Original Synbiotic

20 billion cfu/tsp of certified strains of pedigreed probiotic with Therapeutic Foods in a synbiotic formula of L. acidophilus, B. longum, L. rhamnosus, L. plantarum, S. thermophilus and 4 grams of inulin derived from organic chicory fiber. Advanced freeze-drying technology. 120 grams/bottle. 4 grams/ tsp. Dairy free.  Soy free. Gluten free. No excipients.

• Microbiome Technology creates hardy and viable pedigreed strains of L. acidophilus, B. longum, L. rhamnosus, L. plantarum, S. thermophilus.
• Original strains of lactic acid bacteria are based on ATCC prototypical strains and confirmed routinely by 16sRNA sequencing to provide highest quality probiotic material.
• The Original Strains are chosen for their strength, compatibility, safety and their 40 years of proven ability to neutralize food borne pathogens and xenobiotics.
  • Strains selected to protect, counteract and neutralize dietary toxins, mutagens, carcinogens and infectious organisms.
  • The contamination of food with aflatoxins is a worldwide problem. Mold mycotoxins compromise the blood-brain barrier and induce neurodegenerative processes. L rhamnosus binds AFB1 in vivo and reduces bio-absorption of the toxin from the gut. L. acidophilus and B. longum neutralize AFB1 and AFM1 by binding mechanisms. S. thermophilus reduces content of ochratoxin A.
  • Mutagens cause impaired cell function, cell death or cell transformation into cancer cells. L. acidophilus, B. longum, L. rhamnosus, S. thermophilus and L. plantarum neutralize heterocyclic amines and nitrosamines, two of the most common and powerful mutagenic molecules found in our diet.
• Our home is a global environment. Infectious organisms come from all corners of the world.
  • Verocytotoxin producing E. coli s0157 are emerging food borne pathogens worldwide. B. longumneutralizes this toxin.
  • The collective ability of the Original probiotic organisms to protect the frontline border of our GI tract membrane from the aggressive enterovirulent pathogens is accomplished via: the production of bactercins, creation of an acid barrier, stimulation of the cell mediated immune system and protective colonization of enterocytes.
• The lactic acid bacterial strains in the Original Synbiotic Formula have demonstrated the ability to inhibit the formation of precancerous colon lesions. Numerous trials performed validate findings.
• Pure inulin, derived from chicory fiber, provides support as a Therapeutic Foods carrier and prebiotic. Provides an ideal food source for the lactic acid organisms to grow, thrive and to protect.
• In the process of fermentation, inulin produces butyric acid and therefore:
  • Corrects GI permeability- establishes tight junctions.
  • Inhibits colon cancer: stimulating the differentiation of stem cells.
• Improves habit of bowel regularity
• No fillers, flowing agents or excipients of any kind.

Ingredients

 

1 Teaspoon Contains: 
Calories 5 
Total Carbohydrate 3g 
Dietary fiber 3g 
Soluble fiber 3g 
Proprietary Probiotic Blend 20billion CFU    3.38g 
  L. acidophilus 
  L. casei rhamnosus 
  L. plantarum 
  S. thermophilus 
  B. longum 
Inulin (from organic chicory root)

Container:  120 grams

Research

Immune Support

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Cianci, R., Franza, L., Schinzari, G., Rossi, E., Ianiro, G., Tortora, G., ... & Cammarota, G. (2019). The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer. International journal of molecular sciences, 20(3), 501. Abstract

Dargahi, N., Johnson, J., Donkor, O., Vasiljevic, T., & Apostolopoulos, V. (2018). Immunomodulatory effects of Streptococcus thermophilus on U937 monocyte cell cultures. Journal of Functional Foods, 49, 241-249. https://doi.org/10.1016/j.jff.2018.08.038

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Shmaryahu, A., Carrasco, M., & Valenzuela, P. D. (2014). Prediction of bacterial microRNAs and possible targets in human cell transcriptome. Journal of Microbiology, 52(6), 482-489. Abstract

