg, J.O., Ahluwalia, A. (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health. Nitric Oxide, 38, 45-57. DOI: 10.1016/j.niox.2014.03.162

Kassaian, N., Aminorroaya, A., Feizi, A., Jafari, P., Amini, M. (2017). The effects of probiotic and synbiotic supplementation on metabolic syndrome indices in adults at risk of type 2 diabetes: study protocol for a randomized controlled trial. Trial, 18(1), 148. DOI: 10.1186/s13063-017-1885-8

Mobley, A.R., Jones, J.M., Rodriguez, J., Slavin, J., & Zelman, K.M. (2014). Identifying practical solutions to meet American’s fiber needs: Proceedings from the Food & Fiber Summit. Nutrients, 8(7), 2540-51. DOI: 10.3390/nu6072540

Murphy, M., Eliot, K., Heuertz, R.M., Weiss, E. (2012). Whole beetroot consumption acutely improves running performance. J Acad Nutr Diet , 112(4), 548-52. DOI: 10.1016/j.jand.2011.12.002

Sáez-Lara, M.J., Robles-Sanchez, C., Ruiz-Ojeda, F.J., Plaza-Diaz, J., Gil, A.(2016). Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials. Int J Mol Sci, 17(6).DOI: 10.3390/ijms17060928

Saini, R., Saini, S., & Sharma, S. (2010). Potential of probiotics in controlling cardiovascular diseases. J. Cardiovasc Dis Res,1(4), 213-214. DOI: 10.4103/0975-3583.74267

Schmier, J.K., Miller, P.E., Levine, J.A., Perez, V., Maki, K.C., Rains, T.M., … Alexander, D.D. (2014). Cost savings reduced constipation rates attributed to increased dietary fiber intakes: A decision-analytic model. BMC Public Health, 14-374. DOI: 10.1186/1471-2458-14-374

Serino, M., Blasco-Baque, V., Nicolas, S., & Burcelin, R. (2014). Far from the Eyes, Close to the Heart: Dysbiosis of Gut Microbiota and Cardiovasuclar Consequences. Curr Cardiol Rep, 16(11), 540. DOI: 10.1007/s11886-014-0540-1

Shaper, A.G., & Jones, K.W. (1959). Serum-cholesterol, diet, and coronary heart disease in Africans, and Asians in Uganda.The Lancet, 275(7102), 534-37. DOI: 10.1093/ije/dys137

Slavin, J. (2013). Fiber and prebiotics: mechanism and health benefits.Nutrients, 5(4), 1417-1435. DOI: 10.3390/nu5041417

Vulić J.J., Ćebović T.N., Čanadanović-Brunet J.M., Ćetković G.S., Čanadanović V.M., Djilas S.M., Tumbas Šaponjac V.T. In vivo and in vitro antioxidant effects of beetroot pomace extracts. J. Funct. Foods. 2014;6:168–175. https://doi.org/10.1016/j.jff.2013.10.003

Whitehead A, Beck EJ, Tosh S, Wolever TM. (2014). Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials. Am J Clin Nutr, 100(6), 1413-21.DOI: 10.3945/ajcn.114.086108

Wolever TM, Tosh SM, Gibbs AL, Brand-Miller J, Duncan AM, Hart V, Lamarche B, Thomson BA, Duss R, Wood PJ (2010). Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial. Am J Clin Nutr, 92(4):723-32. DOI: 10.3945/ajcn.2010.29174

Zhu, X., Sun, X., Wang, M., Zhang, C., Cao, Y., Mo, G., Liang, J., Zhu, S. (2015).Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects. Nutr Metab Cardiovasc Dis, 25(8), 714-23.DOI: 10.1016/j.numecd.2015.04.008

FOOD SCIENCE: THE APPLICATION AND USE OF BETA GLUCAN, RED BEETROOT, CHICORY FIBER, AND PROBIOTICS.*

Cardiovascular Health

Anderson, J.W. (2004). Whole grains and coronary heart disease: the whole kernel of truth. Am J clin Nutr, 80(6), 1459-60. Article

Anderson, K.E., & Hellstrand, P. (2012). Dietary oats and modulation of atherogenic pathways. Mol Nutr Food Res, 56(7), 1003-13. DOI: 10.1002/mnfr.201100706

Benjamin M.M., & Roberts, W.C. (2013). Facts and principles learned at the 19^th Annual Williamsburg Conference on Heart Disease. Proc (Bayl Univ Med Cent), 26(2), 124-36. Articles

Campbell T.C., Parpia, B., & Chen, J. (1998). Diet, lifestyle, and the etiology of coronary artery disease: the Cornell China Study.Am J Cardio, 82(10B), 18T-21T. Abstract

De Biase, S.G., Fernandes, S.F., Gianini, R.J., & Duarte, J.L. (2007). Vegetarian diet and cholesterol and triglycerides levels.Arq. Bras Cardiol, 88(1), 35-9. Abstract

DiRienzo D.B. (2014). Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets. Nutr Rev, 72(1), 18-29. DOI: 10.1111/nure.12084

