Beta Glucan Synbiotic: Heart ~ Gut Axis

Oats and oat beta glucan have enjoyed a rich cultural historicity and extensive research on heart health (Andersson & Hellstrand, 2012).

From Shaper & Jones (1959) analysis of healthy dietary habits, to the Cornell China study in 1998, and the NIH report in 2015, dietary fibers, whole plant-based foods, and exercise are shown in research to be essential for a healthy heart.

Oats and oat beta glucan are found to reduce serum LDL cholesterol (Ho et al., 2016; Zhu et al., 2015; Whitehead et al., 2014; Wolever et al., 2010), improve liver function (Chang et al., 2013), and promote bowel regularity (Clemens, 2012; Mobley et al., 2014).

Red beetroot offer a rich source of phyto-nutrients, including ascorbic acid (vitamin C), carotenoids, phenolic acids, and flavonoids. Beets provide a source of dietary nitrate, shown in research to have important implication for heart health (Kapil et al., 2014). Beet’s nutrients are shown to prevent oxidation of LDLs, lower triglycerides, and balances blood pressure (Clifford et al., 2015; Eggenbeen et al., 2016; Hobbs et al., 2013).

As a multifunctional food, beet also stimulate Phase II liver detox (Vulić et al., 2014), as well as perform a host of other health benefits, including the production of energy for exercise (Murphy et al., 2012), promotion of joint health (Pietrzkowski et al., 2010), Antioxidant (Georgiev et al., 2010), and support for individuals who undergo cancer treatments (Kapadia et al., 2013, 2011; Das et al., 2013).

Probiotics are found in research to positively effect heart health (Kassaian et al., 2017; Sáez-Lara et al., 2016; DiRienzo, 2014; Delzenne et al., 2011; Saini et al., 2010), with many researchers positing the connection between heart and gut health (Serino et al., 2014; Huang et al., 2013). The Beta Glucan was formulated to nourish both heart and gut into health.

Inulin from organic chicory root supplies food for the probiotic organisms. Probiotic organisms need fiber to grow and multiply. See Slavin (2013) on fiber as prebiotics, and Dehghan et al. (2013) on inulin and cardiovascular support.

Beta Glucan Synbiotic

Yours as always,

Dohrea 

References

• Anderson, K.E., & Hellstrand, P. (2012). Dietary oats and modulation of atherogenic pathways. Mol Nutr Food Res, 56(7), 1003-13.
• Chang, H.C., Huang, C.N., Yeh, D.M., Wang, S.J., Peng, C.H., & Wang, C.J. (2013). Oat prevents obesity and abdominal fat distribution, and improves liver function in human. Plant Foods Hum Nutr, 68(1), 18-23.
• Clemens, R., Kranz, S., Mobley, A.R., Nicklas, T.A., Raimondi, M.P., Rodriguez, J.C., … Warshaw, H. (2012). Filling American’s fiber intake gap: Summary of roundtable to probe realistic solutions with a focus on grain-based foods. J Nutr, 142(7), 1390-1401.
• Clifford T, Howatson G, West DJ, Stevenson EJ. (2017). Beetroot Juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab.
• Das, S., Fillippone, S.M., Williams, D.S., Das, A., Kukreja, R.C. (2016). Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells. Mol Cell Biochem, 421(1-2), 89-101.
• Das, S., Williams, D.S., Das, A., Kukreja, R.C. (2013). Beet root juice promotes apoptosis in oncogenic MDA-MB-231 cells while protecting cardiomyocytes under doxorubicin treatment. J. Exp. Second. Sci, 2, 1–6. 
• Dehghan, P., Pourghassem, G.B, & Asgharijafarabadi, M. (2013). Effects of high performance inulin supplementation on glycemic status and lipid profile in women with type 2 diabetes: a randomized, placebo-controlled clinical trial. Health Promot Perspect, 3(1), 55-63.
• Eggenbeen, J., Kim-Shapiro, D.B., Haykowsky, M., Morgan, T.M., Basu, S., Brubaker, P., … Kitzman, D.W. (2016). One week of daily dosing with beetroot juice improves submaximal endurance and blood pressure in older patients with heart failure and preserved ejection fraction. JACC Heart Fail, 4(6), 428-37.
• Georgiev, V.G., Weber, J., Kneschke, E.M., Denev, P.N., Bley, T., Pavlov, A.I. (2010). Antioxidant activity and phenolic content of betalain extracts from intact plants and hairy root cultures of the red beetroot Beta vulgaris cv. Detroit dark red. Plant Foods Hum Nutr, 65 (2):105-11.
• Ho, H.V., Sievenpiper, J.L., Zurbau, A., Blanco Mejia, S., Jovanovski, E., Au-Yeung, F… Vuksan, V. (2016). The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials. Br J Nutr. 116(8):1369-1382.
• Hobbs, D.A., George, T.W., Lovegrove, J.A. (2013). The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies. Nutr Res Rev, 26(2), 210-22.
• Kapil, V., Weitzberg, E., Lundberg, J.O., Ahluwalia, A. (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health. Nitric Oxide, 38, 45-57.
• Kapadia, G.J., Rao, G.S., Ramachandran, C., Iida, A., Suzuki, N., & Tokuda, H. (2013). Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines. J Complement Integr Med., 1.
• Kapadia, G.J., Azuine, M.A., Rao, G.S, Arai, T., Lida, A., & Tokuda, H. (2011), Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines. Anticancer Agents Med Chem, 11(3), 280-4.
• Mobley, A.R., Jones, J.M., Rodriguez, J., Slavin, J., & Zelman, K.M. (2014). Identifying practical solutions to meet American’s fiber needs: Proceedings from the Food & Fiber Summit. Nutrients, 8(7), 2540-51.
• Murphy, M., Eliot, K., Heuertz, R.M., Weiss, E. (2012). Whole beetroot consumption acutely improves running performance. J Acad Nutr Diet , 112(4), 548-52.
• Shaper, A.G., & Jones, K.W. (1959). Serum-cholesterol, diet, and coronary heart disease in Africans, and Asians in Uganda.The Lancet, 275(7102), 534-37.
• Slavin, J. (2013). Fiber and prebiotics: mechanism and health benefits.Nutrients, 5(4), 1417-1435. 
• Vulić J.J., Ćebović T.N., Čanadanović-Brunet J.M., Ćetković G.S., Čanadanović V.M., Djilas S.M., Tumbas Šaponjac V.T. In vivo and in vitro antioxidant effects of beetroot pomace extracts. J. Funct. Foods. 2014;6:168–175. 
• Whitehead A, Beck EJ, Tosh S, Wolever TM. (2014). Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials. Am J Clin Nutr, 100(6), 1413-21.
• Wolever TM, Tosh SM, Gibbs AL, Brand-Miller J, Duncan AM, Hart V, Lamarche B, Thomson BA, Duss R, Wood PJ (2010). Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial. Am J Clin Nutr, 92(4):723-32.
• Zhu, X., Sun, X., Wang, M., Zhang, C., Cao, Y., Mo, G., Liang, J., Zhu, S. (2015).Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects. Nutr Metab Cardiovasc Dis, 25(8), 714-23.

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.  

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