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Zhao, Y., & Lukiw, W. J. (2018). Microbiome-mediated upregulation of microRNA-146a in sporadic Alzheimer’s disease. Frontiers in neurology, 9, 145. Article

IBS:  Inflammatory Bowel Support

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Dimidi, E., Christodoulides, S., Scott, S. M., & Whelan, K. (2017). Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation. Advances in Nutrition, 8(3), 484-494. Article

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Lin, P.W., Myers, L.E., Ray, L., Song, S.C., Nasr, T.R., Berardinelli, A.J., Kundu, K., Murthy, N., Hansen, J.M., & Neish A.S. (2009). Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free Radic. Biol. Med, 47, 1205–1211. doi: 10.1016/j.freeradbiomed.2009.07.033.

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Zhang, Y., Li, L., Guo, C., Mu, D., Feng, B., Zuo, X., & Li, Y. (2016). Effects of probiotic type, dose and treatment duration on irritable bowel syndrome diagnosed by Rome III criteria: a meta-analysis. BMC gastroenterology, 16(1), 62. Abstract

Modulating a Healthy Microbiome: Immunity, Intestinal Barrier & Brain

Arora, T., & Bäckhed, F. (2016). The gut microbiota and metabolic disease: current understanding and future perspectives. Journal of internal medicine, 280(4), 339-349. Article

Blackwood, B. P., Yuan, C. Y., Wood, D. R., Nicolas, J. D., Grothaus, J. S., & Hunter, C. J. (2017). Probiotic Lactobacillus species strengthen intestinal barrier function and tight junction integrity in experimental necrotizing enterocolitis. Journal of probiotics & health, 5(1). Article

Bosscher, D., Breynaert, A., Pieters, L., & Hermans, N. (2009). Food-based strategies to modulate the composition of the microbiota and their associated health effects. Journal of physiology and pharmacology/Polish Physiological Society.-Kraków, 1991, currens, 60(S: 6), 5-11. Article

Bron, P. A., Kleerebezem, M., Brummer, R. J., Cani, P. D., Mercenier, A., MacDonald, T. T., ... & Wells, J. M. (2017). Can probiotics modulate human disease by impacting intestinal barrier function?. British Journal of Nutrition, 117(1), 93-107. Abstract

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Choudhury, T. G., & Kamilya, D. (2018). Paraprobiotics: an aquaculture perspective. Reviews in Aquaculture. Abstract

de Vos, P., Mujagic, Z., de Haan, B. J., Siezen, R. J., Bron, P. A., Meijerink, M., ... & Troost, F. J. (2017). Lactobacillus plantarum Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal Anti-inflammatory Drug Induced Reduction in T Regulatory Cells. Frontiers in Immunology, 8, 1000. DOI:

10.3389/fimmu.2017.01000

De Vrese, M., & Schrezenmeir, J. (2008). Probiotics, prebiotics, and synbiotics. Adv. Biochem. Eng. Biotechnol, 111, 1–66. Abstract

Dinan, T. G., & Cryan, J. F. (2017). Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration. The Journal of physiology, 595(2), 489-503. Article

Gibson, G.R., Probert, H.M., van Loo, J.A.E., & Roberfroid, M.B. (2004). Dietary modulation of the human colonic microbiota: Updating the concept of prebiotics. Nutr. Res. Rev, 17, 257–259. Abstract

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Hu, S., Wang, L., & Jiang, Z. (2017). Dietary Additive Probiotics Modulation of the Intestinal Microbiota. Protein and peptide letters, 24(5), 382-387. DOI:10.2174/0929866524666170223143615

Kechagia, M., Basoulis, D., Konstantopoulou, S., Dimitriadi, D., Gyftopoulou, K., Skarmoutsou, N., & Fakiri, E. M. (2013). Health benefits of probiotics: a review. ISRN nutrition, 2013.  http://dx.doi.org/10.5402/2013/481651

Macfarlane, S. M. G. T., Macfarlane, G. T., & Cummings, J. T. (2006). Prebiotics in the gastrointestinal tract. Alimentary pharmacology & therapeutics, 24(5), 701-714. Article