Erkkila, A.T., Herrington, D.M., Mozaffarian, D., & Lichtenstein, A.H. (2005). Cereal fiber and whole-grain intake are associated with reduced progression of coronary-artery atherosclerosis in postmenopausal women with coronary artery disease. Am Heart J, 150(1), 94-101. DOI: 10.1016/j.ahj.2004.08.013

Esslestyn, C.B. (2010). Is the present therapy for coronary artery disease the radical mastectomy of the twenty-first century? Am J Cardiol, 106(6), 902-4. DOI: 10.1016/j.amjcard.2010.05.016

Food and Drug Administration. (2002). Food labeling: health claims; soluble dietary fiber from certain foods and coronary heart disease. Interim final rule. Food and Drug Administration, HHS.. Fed Regist, 67(191), 61773-83. Abstract

Hartley, L., May, M.D., Loveman, E., Colquitt, J.L., Rees, K. (2016). Dietary fibre for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev, (1), CD011472. DOI: 10.1002/14651858.CD011472.pub2

Ho, H.V., Sievenpiper, J.L., Zurbau, A., Blanco Mejia, S., Jovanovski, E., Au-Yeung, F… Vuksan, V. (2016). The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials. Br J Nutr. 116(8):1369-1382. DOI: 10.1017/S000711451600341X

Lambeau, K.V., McRorie, J.W. Jr. (2017).Fiber supplements and clinically proven health benefits: How to recognize and recommend an effective fiber therapy. J Am Assoc Nurse Pract, 29(4), 216-223. DOI: 10.1002/2327-6924.12447

Myerburg, R.J., & Junttila M.J. (2012). Sudden cardiac death cause by coronary heart disease. Circulation 28, 125 (8), 1043-52. DOI: 10.1161/CIRCULATIONAHA.111.023846

NIH (2015). Coronary Heart Disease. National Heart, lung, and Blood Institute; nhibi.hih.gov/health-topics/cad. Article

Ornish, D., Scherwitz, L.W., Billings, J.H., Brown, S.E., Gould, K.L., Merritt, T.A., … Brand, R.J. (1998). Intensive lifestyle changes for reversal of coronary heart disease. JAMA, 285(8), 2001-7. Abstract

Othman RA, Moghadasian MH, Jones PJ. (2011).Cholesterol-lowering effects of oat β-glucan. Nutr Rev, 69(6):299-309. DOI: 10.1111/j.1753-4887.2011.00401.x

Reyna-Villasmil, N., Bermudez-Pirela, V., Mengual-Moreno, E., Arias, N., Cano-Ponce, C., Leal-Gonzlez, E…. Arraiz, N. (2007). Oat-derived beta-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individuals with mild hypercholesterolemia. Am J Ther, 14(2), 203-12. DOI: 10.1097/01.pap.0000249917.96509.e7

Shaper, A.G., & Jones, K.W. (1959). Serum-cholesterol, diet, and coronary heart disease in Africans, and Asians in Uganda.The Lancet, 275(7102), 534-37. DOI: 10.1093/ije/dys137

Singh, R., De, S., & Belkheir, A. (2013) Avena sativa (oat), a potential neutraceutical and therapeutic agent: An Overview. Criti rev Food sci Nutr, 53(2), 126-44. DOI: 10.1080/10408398.2010.526725

Streppel, M.T., Ocke, M.C., Boshuizen, H.C., Kok, F.J., & Kromhout, D. (2008). Dietary fiber intake in relation to coronary heart disease and all-cause mortality over 40 y: the Zutpehn study. Am J Clin Nur, 88, 1119-25. DOI: 10.3945/ajcn.2010.29417

Tiwari, U., & Cummins, E. (2011). Meta analysis of the effect of β-glucan [from oats] intake on blood cholesterol and glucose levels. Nutrition, 27(10), 1008-16. DOI: 10.1016/j.nut.2010.11.006

Tighe, P., Duthie, G., Vaughan, N., Brittenden, J., Simpson, W.G., Duthie, S…. Thies, F. (2010). Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial. Am J Clin Nutr , 92, 733-40. DOI: 10.3945/ajcn.2010.29417

Trowell, H. (1972). Ischemic heart disease and dietary fiber.Am J Clin Nutr, 25(9), 962-32. Abstract

Trumbo, P.R., & Shimakawa T. (2011). Tolerable upper intake levels for trans fats, saturated fat, and cholesterol. Nutr Res, 69(5), 270-5. DOI: 10.1111/j.1753-4887.2011.00389.x

Vogel, R.A., Corretti, M.C., & Plotnick, G.D. (1997). Effect of a single high-fat meal on endothelial function in healthy subjects.Am J Cardiol, 79(3), 350-4. Abstract

Whitehead A, Beck EJ, Tosh S, Wolever TM. (2014). Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials. Am J Clin Nutr, 100(6), 1413-21.DOI: 10.3945/ajcn.114.086108

Wolever TM, Gibbs AL, Brand-Miller J, Duncan AM, Hart V, Lamarche B, Tosh SM, Duss R. (2011).Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians. Nutr J, 10:130. DOI: 10.1186/1475-2891-10-130

Wolever TM, Tosh SM, Gibbs AL, Brand-Miller J, Duncan AM, Hart V, Lamarche B, Thomson BA, Duss R, Wood PJ (2010). Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial. Am J Clin Nutr, 92(4):723-32. DOI: 10.3945/ajcn.2010.29174

