High ORAC Synbiotic

Probiotic-  Certified strains of Bifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus and Streptococcus thermophilus (30 billion CFU per gram); Prebiotic- Inulin from chicory Root; Supernatant- probiotic metabolites, and ORNs (Oligoribonucleotides.  Also called MicroRNAs); Phytonutrients- Grape Seed Extract, Wild Blueberry, Quercetin, Resveratrol, Wild Bilberry, Cranberry, Tart Cherry, Prune, Raspberry Seed, Strawberry (Total ORAC assay 40,000 per capsule)

Advanced freeze-drying technology with 60 caps/bottle. 500 mg/ cap.

No excipients.

• Combination of Green Technology for highest phytonutrient potential and Microbiome Technology for pure cultures of pedigreed strains of standardized referenced material with Original molecular identity confirmed routinely by DNA sequencing.
• Berry extracts and Fruit- 250mg of pure freeze dried Wild Blueberry, Grape Seed Extract, Raspberry Seed, Wild Bilberry, Cranberry, Tart Cherry, Prune, Strawberry, Quercetin, and Resveratrol.
• 250mg of inulin from chicory fiber.
• 30 billion of the Super Blend  of certified strains of Bifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus and Streptococcus thermophilus.
• The High ORAC Synbiotic is designed for calming and rejuvenating inflammatory conditions in the GI tract. In particular, it was formulated to offer a perfect first step after antibiotic therapy.
• A new generation Synbiotic formula: The selected probiotic organisms are shown in research to be excellent colonizers of the GI Tract. They inhibit pathogens, strengthen the mucus membrane, protect from yeast and other pathogens, and create a balanced environment that bolster the health of the microbiome (GI Tract). Phenols are shown in research to have powerful anti-microbial and anti-inflammatory properties. With the extensive variety of our potent berries and fruit concentrates, the formula is brought up to a new level of regenerating the GI Tract. Their phenolic profile and fibers work synergistically with probiotic organisms to form the next generation of symbiotic formulas. The High ORAC can be utilized as a comprehensive post antibiotic care, and as a daily booster.
• The extensive variety of berries, fruits, and fiber from organic chicory root aligns with the recommended anti-oxidant score of 9-12 fruits and vegetables, with the phytonutrients and high ORAC values.
• Potent antioxidant with Total ORAC of 40,000 units per capsule (as compared to: 5-9 fruits and vegetables a day provide 1800 to 2500 ORAC units).
• Super Blend Probiotics with their supernatant and microRNA selected to protect, counteract and neutralize dietary toxins, mutagens, carcinogens and infectious organisms.
• Detoxifies dietary mycotoxins, enterotoxins, exotoxins and carcinogens.
• Reduces inflammation systemically and throughout the gastrointestinal system: Original strains in conjunction with Wild Blueberry, Wild Bilberry, Grape Seed Extract, Raspberry Seed Extract, Tart Cherry, Prune Quercetin, Resveratrol,.
  • Preservation of stem cells.
  • Cardiovascular health
• Regeneration of the enteric nervous system: Wild Blueberry, Wild Bilberry.
• Broad spectrum antimicrobial: Original strains in conjunction with Raspberry Seed extract, Wild Blueberry Extract, Grape Seed extract, Cranberry.
• Vision: Wild Blueberry, Wild Bilberry extt
• No fillers, flowing agents or excipients of any kind.
• Read monograph in the web library.

FOOD SCIENCE: THE APPLICATION AND USE OF:

PROBIOTIC SUPER BLEND: L. ACIDOPHILUS, B. LONGUM, L. CASEI, L. BULGARICUS, AND STREPTOCOCCUS THERMOPHILUS, SUPERNATANT, AND ORNS (MICRORNA). 30 BILLON CFU.

PHYTONUTRIENTS: GRAPE SEED EXTRACT, WILD BLUEBERRY, QUERCETIN, RESVERATROL, WILD BILBERRY, CRANBERRY, TART CHERRY, PRUNE, RASPBERRY SEED, STRAWBERRY, AND INULIN FROM CHICORY ROOT.*

HIGH ACTIVE POLYPHENOL: TOTAL ORAC 40,000PPM.