Maguire, M., & Maguire, G. (2019). Gut dysbiosis, leaky gut, and intestinal epithelial proliferation in neurological disorders: towards the development of a new therapeutic using amino acids, prebiotics, probiotics, and postbiotics. Reviews in the Neurosciences, 30(2), 179-201. Article

Manzoni, P., Mostert, M., Leonessa, M. L., Priolo, C., Farina, D., Monetti, C., ... & Gomirato, G. (2006). Oral supplementation with Lactobacillus casei subspecies rhamnosus prevents enteric colonization by Candida species in preterm neonates: a randomized study. Clinical infectious diseases, 42(12), 1735-1742. Article

Mujagic, Z., De Vos, P., Boekschoten, M. V., Govers, C., Pieters, H. J. H., De Wit, N. J., ... & Troost, F. J. (2017). The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial. Scientific reports, 7, 40128. DOI:10.1038/srep40128

Nishiyama, K., Sugiyama, M., & Mukai, T. (2016). Adhesion properties of lactic acid bacteria on intestinal mucin. Microorganisms, 4(3), 34. Abstract

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Roberfroid M. (2007). Prebiotics: The concept revisited. J. Nutr, 137, 830–837. Article

Roberfroid, M. B. (2002). Functional foods: concepts and application to inulin and oligofructose. British Journal of Nutrition, 87(S2), S139-S143. https://doi.org/10.1079/BJN/2002529

Sirisinha, S. (2016). The potential impact of gut microbiota on your health: Current status and future challenges. Asian Pac J Allergy Immunol, 34(4), 249-264. Article

Thomas, L. V., Suzuki, K., & Zhao, J. (2015). Probiotics: a proactive approach to health. A symposium report. British Journal of Nutrition, 114(S1), S1-S15. Abstract

Tufarelli, V., & Laudadio, V. (2016). An overview on the functional food concept: prospectives and applied researches in probiotics, prebiotics and synbiotics. J Exp Bioland Agric Sci, 4(3), 273-8. Article

Tsilingiri, K., & Rescigno, M. (2012). Postbiotics: what else?. Beneficial microbes, 4(1), 101-107. Abstract

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Yin, X., Lee, B., Zaragoza, J., & Marco, M. L. (2017). Dietary perturbations alter the ecological significance of ingested Lactobacillus plantarum in the digestive tract. Scientific reports, 7(1), 7267. Abstract

Babies and Young Children’s Microbiome

Amenyogbe, N., Kollmann, T. R., & Ben-Othman, R. (2017). Early-life host–microbiome interphase: the key frontier for immune development. Frontiers in pediatrics, 5, 111. DOI:10.3389/fped.2017.00111

Blanton, L. V., Barratt, M. J., Charbonneau, M. R., Ahmed, T., & Gordon, J. I. (2016). Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics. Science, 352(6293), 1533-1533. DOI: 10.1126/science.aad9359

Cox, M. J., Huang, Y. J., Fujimura, K. E., Liu, J. T., McKean, M., Boushey, H. A., ... & Lynch, S. V. (2010). Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome. PLoS One, 5(1), e8745. Article

Emami, C. N., Petrosyan, M., Giuliani, S., Williams, M., Hunter, C., Prasadarao, N. V., & Ford, H. R. (2009). Role of the host defense system and intestinal microbial flora in the pathogenesis of necrotizing enterocolitis. Surgical infections, 10(5), 407-417. Abstract

Goldenberg, J. Z., Lytvyn, L., Steurich, J., Parkin, P., Mahant, S., & Johnston, B. C. (2015). Probiotics for the prevention of pediatric antibiotic‐associated diarrhea. The Cochrane Library. Abstract

Hodzic, Z., Bolock, A. M., & Good, M. (2017). The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis. Frontiers in pediatrics, 5, 40.Article

Hayes, S. R., & Vargas, A. J. (2016). Probiotics for the Prevention of Pediatric Antibiotic-Associated Diarrhea. Explore: The Journal of Science and Healing, 12(6), 463-466. https://doi.org/10.1016/j.explore.2016.08.015