Zhu, X., Sun, X., Wang, M., Zhang, C., Cao, Y., Mo, G., Liang, J., Zhu, S. (2015).Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects. Nutr Metab Cardiovasc Dis, 25(8), 714-23.DOI: 10.1016/j.numecd.2015.04.008

Oat and Prebiotic Fiber: Fatty Liver Support

Chang, H.C., Huang, C.N., Yeh, D.M., Wang, S.J., Peng, C.H., & Wang, C.J. (2013). Oat prevents obesity and abdominal fat distribution, and improves liver function in human. Plant Foods Hum Nutr, 68(1), 18-23. DOI: 10.1007/s11130-013-0336-2

Druart, C., Alligier, M., Salazar, N., Neyrinck, A.M., Delzenne, N.M. (2014).Modulation of the gut microbiota by nutrients with prebiotic and probiotic properties. Adv Nutr, 5 (5):624S-633S. DOI: 10.3945/an.114.005835

Eslamparast, T., Poustchi, H., Zamani, F., Sharafkhah, M., Malekzadeh, R., Hekmatdoost, A. (2014).Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study. Am J Clin Nutr, 99(3), 535-42.DOI: 10.3945/ajcn.113.068890

Kieffer, D.A., Martin, R.J., Adams, S.H. (2016). Impact of Dietary Fibers on Nutrient Management and Detoxification Organs: Gut, Liver, and Kidneys.Adv Nutr, 7(6), 1111-1121.DOI: 10.3945/an.116.013219

Kirpich, I.A., Marsano, L.S., McClain, C.J. (2015). Gut-liver axis, nutrition, and non-alcoholic fatty liver disease. Clin Biochem, 48 (13-14), 923-30. DOI: 10.1016/j.clinbiochem.2015.06.023

Lambert, J.E., Parnell, J.A., Eksteen, B., Raman, M., Bomhof, M.R., Rioux, K.P., Madsen, K.L., Reimer, RA. (2015). Gut microbiota manipulation with prebiotics in patients with non-alcoholic fatty liver disease: a randomized controlled trial protocol. BMC Gastroenterol, 15,169. DOI: 10.1186/s12876-015-0400-5

Leung, C., Rivera, L., Furness, J.B., Angus, P.W. (2016). The role of the gut microbiota in NAFLD. Nat Rev Gastroenterol Hepatol, 13(7), 412-25. DOI: 10.1038/nrgastro.2016.85

Mofidi, F., Poustchi, H., Yari, Z., Nourinayyer, B., Merat, S., Sharafkhah, M. … Hekmatdoost A.(2017). Synbiotic supplementation in lean patients with non-alcoholic fatty liver disease: a pilot, randomised, double-blind, placebo-controlled, clinical trial. Br J Nutr, 117 (5), 662-668. DOI: 10.1017/S0007114517000204

Parnell, J.A, Raman, M., Rioux, K.P., Reimer, R.A. (2012). The potential role of prebiotic fibre for treatment and management of non-alcoholic fatty liver disease and associated obesity and insulin resistance. Liver Int, 32(5):701-11. DOI: 10.1111/j.1478-3231.2011.02730.x

Sáez-Lara, M.J., Robles-Sanchez, C., Ruiz-Ojeda, F.J., Plaza-Diaz, J., Gil, A. (2016). Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials. Int J Mol Sci, 17 (6).DOI: 10.3390/ijms17060928

Probiotic & Prebiotic: Cardiovascular, Metabolic Syndrome and Weight Support

Delzenne, N.M., Neyrinck, A.M., Cani, P.D. (2013). Gut microbiota and metabolic disorders: How prebiotic can work? Br J Nutr, 109, 2:S81-5. DOI: 10.1017/S0007114512004047

Delzenne, N.M., Neyrinck, A.M., Bäckhed, F., & Cani, P.D. (2011). Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat rev endocrinol, 7(11), 639-46. DOI: 10.1038/nrendo.2011.126

Delzenne, N.M., Neyrinck, A.M., Cani, P.D. (2011).Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microb Cell Fact, 10 Suppl 1:S10.DOI:10.1186/1475-2859-10-S1-S10

Delzenne, N.M., Cani, P.D. (2011). Interaction between obesity and the gut microbiota: relevance in nutrition. Annu Rev Nutr, 31, 15-31 . DOI:10.1146/annurev-nutr-072610-145146

DiRienzo D.B. (2014). Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets. Nutr Rev, 72(1), 18-29. DOI: 10.1111/nure.12084

Eslamparast, T., Zamani, F., Hekmatdoost, A., Sharafkhah, M., Eghtesad, S., Malekzadeh, R., Poustchi, H.(2014). Effects of synbiotic supplementation on insulin resistance in subjects with the metabolic syndrome: a randomised, double-blind, placebo-controlled pilot study. Br J Nutr, 112(3), 438-45.DOI10.1017/S0007114514000919

Fukushima, M., Yamada, A., Endo, T., Nakano, M. (1999). Effects of a mixture of organisms, Lactobacillus acidophilus or Streptococcus faecalis on delta6-desaturase activity in the livers of rats fed a fat- and cholesterol-enriched diet. Nutrition, 15(5), 373-8. Abstract

