Blueberry Extract

The most powerful blueberry extract on the market. This 100% North American blueberry has an unusually broad spectrum of anthocyanins. Our advanced extraction process captures a hundred percent of the anthocyanins of the whole berry!


The blueberry extract is known for both health and beauty and is considered to be one of the most effective brain foods for cognition and memory health.

$137.94

Availability: In stock

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Description

Details

Blueberry extract (Vaccinium corymbosum), has a phenolic profile that is truly remarkable and the fact that it perfectly corresponds to the profile of the fresh blueberries is a testament to the richness and purity of the extract. Proprietary extraction process. Advanced freeze-drying technology. No excipients. Each capsule equivalent to 1 1/4 cups of whole blueberry. 60 capsules per bottle. 500 mg vegetarian capsule.

  • Green and Patented Technology for highest phytonutrient potential.
  • The phenolic content/profile of this very special 100% Northern American blueberry cultivar, Vaccinium corymbosum, is truly remarkable.
  • Using leading edge polyphenolic analyses along with new technology to measure the Total ORAC confirms that this blueberry contains a phenolic profile and content that is among the richest of all fruit.
  • Pure blueberry extract, 500mg in a vegetarian capsule.
  • It takes us eighty pounds of these berries to get one pound of the pure purple extract with its rich broad spectrum of different kinds of anthocyanins. Designed for intensive therapeutic purposes.
  • According to Dr. James Joseph, the past Director of Research at Tuft University's USDA Anti-Aging Center, our 500 mg capsule contains three times the daily requirement of the researched amount of blueberry extract to reverse and prevent brain aging, improve short-term memory and improve motor skills.
  • Neuro-regenerative: stimulates nervous tissue regeneration in the brain. Develops new brain cells, improves short-term memory, improves motor skills, amelioration of age-related declines in neural and cognitive function.
  • Potent anti-inflammatory: reduction of NF Kappa beta, Cox-2 and Isoprostane.
  • Preservation of stem cells.
  • Blocks effects of radiation, prevents radiation sickness, anti-angiogenic, protects against the initiation, promotion and progression stages.
  • Potent anti-oxidant: increased ORAC in bloodstream, reduced level of 8-isoprostane in blood and urine and reduced lipid oxidation in vivo.
  • Reduction of age associated lipid peroxidation.
  • Powerful protection from environmental toxins.
  • No fillers, flowing agents or excipients of any kind.
  • Read the Blueberry Extract Monograph in the BioImmersion web library.
Research

Research

Food Science: The Application and Use of Blueberry and Blueberry Extract.

Blueberry and Cognitive Support

Brewer, G.J., Torricelli, J.R., Lindsey, A.L., Kunz, E.Z., Neuman, A., Fisher, D.R., & Joseph, J.A. (2010). Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem, 21, 991-998.

Carey, A.N., Gomes, S.M., & Shukitt-Hale, B. (2014). Blueberry supplementation improves memory in middle-aged mice fed a high-fat diet. J Agric Food Chem, 62, 3972-3978.

Casadesus, G., Shukitt-Hale, B., Stellwagen, H.M., Zhu, X., Lee, H.G., Smith, M.A., Joseph, J.A. (2004). Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci, 7, 309-316.

Chemiack, E.P. (2012). A berry thought-provoking idea: the potential role of plant polyphenols in the treatment of age-related cognitive disorder. Br J Nutr, 108(5), 794-800.

Devore, E.E., Kang, J.H., Breteler, M.M., & Grodstein, F. (2012). Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol, 72(1), 135-43.

Duffy, K.B., Spangler, E.L., Devan, B.D., Guo, Z., Bowker, J.L., Janas, A.M., Hagepanos, A., Minor, R.K., DeCabo, R., Mouton, P.R., Shukitt-Hale, B., Joseph, J.A., Ingram, D.K. (2008). A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging, 29, 1680-1689.

Goyarzu, P., Malin, D.H., Lau, F.C., Taglialatela, G., Moon, W.D., Jennings, R., Moy, E., Moy, D., Lippold, S., Shukitt-Hale, B., Joseph, J.A. (2004). Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged rats. Nutr Neurosci, 7, 75-83.

Joseph, J.A., Shukitt-Hale, B., & Lau, F.C. (2007). Fruit polyphenols and their effects on neuronal signaling and behavior in senescence. Ann NY Acd Sci, 1100, 470-85.

Joseph, J.A., Shukitt-Hale, B., Denisova, N.A., Bielinski, D., Martin, A., McEwen, J.J., & Bickford, P.C. (1999). Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci, 19(18), 8114-21.