Kang, D. W., Ilhan, Z. E., Isern, N. G., Hoyt, D. W., Howsmon, D. P., Shaffer, M., ... & Krajmalnik-Brown, R. (2018). Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders. Anaerobe, 49, 121-131. Article

Patel, R.M., & Denning, P.W. (2013). Therapeutic use of prebiotics, probiotics, and postbiotics to prevent necrotizing enterocolitis: What is the current evidence? Clin Perinatol, 40(1), 11-25. Article

Shankar, V., Gouda, M., Moncivaiz, J., Gordon, A., Reo, N. V., Hussein, L., & Paliy, O. (2017). Differences in gut metabolites and microbial composition and functions between Egyptian and US children are consistent with their diets. Msystems, 2(1), e00169-16. Article

Subramanian, S., Huq, S., Yatsunenko, T., Haque, R., Mahfuz, M., Alam, M. A., ... & Barratt, M. J. (2014). Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature, 510(7505), 417. Abstract

Wegh, C. A., Schoterman, M. H., Vaughan, E. E., Belzer, C., & Benninga, M. A. (2017). The effect of fiber and prebiotics on children’s gastrointestinal disorders and microbiome. Expert review of gastroenterology & hepatology, 11(11), 1031-1045. https://doi.org/10.1080/17474124.2017.1359539

Zhang, M., Ma, W., Zhang, J., He, Y., & Wang, J. (2018). Analysis of gut microbiota profiles and microbe-disease associations in children with autism spectrum disorders in China. Scientific reports, 8(1), 13981. Article

Metabolic Support: Cardiovascular, Diabetes, Cancer, and Weight

Cani, P.D., Pssemiers, S., Van de Wiele, T., Guiot, Y., Everad, A., Rottier, O…. Delzenne, N.M. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut, 58(8), 1091-1103. DOI:10.1136/gut.2008.165886

Cani, P. D. (2019). Severe obesity and gut microbiota: does bariatric surgery really reset the system?. Gut, 68(1), 5-6. Abstract

Cani, P. D., & Delzenne, N. M. (2009). The role of the gut microbiota in energy metabolism and metabolic disease. Current pharmaceutical design, 15(13), 1546-1558. Article

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet–induced obesity and diabetes in mice. Diabetes, 57(6), 1470-1481. Article

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., ... & Waget, A. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 56(7), 1761-1772. Article

Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R. G., Tuohy, K. M., ... & Delzenne, N. M. (2007). Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia, 50(11), 2374-2383. Article

Druat, C., Alligier, M., Salazar, N., Neyrinck, A.M., & Delzenne, N.M. (2014). Modulation of the gut microbiota by nutrients with prebiotic and probiotic properties. Adv Nur, 5(5), 624S-633S. DOI:10.3945/an.114.005835

Everard, A., & Cani, P. (2013). Diabetes, obesity and gut microbiota. Best Pract. Res. Clin. Gastroenterol, 27, 73–83. Article

Falcinelli, S., Rodiles, A., Hatef, A., Picchietti, S., Cossignani, L., Merrifield, D. L., ... & Carnevali, O. (2017). Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity and enhances catabolic hormonal milieu in zebrafish. Scientific reports, 7(1), 5512. Article

Frazier, T. H., DiBaise, J. K., & McClain, C. J. (2011). Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury. Journal of Parenteral and Enteral Nutrition, 35(5_suppl), 14S-20S. Article

Han, J. L., & Lin, H. L. (2014). Intestinal microbiota and type 2 diabetes: from mechanism insights to therapeutic perspective. World journal of gastroenterology: WJG, 20(47), 17737. Article

Korkmaz, O. A., Sadi, G., Kocabas, A., Yildirim, O. G., Sumlu, E., Koca, H. B., ... & Bilgehan, M. Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome. Article

Macfarlane, S., Cleary, S., Bahrami, B., Reynolds, N., & Macfarlane, G. T. (2013). Synbiotic consumption changes the metabolism and composition of the gut microbiota in older people and modifies inflammatory processes: a randomised, double‐blind, placebo‐controlled crossover study. Alimentary pharmacology & therapeutics, 38(7), 804-816. Article