Geurts, L., Neyrinck, A.M., Delzenne, N.M., Knauf, C., Cani, P.D. (2014). Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics. Benef Microbes, 5(1), 3-17. DOI: 10.3920/BM2012.0065

Huang, Y., Wang, X., Wang, J., Wu, F., Sui, Y., Yang, L., Wang, Z. (2013). Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity. J Dairy Sci, 96(5), 2746-53.DOI: 10.3168/jds.2012-6123

Kassaian, N., Aminorroaya, A., Feizi, A., Jafari, P., Amini, M. (2017). The effects of probiotic and synbiotic supplementation on metabolic syndrome indices in adults at risk of type 2 diabetes: study protocol for a randomized controlled trial. Trial, 18(1), 148. DOI: 10.1186/s13063-017-1885-8

Kumar, M., Nagpal, R., Kumar, R., Hemalatha, R., Verma, V., Kumar, A… Jain, S. (2012). Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. Exp Diabetes Res, 2012, 902917. DOI: 10.1155/2012/902917

Liong, M.T., Dunshea, F.R., Shah, N.P. (2007). Effects of a synbiotic containing Lactobacillus acidophilus ATCC 4962 on plasma lipid profiles and morphology of erythrocytes in hypercholesterolaemic pigs on high- and low-fat diets. Br J Nutr, 98 (4), 736-44. DOI: 10.1017/S0007114507747803

Nguyen, T.D., Kang, J.H., Lee, M.S. (2007). Characterization of Lactobacillus plantarum PH04, a potential probiotic bacterium with cholesterol-lowering effects. Int J Food Microbiol, 113(3), 358-61. DOI: 10.1016/j.ijfoodmicro.2006.08.015

Ooi, L.G. & Liong, M.T. (2010). Cholesterol-Lowering Effects of Probiotics and Prebiotics: A Review of in Vivo an in Vitro Findings. Int J Mol Sci, 11(6), 2499-2522. DOI: 10.3390/ijms11062499

Roberfroid, M.B. (2000). Prebiotics and probiotics: are they functional foods? Am J Clin Nutr, 71 (6), 1682S-7S; discussion 1688S-90S. Article

Sáez-Lara, M.J., Robles-Sanchez, C., Ruiz-Ojeda, F.J., Plaza-Diaz, J., Gil, A.(2016). Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials. Int J Mol Sci, 17(6).DOI: 10.3390/ijms17060928

Saini, R., Saini, S., & Sharma, S. (2010). Potential of probiotics in controlling cardiovascular diseases. J. Cardiovasc Dis Res,1(4), 213-214. DOI: 10.4103/0975-3583.74267

Sanz Y, Santacruz A, Gauffin P.(2010). Gut microbiota in obesity and metabolic disorders. Proc Nutr Soc, 69(3), 434-41. DOI: 10.1017/S0029665110001813

Serino, M., Blasco-Baque, V., Nicolas, S., & Burcelin, R. (2014). Far from the Eyes, Close to the Heart: Dysbiosis of Gut Microbiota and Cardiovasuclar Consequences. Curr Cardiol Rep, 16(11), 540. DOI: 10.1007/s11886-014-0540-1

Shen, J., Obin, M.S., Zhao, L.(2013). The gut microbiota, obesity and insulin resistance. Mol Aspects Med, 34 (1):39-58.DOI: 10.1016/j.mam.2012.11.001

Shimizu, M., Hashiguchi, M., Shiga, T., Tamura, H.O., Mochizuki, M. (2015). Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals. PLoS One, 10(10), e0139795. DOI: 10.1371/journal.pone.0139795

Wang, J., Zhang, H., Chen, X., Mengheblige, Bao, Q. (2012). Selection of potential probiotic lactobacilli for cholesterol-lowering properties and their effect on cholesterol metabolism in rats fed a high-lipid diet.J Dairy Sci, 95(4), 1645-54. DOI: 10.3168/jds.2011-4768

Xie, N., Cui, Y., Yin, Y.N., Zhao, X., Yang, J.W., Wang, Z.G… Liu, X.W. (2011). Effects of two Lactobacillus strains on lipid metabolism and intestinal microflora in rats fed a high-cholesterol diet. BMC Complement Altern Med, 11:53. DOI: 10.3168/jds.2011-4768

Inulin (Chicory Root) Prebiotic for Cardiovascular Support

Causey, J.L., Feirtag, J.M.5, Gallaher, D.D., Tungland, B.C., Slavin, J.L. (2000). Effects of Dietary Inulin on Serum Lipids, Blood Glucose and the Gastrointestinal Environment in Hypercholesterolemic Men. Nutr Res, 20, 191–201. https://doi.org/10.1016/S0271-5317(99)00152-9

Davidson, M.H., & Maki, K.C. (1999). Effects of dietary inulin on serum lipids. J Nutr, 129(7), 1474S-7S. Abstract

Dehghan, P., Pourghassem, G.B, & Asgharijafarabadi, M. (2013). Effects of high performance inulin supplementation on glycemic status and lipid profile in women with type 2 diabetes: a randomized, placebo-controlled clinical trial. Health Promot Perspect, 3(1), 55-63. DOI: 10.5681/hpp.2013.007

