Cranberry Pomegranate Synbiotic Formula

The Cranberry Pomegranate Synbiotic Formula offers an essential support for the urinary tract system. A new advanced extraction technology produces the high potency phenolic extracts of organic cranberry and pomegranate.

Together with three specifically researched Bulgarian probiotic strains, our famous Supernatant metabolite mix, D-mannose, and organic chicory soluble fiber, the Cranberry Pomegranate Synbiotic Formula is unique and effective.

$61.74

Availability: In stock

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Description

Details

15 billion cfu/cap of certified strains of Traditional Bulgarian pedigreed probiotic with Therapeutic Foods in a synbiotic formula containing: L. casei, L. acidophilus, and B. longum plus Supernatant (inactive cells of L. bulgaricus, S. thermophilus and their metabolites) along with Cranberry Extract, organic, freeze dried; Pomegranate Extract, organic, freeze dried; Inulin from chicory root and D-Mannose, an essential sugar.

Advanced freeze-drying technology. 60 caps/bottle. 500 mg/cap. No excipients.

  • Combination of Green Technology for highest phytonutrient potential and Microbiome Technology for pure cultures of Traditional Bulgarian strains of standardized referenced material with molecular identity confirmed routinely by DNA sequencing.
  • Designed to provide powerful support for healthy urinary tract function, the Cranberry Pomegranate Synbiotic Formula contains: Cranberry Extract, organic, freeze dried (125mg); Pomegranate Extract, organic, freeze dried (62.5mg); Traditional Bulgarian Strains - L. casei, L. acidophilus, and B. longum(15 billion); Supernatant- inactive cells of L. bulgaricus, S. thermophilus plus their metabolites (62.5mg); Inulin from chicory root (62.5mg) and D-Mannose, an essential sugar (62.5mg), in a 500mg vegetarian capsule.
  • Rigorously standardized organic freeze-dried Cranberry Extract containing exceptionally high levels of organic acids, proanthocyanins, anthocyanins, phenols, quinic acid, ellagic acid and quercetin, provides unique bacterial anti-adhesion properties for support of healthy resistance to uro-genital infections. Traditionally, cranberry has been used for the treatment and prophylaxis of urinary tract infections. Recent controlled trials support the use of cranberry for UTI. The mechanism of action focus primarily on the cranberry’s ability to prevent bacterial binding to host cell surface membranes. Specifically, cranberry inhibits hemagglutination of E. coli by expression of types 1 and P adhesins through the component compounds fructose and proanthocyanadins.
  • Pomegranate supports a healthy inflammatory response, lipid levels, and resistance to infection. Supports healthy cardiovascular function. In combination with the cranberry fruit and extract, the pomegranate suppresses bacterial and fungal growth.
  • Traditional Bulgarian Strains support healthy immune response and resistance to infection by colonizing the GI tract, thereby protecting the membrane from colonization by pathogenic organisms, reducing the intestinal pH which creates an unfavorable environment for E. coli and other potential pathogens, and producing antibiotic-like substances called bacteriocines. They stimulate healthy SigA production, as well as reduce pro-inflammatory cytokine profiles. They increase glycosylation of intestinal mucins (MUC2 and MUC3), which protects the intestinal cells against pathogenic adhesion.
  • Supernatant inactive cells and metabolites act as antigens stimulating a healthy innate immune response, and cell-mediated and humoral immune response to provide rapid and strong resistance against bacteria and viruses. (For more discussion on the Traditional Bulgarian Strains and Supernatant please go to the library and select Supernatant Synbiotic dossier).
  • D-Mannose is a naturally occurring essential sugar closely related to glucose. Unlike glucose, D-mannose is not converted to glycogen or stored in the liver, but is transported directly to the blood stream by the small intestine, where it is subsequently filtered through the mucus of the urinary tract. When D-Mannose is introduced, the E. coli preferably attach to the D-mannose molecules- forming a complex that is expelled in the urine. In combination with the Traditional Bulgarian Strains and the Cranberry Extract, D-Mannose provides a potent synergistic effect for urinary tract health.
  • Inulin is a NDO (non digestible oligosaccharides) that serves as a source of food for Bifidobacteria and Lactobaccillus in the large intestine. It promotes the lowering of the pH of the GI tract membrane creating an unfavorable environment for pathogenic bacteria.
  • No filler, flowing agents or excipients of any kind.
Research

Research

BIBLIOGRAPHY

Historical and Clinical Review of Cranberries

Neto, C.C., & Vinson, J.A. (2011). Cranberry. In I.F.F., Benzie, & S. Wachtel-Galor (Eds.), Herbal medicine: Biomolecular and clinical aspects. 2nd edition. Boca Raton, FL: CRC Press/Taylor & Francis.