Marques, F. Z., Mackay, C. R., & Kaye, D. M. (2018). Beyond gut feelings: how the gut microbiota regulates blood pressure. Nature Reviews Cardiology, 15(1), 20. Article

Qin, Y., Roberts, J. D., Grimm, S. A., Lih, F. B., Deterding, L. J., Li, R., ... & Wade, P. A. (2018). An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression. Genome biology, 19(1), 7. Article

Roberfroid, M., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R., Rowland, I., ... & Guarner, F. (2010). Prebiotic effects: metabolic and health benefits. British Journal of Nutrition, 104(S2), S1-S63. Abstract

Serino, M., Blasco-Baque, V., Nicolas, S., & Burcelin, R. (2014). Managing the manager: gut microbes, stem cells and metabolism. Diabetes & metabolism, 40(3), 186-190. Abstract

Yan Q, Li X, Feng B. (2015). The efficacy and safety of probiotics intervention in preventing conversion of impaired glucose tolerance to diabetes: study protocol for a randomized, double-blinded, placebo controlled trial of the Probiotics Prevention Diabetes Programme (PPDP). BMC Endocr Discord; 15(1): 74. Article

Cardiovascular and Fatty Liver Support

Álvarez-Mercado, A. I., Navarro-Oliveros, M., Robles-Sánchez, C., Plaza-Díaz, J., Sáez-Lara, M. J., Muñoz-Quezada, S., ... & Abadía-Molina, F. (2019). Microbial Population Changes and Their Relationship with Human Health and Disease. Microorganisms, 7(3), 68. Article

Delzenne, N. M., Knudsen, C., Beaumont, M., Rodriguez, J., Neyrinck, A. M., & Bindels, L. B. (2019). Contribution of the gut microbiota to the regulation of host metabolism and energy balance: a focus on the gut–liver axis. Proceedings of the Nutrition Society, 1-10. Abstract

Fernandes, R., do Rosario, V. A., Mocellin, M. C., Kuntz, M. G., & Trindade, E. B. (2017). Effects of inulin-type fructans, galacto-oligosaccharides and related synbiotics on inflammatory markers in adult patients with overweight or obesity: A systematic review. Clinical Nutrition, 36(5), 1197-1206. Abstract

Iacono, A., Raso, G. M., Canani, R. B., Calignano, A., & Meli, R. (2011). Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms. The Journal of nutritional biochemistry, 22(8), 699-711. Article

Johnson-Henry et al. (2008). Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli 0157:H7- Induced changes in epithelial barrier function. Infect Immun; 76:1340-1348. Abstract

Lee et al. (2006). Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. Biochim Biophys Acta; 1761: 736-744. Article

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Protocol

 

ORIGINAL — The Original is designed as a foundational probiotic formula for the whole family.

Hard working probiotic: The Original is designed to handle and neutralize carcinogens, toxins, molds, yeasts, and food pathogens (e.g., salmonella). The probiotic mix binds heavy metals. Take 1 teaspoon a day. For babies, start with a few grains (mothers can dip their pinkie in the mix to feed the baby). Sensitive individuals start with ¼ teaspoon and gradually up the dosage.* 

leaky gut: The Original creates a slightly acidic pH level in the GI Tract to protect the gut membrane from pathogens like yeast. The mix produces amazingly high amounts of the short chain fatty acid butyrate, which facilitate the tightening of the gut membrane. Take 1 teaspoon daily (can take 1 teaspoon three times day during acute bouts of gastric distress).*

Digestion: Take 1 teaspoon to improve digestion, dissolve in mouth slowly. The Original in fact helps the digestion of polyphenols from fruits, berries, veggies, and greens into bioavailable shorter chains of phenolic molecules. The Original also helps digest complex carbohydrates into short chain fatty acids, important for gut health.*

Microbiome and healthy diversity: The Original has team playing organisms that help to build healthier communities in the gut.