Activating AMPK with Specific Polyphenols & Probiotics: Energy, Anti-Inflammatory, Weight Loss
We all seem to need more energy, so when an article comes along, by scientists that have studied and understand AMPK, we do listen.
We have looked at a foundational article about AMPK with 3000 citations by scientists all over the world.
How about almost 4500 citations? This hard working group of Hardie et al., 2012, go over the many functions of AMPK, and it is worth understanding for solving difficult to treat conditions.
For those of us who are jumping into this conversation, AMPK is AMP-activated protein kinase or 5' adenosine monophosphate-activate protein kinase. An enzyme that is a switch of a sort, or an energy sensor (Hardie et al., 2012).
How does it work? To simplify matters, AMPK activates ATP, which is our energy source in every cell, or conserves ATP, depending on the needs of our body. It is central to many health promoting processes, such as anti-inflammation, antioxidant function, regulation of metabolism and cell cycles, insulin regulation. Cellular homeostasis is key in ongoing health maintenance.
The more I read about AMPK - and there are some amazing recent literature that discusses fatty liver (Fang et al., 2022), chronic kidney disease (Juszczak et al., 2020), and obesity and weight loss (canbolat & Cakiroglu, 2023) - the more I want to know how to ensure this powerful enzyme has all the support it needs.
What supports and activates AMPK?
Exercise, and here I would emphasize hard exercise! (Richter & Ruderman, 2009; Gurd et al., 2023).
The literature is filled with articles about the importance of polyphenols (Li et al., 2023; Sotoudeheian & Hoseini, 2023, Xu et al., 2023, Zang et al., 2006) and its affect on AMPK and health of liver, kidneys, energy, weight loss, fatty liver, metabolism and heart health. It is astonishing.
There is also the microbiome and its importance to maintaining a good functioning AMPK (Li et al., 2024), and for this area I have chosen a most recent article from this year.
Check out the references and choose an article or two. It is important knowledge.
Enjoy!
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References:
- Canbolat, E., & Cakıroglu, F. P. (2023). The importance of AMPK in obesity and chronic diseases and the relationship of AMPK with nutrition: a literature review. Critical Reviews in Food Science and Nutrition, 63(4), 449-456. Abstract
- Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012). AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nature reviews Molecular cell biology, 13(4), 251-262. Article
- Fang, C., Pan, J., Qu, N., Lei, Y., Han, J., Zhang, J., & Han, D. (2022). The AMPK pathway in fatty liver disease. Frontiers in Physiology, 13, 970292. Article
- Gurd, B. J., Menezes, E. S., Arhen, B. B., & Islam, H. (2023, July). Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA. In Seminars in Cell & Developmental Biology (Vol. 143, pp. 17-27). Academic Press.
- Juszczak, F., Caron, N., Mathew, A. V., & Declèves, A. E. (2020). Critical role for AMPK in metabolic disease-induced chronic kidney disease. International journal of molecular sciences, 21(21), 7994. Article
- Li, H., Liang, J., Han, M., & Gao, Z. (2024). Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review. Journal of Advanced Research. Article
- Richter, EA, Ruderman, NB. (2009) AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J. 418(2):261-75.
- Steinberg, G. R., & Kemp, B. E. (2009). AMPK in health and disease. Physiological reviews, 89(3), 1025-1078. Article
- Sotoudeheian, M., & Hoseini, S. (2023). Therapeutic properties of polyphenols affect AMPK molecular pathway in hyperlipidemia. Article
- Xu, W., Luo, Y., Yin, J., Huang, M., & Luo, F. (2023). Targeting AMPK signaling by polyphenols: A novel strategy for tackling aging. Food & Function, 14(1), 56-73. Article
- Zang, M., Xu, S., Maitland-Toolan, K. A., Zuccollo, A., Hou, X., Jiang, B., ... & Cohen, R. A. (2006). Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor–deficient mice. Diabetes, 55(8), 2180-2191. Article
Yours as always,
Dohrea
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More Research: Peace is a State of Unity
Election time has indeed brought out our nature of being very polarized and not very patient with 'the other party' - the insults, anger, and idealism shut down any and all communications, and all we focus upon is that the other side will bring a total disaster. It is difficult to remember that the "Other" is a human being who is in fact acting exactly as you feel and act, everyone is a mirror for everyone else. So when you feel the heat of polarization bubbles within you, why not breath deeply and say to yourself that life is too important to waste with anger and separation. I would surmise that acting with kindness will bring about a better outcome for everyone than continuing on the same path. |
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