Cranberries for Bladder and UTI Support and Management

Avorn, J., Monane, M., Gurwitz. J.H., Glynn. R.J., Choodnovskiy, I., Lipsitz, L.A. (1994). Reduction ofbacteriuria and pyuria after ingestion of cranberry juice. J Am Med Assoc, 271, 751–4.

Bailey, D.T., Dalton, C., Daugherty, F.J., & Tempesta, M.S. (2007). Can a concentrated cranberry extract prevent recurrent urinary tract infections in women? A pilot study. Phytomed, 14, 237–41.

Di Martino, P., Agniel, R., David, K., Templer, C., Gaillard, J.L., Denys, P., & Botto, H. (2006). Reduction of Escherichia coli adherence to uroepithelial bladder cells after consumption of cranberry juice: A double-blind,randomized placebo-controlled cross-over trial. WorldJ Urol, 24, 21–7.

Howell, A.B., Botto, H., Combescure, C., Blanc-Potard, A.B., Gausa, L., Matsumoto, T., … Lavigne, J.P. (2010). Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infect Dis, 10, 95. doi: 10.1186/1471-2334-10-94.

Howell A.B, Vorsa N, Der Marderosian A, Foo L.Y. (1998). Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries. N Eng J Med, 339,1085–6.

Jepson, R.G., & Craig, J.C. (2008). Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev, CD001321.

McMurdo, M.E., Bissett, L.Y., Price, R.J., Phillips, G., & Crombie, I.K. (2005). Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing, 34(3), 256-61.

McMurdo, M.E., Argo, I., Phillips, G., Daly, F., & Davey, P. (2009). Cranberry or trimethoprim for the prevention of recurrent urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother, 63, 389–95

Sobota, A.E. (1984). Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infections. J Urol, 131(5), 1013-6.

Stothers L. (2002). A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women. Can J Urol, 9, 1558–62.

Tao, Y., Pinzon-Arango, P.A., Howel, A.B., & Camesano, T.A. (2011). Oral consumption of cranberry juice cocktail inhibits molecular-scale adhesion of clinical uropathogenic Escherichia coli. J Med Food, 14(7-8), 739-45.

Wing, D.A., Rumney, P.J., Preslicka, C.W., & Chung, J.H. (2008). Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: A randomized, controlled pilot study. J Urol, 180,1367–72.

Cranberries and the addition of Antimicrobial for UTI Support*

Greelings, A.E. (2011). Should we prevent or even treat urinary tract infections with cranberries? Future Microbiology, 6(12), 1385-1386.

Hisano, M., Bruschini, H., Nicodemo, A.C., & Srougi, M. (2012). Cranberries and lower urinary tract infection prevention. CLINICS, 67(6), 661-667.

McMurdo, M.E., Argo, I., Phillips, G., Daly, F., & Davey, P. (2009). Cranberry or trimethoprim for the prevention of recurrent urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother, 63(2), 389-95.

Cranberries and Helicobacter Pylori

Burger, O., Ofek, I., Tabak, M., Weiss. E.I,, Sharon, N., & Neeman, I. (2000). A high molecular mass constituent of cranberry juice inhibitsHelicobacter pylori adhesion to human gastric mucus. FEMS Immunol Med Microbiol, 29, 295–301.

Matsushima, M., Suzuki, T., Masui, A., (Edss). (2008). Growth inhibitory action of cranberry on Helicobacter pylori. J Gastroenterol Hepatol, 2, S175–80.

Zhang, L., Ma, J., Pan, K., Go, V.L., Chen, J., You, W.C. (2005). Efficacy of cranberry juice on Helicobacter pylori infection: A double-blind randomized placebo-controlled trial. Helicobacter, 10, 139–45.

Cranberries for High Antioxidant and Anti-Inflammatory Support

Seeram, N.P., Momin, R.A., Nair, M.G., & Bourquin, L.D. (2001). Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomed, 8, 362–9.

Seeram, N.P., Zhang, Y., & Nair, M.G. (2003). Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. Nutr Cancer, 46, 101–6.

Vinson, J.A., Bose, P., Proch, J. AI Kharrant, H., & Samman, N. (2008). Cranberries and cranberry products: powerful in vitro, ex vivo, and in vivo sources of antioxidants. J Agric Food Chem, 56(14), 5884-91. doi: 10.1021/jf073309b.

Pomegranate and Cancer Support

Seeram, N.P. (2008). Berry fruits for cancer prevention: current status and future prospects. J Agric Food Chem; 56(3): 630-5.