Post Antibiotic Care

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Holscher, H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes, 8(2), 172-184. Article

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Kasubuchi, M., Hasegawa, S., Hiramatsu, T., Ichimura, A., & Kimura, I. (2015). Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation. Nutrients, 7(4), 2839-2849. Article

Kawabata, K., Yoshioka, Y., & Terao, J. (2019). Role of intestinal microbiota in the bioavailability and physiological functions of dietary polyphenols. Molecules, 24(2), 370. Article

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Kumar, S., Bansal, A., Chakrabarti, A., & Singhi, S. (2013). Evaluation of efficacy of probiotics in prevention of Candida colonization in a PICU—a randomized controlled trial. Critical care medicine, 41(2), 565-572. Article

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Ling, X., Linglong, P., Weixia, D., & Hong, W. (2016). Protective Effects of Bifidobacterium on Intestinal Barrier Function in LPS-Induced Enterocyte Barrier Injury of Caco-2 Monolayers and in a Rat NEC Model. PloS one, 11(8), e0161635. Article

Liévin-Le Moal, V., & Servin, A. L. (2014). Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents. Clinical microbiology reviews, 27(2), 167-199. Article

Maguire, M., & Maguire, G. (2019). Gut dysbiosis, leaky gut, and intestinal epithelial proliferation in neurological disorders: towards the development of a new therapeutic using amino acids, prebiotics, probiotics, and postbiotics. Reviews in the Neurosciences, 30(2), 179-201. Article

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McFarland, L. V. (2006). Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. The American journal of gastroenterology, 101(4), 812. Abstract

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Polyphenols: Antimicrobial & Anti-inflammatory

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Mileo, A. M., Nisticò, P., & Miccadei, S. (2019). Polyphenols: Immunomodulatory and Therapeutic Implication in Colorectal Cancer. Frontiers in Immunology, 10. Article

Moco, S., Martin, F. P. J., & Rezzi, S. (2012). Metabolomics view on gut microbiome modulation by polyphenol-rich foods. Journal of proteome research, 11(10), 4781-4790. Abstract 

Nazzaro, F., Fratianni, F., d’Acierno, A., De Feo, V., Ayala-Zavala, F. J., Gomes-Cruz, A., ... & Coppola, R. (2019). Effect of Polyphenols on Microbial Cell-Cell Communications. In Quorum Sensing (pp. 195-223). Academic Press. Chapter8

Nohynek, L. J., Alakomi, H. L., Kähkönen, M. P., Heinonen, M., Helander, I. M., Oksman-Caldentey, K. M., & Puupponen-Pimiä, R. H. (2006). Berry phenolics: antimicrobial properties and mechanisms of action against severe human pathogens. Nutrition and cancer, 54(1), 18-32. Abstract

Patel, K. D., Scarano, F. J., Kondo, M., Hurta, R. A., & Neto, C. C. (2011). Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) selectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans. Journal of agricultural and food chemistry, 59(24), 12864-12873. Abstract

Puupponen‐Pimiä, R., Nohynek, L., Hartmann‐Schmidlin, S., Kähkönen, M., Heinonen, M., Määttä‐Riihinen, K., & Oksman‐Caldentey, K. M. (2005). Berry phenolics selectively inhibit the growth of intestinal pathogens. Journal of applied microbiology, 98(4), 991-1000. Article

Puupponen-Pimia, R., Nohynek, L., Alakomi, H.L., & Oksman-Caldentey, K.M. (2005). The action of berry phenolics against human intestinal pathogens. Biofactors, 23(4), 243-51. Abstract

Puupponen‐Pimiä, R., Nohynek, L., Meier, C., Kähkönen, M., Heinonen, M., Hopia, A., & Oksman‐Caldentey, K. M. (2001). Antimicrobial properties of phenolic compounds from berries. Journal of applied microbiology, 90(4), 494-507. Article

Ozdal, T., Sela, D. A., Xiao, J., Boyacioglu, D., Chen, F., & Capanoglu, E. (2016). The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility. Nutrients, 8(2), 78. Article

Skrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., & Sochor, J. (2015). Bioactive compounds and antioxidant activity in different types of berries. International journal of molecular sciences, 16(10), 24673-24706. Article

Shmuely, H., Ofek, I., Weiss, E. I., Rones, Z., & Houri-Haddad, Y. (2012). Cranberry components for the therapy of infectious disease. Current opinion in biotechnology, 23(2), 148-152. Article

Teodoro, G. R., Ellepola, K., Seneviratne, C. J., & Koga-Ito, C. Y. (2015). Potential use of phenolic acids as anti-Candida agents: a review. Frontiers in microbiology, 6, 1420. Article

Tomás-Barberán FA, Selma MV, Espín JC. (2016). Interactions of gut microbiota with dietary polyphenols and consequences to human health. Curr Opin Clin Nutr Metab Care, 19(6), 471-476. Abstract