Letexier D, Diraison F, Beylot M. (2017). Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans. Am J Clin Nutr, 77(3), 559-64. Article

Roberfroid, M., Gibson, G.R., Hoyles, L., McCartney, A.L., Rastall, R., Rowland, I…. Meheust, A. (2010). Prebiotic effects: metabolic and health benefits. Br J Nutr, 104, 2, S1-63. DOI: 10.1017/S0007114510003363

Robertfroid, M.B. (1999). Concepts in functional foods: the case of inulin and oligofructose. The Journal of Nutrition, 129(7), 1398-1401. Abstract

Slavin, J. (2013). Fiber and prebiotics: mechanism and health benefits.Nutrients, 5(4), 1417-1435. DOI: 10.3390/nu5041417

Red Beetroot: Cardiovascular support

Clifford, T., Howatson, G., West, D.J., & Stevenson, E.J. (2015. The potential benefits of red beetroot supplementation in health and disease.Nutrients, 7(4), 2801-22. DOI: 10.3390/nu7042801

Coggan, A.R., Leibowitz, J.L., Spearie, C.A., Kadkhodayan, A., Thomas, D.P., Ramamurhy, S., … Peterson, L.R. (2015). Acute dietary nitrate intake improves muscle contractile function in patients with heart failure. Circulation: Heart Failure, 8, 914-920. DOI: 10.1161/CIRCHEARTFAILURE.115.002141

Coles, L.T., & Cliffton, P.M. (2012). Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial. Nutr J., 11, 106. DOI: 10.1186/1475-2891-11-106 .

Eggenbeen, J., Kim-Shapiro, D.B., Haykowsky, M., Morgan, T.M., Basu, S., Brubaker, P., … Kitzman, D.W. (2016). One week of daily dosing with beetroot juice improves submaximal endurance and blood pressure in older patients with heart failure and preserved ejection fraction. JACC Heart Fail, 4(6), 428-37. DOI: 10.1016/j.jchf.2015.12.013

Gilchrist, M., Winyard, P.G., Fulford, J., Anning, C., Shore, A.C., Benjamin, N. (2014). Dietary nitrate supplementation improves reaction time in type 2 diabetes: development and application of a novel nitrate-depleted beetroot juice placebo. Nitric Oxide, 40, 67-74. DOI: 10.1016/j.niox.2014.05.003

Hobbs, D.A., George, T.W., Lovegrove, J.A. (2013). The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies. Nutr Res Rev , 26(2), 210-22. DOI: 10.1017/S0954422413000188

Jajja, A., Sutyarjoko, A., Lara, J., Rennie, K., Brandt, K., Qadir, O., Siervo, M. (2014). Beetroot supplementation lowers daily systolic blood pressure in older, overweight subjects. Nutr Res. 34(10), 868-75. DOI: 10.1016/j.nutres.2014.09.007

Lara, J., Ashor, A.W., Oggioni, C., Ahluwalia, A., Mathers, J.C., Siervo, M. (2016). Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis. Eur J Nutr, 55(2):451-459. DOI: 10.1007/s00394-015-0872-7

Kapil, V., Weitzberg, E., Lundberg, J.O., Ahluwalia, A. (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health. Nitric Oxide, 38, 45-57. DOI: 10.1016/j.niox.2014.03.162

Ninfali P, Angelino D. (2013). Nutritional and functional potential of Beta vulgaris cicla and rubra. Fitoterapia, 89, 188-99. DOI: 10.1016/j.fitote.2013.06.004

Presley, T.D., Morgan, A.R., Bechtold, E., Clodfelter, W., Dove, R.W., Jennings, J.M. …Miller, G.D. (2011). Acute effect of a high nitrate diet on brain perfusion in older adults. Nitric Oxide, 24 (1), 34-42. DOI: 10.1016/j.niox.2010.10.002

Siervo, M., Lara, J., Ogbonmwan, I., Mathers, J.C. (2013). Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr, 143(6), 818-26.DOI: 10.3945/jn.112.170233

Webb, A.J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S.…. Ahluwalia, A. (2008). Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension, 51(3), 784-90. DOI: 10.1161/HYPERTENSIONAHA.107.103523

Wootton-Beard, P.C., Brandt, K., Fell, D., Warner, S., Ryan, L. (2014). Effects of a beetroot juice with high neobetanin content on the early-phase insulin response in healthy volunteers. J Nutr Sci, 3:e9. DOI: 10.1017/jns.2014.7

Beetroot and Liver Support

Lee, C.H., Wettasinghe, M., Bolling, B.W., Ji, L.L., Parkin, K.L. (2005). Betalains, phase II enzyme-inducing components from red beetroot (Beta vulgaris L.) extracts. Nutr Cancer, 53(1), 91-103. DOI: 10.1207/s15327914nc5301_11

Krajka-Kuźniak, V., Paluszczak, J., Szaefer, H., & Baer-Dubowska, W. (2013). Betanin, a beetroot component, induces nuclear factor erythroid-2-related factor 2-mediated expression of detoxifying/antioxidant enzymes in human liver cell lines. British Journal of Nutrition, 110(12), 2138-2149. DOI: https://doi.org/10.1017/S0007114513001645

