Non Alcoholic Fatty Liver and Sulforaphane
Jinxing et al. (2021) research article on non alcoholic fatty liver and sulforaphane took my breath away - I have done much reading on this miraculous ingredient, and have seen plenty research articles. This research though is indeed fascinating.
Jinxing wanted to know if sulforaphane can improve fatty liver, and found that not only does it improve lipid accumulation, but the it does so both in vitro and in vivo.
Sulforaphane also is found to regulate insulin, to actually reducing weight, lowering cholesterol, reducing ROS (reactive oxygen species) levels, and much much more.
I do want to warn you, if you are an animal lover as we are, that this research was performed on male mice, and were, as the researchers say, anesthetized.
No time to read the whole article? The abstract is below.
Glucosinolates & Sulforaphanes
Each of our vegan capsule has 500 mg of organic broccoli sprouts, harvested at the peak of their phytonutrient power.
Abstract
Nonalcoholic fatty liver disease (NAFLD) is characterized by lipotoxicity and ectopic lipid deposition within hepatocytes. Sulforaphane (SFA), an active compound used for inhibiting tumors, was found to have the potency to improve lipid metabolism. However, its molecular mechanisms on ameliorating NAFLD are still incompletely understood. This research evaluated if SFA could inhibit hepatic steatosis and apoptosis. The effects of SFA on cell viability, lipid accumulation, triglyceride (TG) contents, apoptosis, ceramide contents, and reactive oxygen species (ROS) levels were analyzed in palmitic acid (PA)-treated HepG2 cells and high-fat diet (HFD)-fed mice. The related molecular mechanisms were further explored in hepatocytes. The results showed SFA alleviated lipid accumulation and regulated AMPK/SREBP1c/FAS signaling pathway in PA-stressed HepG2 cells. In addition, SFA alleviated PA-mediated apoptosis, downregulated the expressions of cleaved caspase 3, as well as reduced ceramide contents and ROS levels. Moreover, SFA treatment reduced HFD-induced body weight gain, alleviated insulin resistance, decreased serum TG, total cholesterol (TC), and alanine aminotransferase (ALT) levels, and prevented lipid deposition and apoptosis in the liver. This study showed SFA suppressed lipid deposition and apoptosis both in vitro and in vivo, indicating that SFA may be a potential candidate for preventing and treating NAFLD. Article
References:
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Li, J., Xie, S., & Teng, W. (2021). Sulforaphane attenuates nonalcoholic fatty liver disease by inhibiting hepatic steatosis and apoptosis. Nutrients, 14(1), 76. Article
Yours as always,
Dohrea
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Green Facts:
And more on broccoli sprouts: Fahey, J. W., & Kensler, T. W. (2021). The Challenges of Designing and Implementing Clinical Trials With Broccoli Sprouts… and Turning Evidence Into Public Health Action. Frontiers in Nutrition, 8, 183. Read the article: Article |
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