Valdez, J. C., & Bolling, B. W. (2019). Anthocyanins and intestinal barrier function: a review. Journal of Food Bioactives, 5, 18-30. Article

Valdés, L., Cuervo, A., Salazar, N., Ruas-Madiedo, P., Gueimonde, M., & González, S. (2015). The relationship between phenolic compounds from diet and microbiota: impact on human health. Food & function, 6(8), 2424-2439. Abstract

Vendrame, S., & Klimis-Zacas, D. (2015). Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-κB and mitogen-activated protein kinase signaling cascades. Nutr Rev, 73(6), 348-58. Abstract

Berries and Metabolic Syndrome: Heart, Obesity, and Cancer Support

Baby, B., Antony, P., Al Halabi, W., Al Homedi, Z., & Vijayan, R. (2016). Structural insights into the polypharmacological activity of quercetin on serine/threonine kinases. Drug design, development and therapy, 10, 3109. Article

Basu, A., & Lyons, T.J. (2012). Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives. J Agric Food Chem, 60: 5687-92. Abstract

Basu, A., Rhone, M., & Lyons, T.J. (2010) Berries: emerging impact on cardiovascular health. Nutr Rev, 68,168-177. Article

Burton-Freeman, B.M., Sandhu, A.K., & Edirisinge, I. (2016). Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links. Adv Nutr, 7(1):44-65. Article

Casto, B. C., Knobloch, T. J., Galioto, R. L., Yu, Z., Accurso, B. T., & Warner, B. M. (2013). Chemoprevention of oral cancer by lyophilized strawberries. Anticancer research, 33(11), 4757-4766. Abstract

Edirisinghe, I., Burton-Freeman, B., & Tissa, Kappagoda, C. (2008). Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clin Sci (Lond), 114(4), 331-7. Article

Edirisinghe, I., Burton-Freeman, B., Varelis, P., & Kappagoda, T. (2008). Strawberry extract caused endothelium-dependent relaxation through the activation of PI3 kinase/Akt. J Agric Food Chem, 56 (20), 9383-90. Article

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Edwards, C. A., Havlik, J., Cong, W., Mullen, W., Preston, T., Morrison, D. J., & Combet, E. (2017). Polyphenols and health: Interactions between fibre, plant polyphenols and the gut microbiota. Nutrition bulletin, 42(4), 356-360. Article

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* See Supernatant research & description tabs for more on the Probiotic Super Blend.

High ORAC Synbiotic: Post Antibiotic Care

A Proprietary blend of:                                        500mg

Phytonutrients- Grape Seed Extract, Wild Blueberry, Quercetin, Resveratrol, Wild Bilberry, Cranberry, Tart Cherry, Prune, Raspberry Seed, Strawberry, and Inulin from Chicory Root. ORAC 40,000.

BioImmersion Probiotic Super Blend – Probiotics- Bifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus and streptococcus thermophilus; Prebiotic- Inulin from chicory Root; Supernatant- probiotic metabolites, and ORNs. 30 billion CFU.

Capsule- Cellulose & Water

HIGH ORAC SYNBIOTIC—- The High ORAC is designed as a powerful post antibiotic care, with 40,000ppm Total ORAC.*

Post Antibiotic Care: The High ORAC is the most powerful anti-oxidant product on the market, with 40,000ppm of total ORAC, and a broad-spectrum plant polyphenol that boosts nitric oxide levels in the blood, stimulates antioxidant activity, and supports efficient cellular oxygen consumption. The mix restores and renews the GI Tract, re-colonizes the gut with strong organisms, and re-energizes every cell in the body. Take 1-2 capsules daily.*

Yeast infection: Antibiotics often unbalance the microbiome (GI Tract) resulting in overgrowth of yeast in the gut and vagina. Plant extracts have antimicrobial properties, and together with the probiotic, reduce pathogenic populations. Take 1-2 caps High ORAC. Add Garlic (2-3 capsules daily) for its antimicrobial ability for 7-10 days.*

Sports, exercise, and reduction of oxidation: The High ORAC’s total 40,000ppm Oxygen Radical Absorbent Capacity means that it has a high ability to neutralize free radicals in the body. Take 1 capsules before exercise to reduce muscle soreness. Add Energy (1-2 caps) for added strength.*

Our favorite: The High ORAC has such a calmative effect that even a very sensitive gut (intestines and colon) can benefit and thrive. The intense total ORAC has a powerful anti-inflammatory quality. For very sensitive guts: Start with 1 capsule every other day and increase to 1 cap a day.*