Krajka-Kuźniak, V., Szaefer, H., Ignatowicz, E., Adamska, T., & Baer-Dubowska, W. (2012). Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats. Food and chemical toxicology, 50(6), 2027-2033. https://doi.org/10.1016/j.fct.2012.03.062

Szaefer, H., Krajka Kuźniak, V., Ignatowicz, E., Adamska, T., & Baer‐Dubowska, W. (2014). Evaluation of the Effect of Beetroot Juice on DMBA‐induced Damage in Liver and Mammary Gland of Female Sprague–Dawley Rats. Phytotherapy Research, 28(1), 55-61. DOI: 10.1002/ptr.4951

Vulić J.J., Ćebović T.N., Čanadanović-Brunet J.M., Ćetković G.S., Čanadanović V.M., Djilas S.M., Tumbas Šaponjac V.T. In vivo and in vitro antioxidant effects of beetroot pomace extracts. J. Funct. Foods. 2014;6:168–175. https://doi.org/10.1016/j.jff.2013.10.003 .

Beetroot: Antioxidant, Anti-inflammatory, Antimicrobial Support

Čanadanović-Brunet, J. M., Savatović, S. S., Ćetković, G. S., Vulić, J. J., Djilas, S. M., Markov, S. L., & Cvetković, D. D. (2011). Antioxidant and antimicrobial activities of beet root pomace extracts. Czech Journal of Food Sciences, 29(6), 575-585. Abstract

Clifford, T., Howatson, G., West, D.J., Stevenson, E.J. (2015). The potential benefits of red beetroot supplementation in health and disease.Nutrients,7(4):2801-22. DOI: 10.3390/nu7042801

Georgiev, V.G., Weber, J., Kneschke, E.M., Denev, P.N., Bley, T., Pavlov, A.I. (2010). Antioxidant activity and phenolic content of betalain extracts from intact plants and hairy root cultures of the red beetroot Beta vulgaris cv. Detroit dark red.

Plant Foods Hum Nutr, 65 (2):105-11. DOI: 10.1007/s11130-010-0156-6

Kujala, T. S., Vienola, M. S., Klika, K. D., Loponen, J. M., & Pihlaja, K. (2002). Betalain and phenolic compositions of four beetroot (Beta vulgaris) cultivars. European Food Research and Technology, 214(6), 505-510. DOI: 10.1007/s00217-001-0478-6

Wootton-Beard P.C., & Ryan L. A beetroot juice shot is a significant and convenient source of bioaccessible antioxidants. (2011). J. Funct. Foods, 3, 329–334. https://doi.org/10.1016/j.jff.2011.05.007

Zielińska-Przyjemska M, Olejnik A, Dobrowolska-Zachwieja A, Grajek W. (2009). In vitro effects of beetroot juice and chips on oxidative metabolism and apoptosis in neutrophils from obese individuals. Phytother Res, 23(1), 49-55. DOI: 10.1002/ptr.2535

Probiotic and Inulin: Leaky Gut, Microbiome Health, and Metabolic Syndrome

Al Khodor, S., Reichert, B., Shatat, I.F.(2017). The Microbiome and Blood Pressure: Can Microbes Regulate Our Blood Pressure? Front Pediatr, 5, 138. DOI: 10.3389/fped.2017.00138

Cani, P.D., Delzenne, N.M. (2011).The gut microbiome as therapeutic target. Pharmacol Ther, 130 (2), 202-12.DOI: 10.1016/j.pharmthera.2011.01.012

Cani, P.D., Pssemiers, S., Van de Wiele, T., Guiot, Y., Everad, A., Rottier, O…. Delzenne, N.M. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut, 58(8), 1091-1103. DOI: 10.1136/gut.2008.165886

Cani, P.D., Bibiloni, R., Knauf, C., waget, A., Neyrinck, A.M., Delzenne, N.M., Burcelin, R. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice. Diabetes, 57, 1470-8. DOI: 10.2337/db07-1403

Cani, P.D., Amar, J., Iglesias, M.A., Poggi, M., Knauf, C., Bastelica, D. … Burelini, R. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 56, 1761-72. DOI: 10.2337/db06-1491

Cani, P.D., Neyrinck, A.M., Fava, F., Knauf, C., Burcelin, R.G., Tuohy, K.M. … Delzenne, N.M. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia, 50, 2374-83. DOI: 10.1007/s00125-007-0791-0

Delzenne, N.M., Neyrinck, A.M., Backhed, F., Cani P.D. (2011). Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat Rev Endocrinol, 7(11), 639-46. DOI: 10.1038/nrendo.2011.126

Delzenne, N.M., Neyrinck, A.M., Cani, P.D.(2011). Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microb Cell Fact, 10 Suppl 1, S10. DOI: 10.1186/1475-2859-10-S1-S10

Eid, H.M., Wright, M.L., Anil Kumar, N.V., Qawasmeh, A., Hassan, S.T.S., Mocan, A. … Haddad, P.S. (2017).Significance of Microbiota in Obesity and Metabolic Diseases and the Modulatory Potential by Medicinal Plant and Food Ingredients. Front Pharmacol, 8, 387. DOI: 10.3389/fphar.2017.00387