Krikorian, R., Shidler, M.D., Nash, T.A., Kalt, W., Vingvist-tymchuk, M.R., Shukitt-Hale, B., Joseph, J.A. (2010).  Blueberry supplementation improves memory in older adults. J. Agric Food Chem, 58, 3996-4000.

Malin, D.H., Lee, D.R., Goyarzum P., Chang, Y.H., Ennis, L.J., Beckett, E., Shukitt-Hale, B., Joseph, J.A. (2011). Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats. Nutrition, 27, 338-342.

Poulose, S.M., carey, A.N., Shukitt-Hale, B. (2012). Improving brain signaling in aging: Could berries be the answer? Expert Rev Neurother, 12(8), 887-9.

Schaffer, S., Eckert, G.P., Schmitt-Schilling, S., & Muller, W.E. (2006). Plant foods and brain aging: a critical appraisal. Forum Nutr, 59, 86-115.

Shukitt-Hale, B., Bielinski, D.F., Lau, F.C., Willis, L.M., Carey, A.N., & Joseph, J.A. (2015). The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. Br J Nutr, 114(10), 1542-9.

Shukitt-Hale, B. (2012).  Blueberries and neuronal aging. Gerontology, 58, 518-523. doi: 10.1159/000341101

Shukitt-Hale, B., Lau, F.C., Joseph, J.A. (2008). Berry fruit supplementation and the aging brain. Journal of Agricultural and Food Chemistry, 56, 636–641.

Willis, L.M., Shukitt-Hale, B., Joseph, J.A. (2009). Recent advances in berry supplementation and age-related cognitive decline. Curr Opin Clin Nutr Metab Care, 12(1), 91-4.

Polyphenols and Neuro-Protective Effect

Esposito, E., Rotilio, D., Di Matteo, V., Di Giulio, C., Cacchio, M., Algeri, S. (2012). A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol Aging, 23, 719-735. 

Galli, R.L., Bielinski, D.F., Szprengiel, A., Shukitt-Hale, B., Joseph, J.A. (2006). Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection. Neurobio Aging, 27, 344-350. 

Gao, X., Cassidy, A., Schwarzschild, M.A., Rimm, E.B., & Ascherio, A. (2012). Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology, 78(15), 1138-45. doi: 10.1212/WNL.0b013e31824f7fc4.

Giacalone, M., Di Sacco, F. Traupe, I., Topini, R., Forfori, F., & Giunta, F. (2011). Antioxidant and neuroprotective properties of blueberry polyphenols: A critical review. Nutr Neurosci, 14(3), 119-25. doi: 10.1179/1476830511Y.0000000007.

Fuentealba, J., Dibarrant, A.J., Fuentes-Fuentes, M.C., Saez-Orellana, F., Qunones, K., Guzman, L., … Aguayo, L.G. (2011). Syaptic failure and adenosine triphosphate imbalance induced by amyloid-β aggregates are prevented by blueberry-enriched polyphenols extracts. J Neurosci Res, 89(9), 1499-508. doi: 10.1002/jnr.22679.

Joseph, J.A., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Moragan, D., & Denisova, N.A. (2013). Blueberry Supplementation Enhances Signaling and Prevents Behavioral Deficits in an Alzheimer Disease Model. Nutritional Neuroscience, 6(3), 153-62. doi.org/10.1080/1028415031000111282

Joseph, J.A., Denisova, N.A., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D. (2003). Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci, 6, 153-162.

Joseph, J.A., Shukitt-Hale, B., Denisova, N.A., Bielinski, D., Martin, A., McEwen, J.J., Bickford, P.C. (1999). Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 19, 8114-8121.

Kolosova, N.G., Shcheglova, T.V., Sergeeva, S.V., Loskutova, L.V. (2006) Long-term antioxidant supplementation attenuates oxidative stress markers and cognitive deficits in senescent-accelerated OXYS rats. Neurobiol Aging, 27, 1289-1297.

Kovacsova, M., Barta, A., Parohova, J., Vrankova, S., Pechanova, O. (2010) Neuroprotective mechanisms of natural polyphenolic compounds. Act Nerv Super Rediviva, 52, 181-186.

Meng, X., Munishkina, L.A., Fink, A.L., Uversky, V.N. (2010). Effects of Various Flavonoids on the α-Synuclein Fibrillation Process. Parkinson Dis., 650794. doi: 10.4061/2010/650794.

Nile, S.H., Park, S.W. (2014). Edible berries: Bioactive components and their effect on human health. Nutrition, 30, 134-144. 

Ono, K., Yoshiike, Y., Takashima, A., Hasegawa, K., Naiki, H., & Ymada, M. (2003). Potent Anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer’s isease. J Neurochem, 87, 172-181.

Pandey, K.B., Rizv,i S.I. (2009). Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev, 2, 270-278.