Pomegranate and Alzheimer’s Disease Support

Yan, T., Ma, H., Liu, W., Niesen, D.B., Shah, N., Crews, R., … Seeram, N.P. (2016). Pomegranate's Neuroprotective Effects against Alzheimer's Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites. ACS Chem Neurosci, 7(1), 26-33. doi: 10.1021/acschemneuro.5b00260

Pomegranate and Cranberries for Prostate Support

Deziel, B., MacPhee, J., Patel, K. Catalli, A., Kulka, M., Neto, C., … Hurta, R. (2012). American cranberry (Vaccinium macrocarpon) extract affects human prostate cancer cell growth via cell cycle arrest by modulating expression of cell cycle regulators. Food Funct, 3(5), 556-64. doi: 10.1039/c2fo10145a.

Hong, M.Y., Seeram, N.P., & Heber, D. (2008). Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. J Nutr Biochem, 19(12), 848-55.

Koyama, S., Cobb, L.J., Mehta, H.H., Seeram, N.P., Heber, D., Pantuck, A.J., & Cohen, P. (2010). Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis. Growth Horm IGF Res, 20(1), 55-62.

Pantuck, A.J., Leppert, J.T., Zomorodian, N., Aronson, W., Hong, J., Barnard, R.J., … Belldegrun, A. (2006). Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res, 12(13), 4018-26.

Retting, M.B., Heber, D., An, J. Seeram, N.P., Rao, J.Y., Rao, J.Y., Liu, H., … Pantuck, A. (2008). Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism. Mol Cancer ther, 7(9), 2662-71.

Seeram, N.P., Aronson, W.J., Zhang, Y., Henning, S.M., Moro, A., Lee, R.P., … Heber, D. (2007). Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J Agric Food Chem, 55(19), 7732-7.

Seeram, N.P., Henning, S.M., Zhang, Y., Suchard, M., Li, Z., & Heber, D. (2006). Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. J Agric Food Chem, 136(10), 2481-5.

Seeram, N.P., Adams, L.S., Hardy, M.L., & Heber, D. (2004). Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J Agric Food Chem, 52(9), 2512-7.

Pomegranate and Cognitive Support

Essa, M.M., Subash, S., Akbar, M., Al-Adawi, S., & Guillemin, G.J. (2015). Long-term dietary supplementation of pomegranates, figs and dates alleviate neuroinflammation in a transgenic mouse model of Alzheimer's disease. PLoS One, 10(3). doi: 10.1371/journal.pone.0120964.

Pomegranate and Age-Related Degeneration Support

Braidy, N., Selvaraju, S., Essa, M.M., Vishnav, R., Al-Adawi, S., Al-Senawi, H., … Guillemin, G.J. (2013). Neuroprotective effects of a variety of pomegranate juice extracts against MPTP-induced cytotoxicity and oxidative stress in human primary neurons. Oxid Med Cell Longev. doi: 10.1155/2013/685909.

The Bioavailability of Anthocyanin For Health

Grace, M.H., Massey, A.R., Mbeunkui. F., Yousef, G.G., & Lila, M.A. (2012). Comparison of health-relevant flavonoids in commonly consumed cranberry products. J Food Sci, 77(8), H176-83. doi: 10.1111/j.1750-3841.2012.02788.x.

Lila, M.A., Burton-Freeman, B., Grace, M., & Kalt, W. (2016). Unraveling Anthocyanin Bioavailability for Human Health. Annu Rev Food Sci Technol,7, 375-93. doi: 10.1146/annurev-food-041715-033346.

Carlsen, M.H., Halvorsen, B.L., Holte, K., Bohn, S.K., Dragland, S., Sampson, L., … Blomhoff, R. (2010). The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr J, 9,3. doi: 10.1186/1475-2891-9-3

Sandhu, A.K., Huang, Y., Xiao, D., Par, E., Edirisinghe, I., & Burton-Freeman, B. (2016). Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake. J Agric Food Chem, 64(24), 4891-9. doi: 10.1021/acs.jafc.6b00805.

* the argument whether cranberry alone is enough for supporting UTI is still ongoing, however, combining cranberry with an antimicrobial that is natural is promising. For a natural antimicrobial support, please see the Organic Garlic on the Product Page.

Ingredients

Ingredients

One Capsule Contains: 
Cranberry extract, organic, freeze-dried 125mg 
Pomegranate extract, organic, freeze-dried 82.5mg 
Probiotic 15 billion CFU 
Lactobacillus casei 31.25mg 
Lactobacillus acidophilus
 31.25mg 
Bifidobacterium longum 62.5mg 
Supernatant: inactive cells of L. bulgaricus and S. thermophilus plus metabolites 62.5mg 
Inulin 62.5mg 
D-Mannose 62.5mg

Other Ingredients: 
Cellulose & water (capsule shell)

Suggested Use

Suggested Use

1 to 2 capsules daily or as directed by your healthcare practitioner.

Servings per container: 60

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