Frazier TH, DiBaise JK, McClain CJ. (2011).Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury. JPEN J Parenter Enteral Nutr, 35(5 Suppl), 14S-20S. DOI: 10.1177/0148607111413772

Fiber for Regularity*

Clemens, R., Kranz, S., Mobley, A.R., Nicklas, T.A., Raimondi, M.P., Rodriguez, J.C., … Warshaw, H. (2012). Filling American’s fiber intake gap: Summary of roundtable to probe realistic solutions with a focus on grain-based foods. J Nutr, 142(7), 1390-1401. DOI: 10.3945/jn.112.160176

Cooper, D.N., Kable, M.E., Marco, M.L., De Leon, A., Rust, B., Baker, J.E. … Keim, N.L. (2017). The Effects of Moderate Whole Grain Consumption on Fasting Glucose and Lipids, Gastrointestinal Symptoms, and Microbiota.Nutrients, 9(2). ). DOI: 10.3390/nu9020173

Mobley, A.R., Jones, J.M., Rodriguez, J., Slavin, J., & Zelman, K.M. (2014). Identifying practical solutions to meet American’s fiber needs: Proceedings from the Food & Fiber Summit. Nutrients, 8(7), 2540-51. DOI: 10.3390/nu6072540

Kranz, S., Dodd, K.W., Juan, W.Y., Johnson, L.K., Jahns, L. (2017). Whole Grains Contribute Only a Small Proportion of Dietary Fiber to the U.S. Diet. Nutrients, 9(2).DOI: 10.3390/nu9020153

Schmier, J.K., Miller, P.E., Levine, J.A., Perez, V., Maki, K.C., Rains, T.M., … Alexander, D.D. (2014). Cost savings reduced constipation rates attributed to increased dietary fiber intakes: A decision-analytic model. BMC Public Health, 14-374. DOI: 10.1186/1471-2458-14-374

Seal, C.J., Brownlee, I.A.(2015). Whole-grain foods and chronic disease: evidence from epidemiological and intervention studies. Proc Nutr Soc, 74(3), 313-9. DOI: 10.1017/S0029665115002104

*For more data on GI regularity see the research for Be Regular

B-Glucan: Support During Oncological treatment

Choromanska, A., Kulbacka, J., Rembialkowska, N., Pilat, J., Oledzki, R., Harasym, J., Saczko, J. (2015). Anticancer properties of low molecular weight oat beta-glucan – An in vitro study. Int J Biol Macromol, 80, 23-8. DOI: 10.1016/j.ijbiomac.2015.05.035

Vetvicka, V. (2013). Synthetic oligossacharides: clinical application in cancer therapy. Anticancer Agents Md Chem, 13(5), 720-4. Abstract

Yoon, T.J., Koppula, S., & Lee, K.H. (2013). The effects of B-glucans on cancer metastasis. Anticancer Agents Med Chem, 13(5), 699-708. Abstract

Red beetroot: Support During Oncological treatment

Das, S., Fillippone, S.M., Williams, D.S., Das, A., Kukreja, R.C. (2016). Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells. Mol Cell Biochem, 421(1-2), 89-101. DOI: 10.1007/s11010-016-2789-8

Das, S., Williams, D.S., Das, A., Kukreja, R.C. (2013). Beet root juice promotes apoptosis in oncogenic MDA-MB-231 cells while protecting cardiomyocytes under doxorubicin treatment. J. Exp. Second. Sci, 2, 1–6. Abstract

Kapadia, G.J., Rao, G.S., Ramachandran, C., Iida, A., Suzuki, N., & Tokuda, H. (2013). Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines. J Complement Integr Med., 1. DOI: 10.1515/jcim-2013-0007

Kapadia, G.J., Azuine, M.A., Rao, G.S, Arai, T., Lida, A., & Tokuda, H. (2011), Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines. Anticancer Agents Med Chem, 11(3), 280-4. Abstract

Kapadia, G. J., Azuine, M. A., Sridhar, R., Okuda, Y., Tsuruta, A., Ichiishi, E., ... & Tokuda, H. (2003). Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot. Pharmacological Research, 47(2), 141-148. https://doi.org/10.1016/S1043-6618(02)00285-2

Kapadia, G.J., Tokuda, H., Konoshima, T., & Nishino, H. (1996). Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract. Cancer Lett, 100(1-2), 211-4. Abstract

Ninfali P, Antonini E, Frati A, Scarpa ES.(2017). C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review.Phytother Res, 31(6), 871-884. DOI: 10.1002/ptr.5819

Ninfali, P., & Angelino, D. (2013). Nutritional and functional potential of Beta vulgaris cicla and rubra. Fitoterapia, 89, 188-199. https://doi.org/10.1016/j.fitote.2013.06.004

Nowacki, L., Vigneron, P., Rotellini, L., Cazzola, H., Merlier, F., Prost, E. … Vayssade, M.(2015). Betanin-Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells. Phytother Res, 29(12), 1964-73. DOI: 10.1002/ptr.5491

Zielińska-Przyjemska, M., Olejnik, A., Dobrowolska-Zachwieja, A., Łuczak, M., Baer-Dubowska, W.(2016). DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin. Postepy Hig Med Dosw (Online), 70, 265-71. Abstract