Schaffer, S., Eckert, G.P., Schmitt-Schillig, S., Müller, W.E. (2006). Plant foods and brain aging: a critical appraisal. Forum Nutr, 59, 86-115. 

Shukitt-Hale, B. (2012). Blueberries and neuronal aging. Gerontology, 58(6), 518-23. doi: 10.1159/000341101.

Shukitt-Hale, B., Lau, F.C., Carey, A.N., Galli, R.L., Spangler, E.L., Ingram, D.K., Joseph, J.A. (2008). Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus. Nutr Neurosci, 11, 172-182.

Shukitt-Hale, B., Carey, A.N., Jenkins, D., Rabin, B.M., Joseph, J.A. (2007). Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging, 28, 1187-1194.

Strathearm, K.D., Yousef, G.G., Grace, M.H., Tambe, M.A., Ferruzzi, M.G., Wu, Q.L., Simon, J.E., Lila, M.A., & Rochet, J.C. (2014). Neuroprotective effects of anthocyanin-and proanthocyanidin-rich extracts in cellular models of Parkinson’s diseases. Brain Res, 1555, 60-77.

Stromberg, I., Gemma, C., Vila, J., Bickford, P.C. (2005). Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system. Exp Neurol, 196, 298-307. 

Subash, S., Essa, M.M., Al-Adwi, S., Memon, M.A., Manivasagan, T., & Akbar, M. (2014). Neuroprotective effects of berry fruits on neurodegenerative diseases.  Neural Regeneration Research, 9(16), 1557-1566. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192974/

Szajdek, A., Borowska, J.E. (2008). Bioactive compounds and health-promoting properties of berry fruits a review. Plant Foods Hum Nutr, 63,147-156. 

Wang, Y., Chang, C.F., Chou, J., Chen, H.L., Deng, X., Harvey, B.K., Cadet, J.L., Bickford, P.C. (2005). Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage. Exp Neurol, 193, 75-84. 

Williams, C.M., El Mohsen, M.A., Vauzour, D., Rendeiro, C., Butler, L.T., Ellis, J.A., Whiteman, M., Spencer, J.P. (2008). Blueberry induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radical Biol Med, 45, 295-305.

Youdim, K.A., Joseph, J.A. (2001). A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects. Free Radic Biol Med, 30, 583-594.  

Youdim, K.A., Shukitt-Hale, B., Martin, A., Wang, H., Denisova, N., Bickford, P.C., Joseph, J.A. (2000). Short-term dietary supplementation of blueberry polyphenolics: beneficial effects on aging brain performance and peripheral tissue function. Nutr Neurosci, 3, 383-397.  

Anti-Inflammatory Support

Akiyama et al. (2000). Inflammation and Alzheimer’s disease. Neurobiol Aging, 21(3), 383-421.

Grace, M.H., Esposito D., Dunlap K.L., & Lila M.A. (2014). Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries. J Agric Food Chem, 62(18), 4007-17. doi: 10.1021/jf403810y.

McAnulty, L.S. Nieman, D.C., Dumke, C.L., Shooter, L.A., Henson, D.A., Utter, A.C., … McAnulty, S.R. (2011). Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running. Appl Physio Nutr Metab, 36(6), 976-84.

Blueberry and Heart Health

Louis, X.L., Thandapilly, S.J., Kalt, W., Vinqvist-Tymchuk, M., Aloud, B.M, Raj, P., … Netticadan, T. (2014). Blueberry polyphenols prevent cardiomyocyte death by preventing calpain activation and oxidative stress. Food Funct, 5(8), 1785-94. doi: 10.1039/c3fo60588d.

The Bioavailability of Anthocyanin For Health

Lila, M.A., Burton-Freeman, B., Grace, M., & Kalt, W. (2016). Unraveling Anthocyanin Bioavailability for Human Health. Annu Rev Food Sci Technol,7, 375-93. doi: 10.1146/annurev-food-041715-033346.

Sandhu, A.K., Huang, Y., Xiao, D., Par, E., Edirisinghe, I., & Burton-Freeman, B. (2016). Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake. J Agric Food Chem, 64(24), 4891-9. doi: 10.1021/acs.jafc.6b00805.

Ingredients

Ingredients

One Vegetarian Capsule Contains: 
Blueberry (Vaccinium corymbosum) Freeze-dried Extract (80:1)  500mg 
  Anthocyanins 12% Typical 
  Polyphenos 40% Minimum 
  Chlorogeninc Acid 5% Minimum 
  ORAC units per gram 6500 

Typical Other Ingredients cellulose & water (capsule shell)

Suggested Use

Suggested Use

1 capsule daily or as directed by your healthcare practitioner

Servings per container:  60

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