Beetroot: Energy & Weight Management

Bailey, S.J., Winyard, P., Vanhatalo, A., Blackwell, J.R., Dimenna, F.J., Wilkerson, D.P. … Jones, A.M. (1985; 2009). Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol, 107(4), 1144-55. DOI: 10.1152/japplphysiol.00722.2009

Beals, J.W., Binns, S.E., Davis, J.L., Giordano, G.R., Klochak, A.L., Paris, H.L. … Bell, C.(2017). Concurrent Beet Juice and Carbohydrate Ingestion: Influence on Glucose Tolerance in Obese and Nonobese Adults. J Nutr Metab, 2017:6436783. https://doi.org/10.1155/2017/6436783

Clifford, T., Howatson, G., West, D.J., Stevenson, E.J. (2017). Beetroot Juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. DOI: 10.1139/apnm-2017-0238

Clifford, T., Constantinou, C.M., Keane, K.M., West, D.J., Howatson, G., Stevenson, E.J. (2017). The plasma bioavailability of nitrate and betanin from Beta vulgaris rubra in humans. Eur J Nutr, 56(3), 1245-54. DOI: 10.1007/s00394-016-1173-5

Clifford T, Berntzen B, Davison GW, West DJ, Howatson G, Stevenson EJ. (2016). Effects of Beetroot Juice on Recovery of Muscle Function and Performance between Bouts of Repeated Sprint Exercise.Nutrients, 8(8). DOI: 10.3390/nu8080506

Domínguez, R., Cuenca, E., Maté-Muñoz, J.L., García-Fernández, P., Serra-Paya, N., Estevan, M.C., Herreros, P.V., Garnacho-Castaño, M.V. (2017). Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review. Nutrients, 9(1).DOI: 10.1016/j.jand.2011.12.002

Murphy, M., Eliot, K., Heuertz, R.M., Weiss, E. (2012). Whole beetroot consumption acutely improves running performance. J Acad Nutr Diet , 112(4), 548-52. DOI: 10.1016/j.jand.2011.12.002

Vanhatalo, A., Bailey, S.J., Blackwell, J.R., DiMenna, F.J., Pavey, T.G., Wilkerson, D.P. … Jones, A.M. (2010). Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol, 299(4), R1121-31. DOI: 10.1152/ajpregu.00206.2010

Zielińska-Przyjemska, M., Olejnik, A., Dobrowolska-Zachwieja, A., Grajek, W. (2009). In vitro effects of beetroot juice and chips on oxidative metabolism and apoptosis in neutrophils from obese individuals. Phytother Res,23(1), 49-55. DOI: 10.1002/ptr.2535

Beta Glucan Synbiotic: High Potency Cardiovascular and Metabolic Support

A Proprietary blend- 13grams (2 tablespoons)

Prebiotic and Phytonutrients- Oat Bran (10% Beta Glucan fiber 850mg), Organic Red Beetroot, and Inulin from Organic Chicory Root. (99.98% gluten free)

BioImmersion Probiotic Master Blend – Probiotics- Lactobacillus acidophilus, Lactobacillus casei rhamnosus, Lactobacillus plantarum, Streptococcus thermophilus, Bifidobacterium longum; Supernatant- probiotic metabolites, and ORNs.  65 billion CFU.

Nutrients:

Calories                                  45
Calories from fat                     5
Total fat                                  1g
Total carbohydrate                 8g
Dietary fiber                           2g
Soluble fiber       less than     1g
Protein                                   2g
Iron                                  .70mg

Container:  300 grams

BETA GLUCAN SYNBIOTIC—The Beta Glucan is designed as a daily food for heart health. The powerful probiotic mix together with the beta glucans offers one of the best combinations for a healthy microbiome (GI Tract).*

Heart health: Take 2 tablespoons a day to lower cholesterol, mix with water or diluted juice. The Beta Glucan has the American Heart Association seal of approval.*

Metabolic Syndrome:  Includes issues related to the heart, obesity, diabetes, congestive liver, and cancer. The American Heart Association suggests 3.5 grams of oat beta glucans (2 heaping tablespoons) a day as a measure to prevent and reverse metabolic syndrome.*

Leaky gut & endotoxemia: The probiotic mix produces short chained fatty acids which in turn tighten the junction (where cells join other cells on the gut wall), preventing large molecules from leaking into the systemic circulation, leading to endotoxemia. Take 1 teaspoon to 1 tablespoon a day.*

Protection: The probiotics mix supports detox and help protect against foodborne pathogens (clostridium, E. coli, salmonella, campylobacter, etc.), Foodborne carcinogens (heterocyclic amines from grilled red meat, nitrosamines from sausage and cured meats, etc.), mycotoxins (mold toxins), and heavy metals. Take 1 teaspoon to 1 tablespoon a day.*

Weight-Loss & Energy: Take 1-2 caps Weight-Less 15-20 minutes before meals. Add 1 cap Energy (Ultra Minerals) and Fructo Borate to boost strength and endurance.*

Our favorite: Create a smoothie combining Beta Glucan with Be Regular for a more powerful fiber and nutrient boost and as a meal replacement with diluted juice, berries, Fruits (bananas), flax seeds and plant-based protein powder if needed. At times, for variety, add raw cocoa, No 7 Systemic Booster, and greens.*