The Power Behind Phyto Power: The Hormetic Mechanism

The hormetic mechanism of phyto-nutrients is an exciting area of research. Scientists have discovered that small amounts of phytochemicals offer much more than nutrients. Phytochemicals offer a hormetic mechanism; a stimulation of many pathways in our body that prevents, repairs, or reverses aging and disease (Lee et al., 2014; Davinelli et al., 2012).

The concept of hormesis is defined as an adoptive response of cells and organism to low dosages of phytochemicals. This adoptive response stimulates a beneficial effect in the body (Mattson, 2008, 2008a). Calabrese et al. conducted many studies on hormetic phytochemicals and vitagenes in aging and longevity, including the effect of antioxidants such as polyphenols on neuro-generation (2012, 2011, 2009). The vitagene network of genes involved in the process of repair and maintenance is thought of as the longevity assurance processes (Rattan, 1998; see also Cornelius et al., 2013; Calabrese et al., 2010; Rattan, 2010; 2004).

Phyto Power is comprised of several species of wildcrafted blueberries, Rose hip, and Dandelion, including their leaves, stems, roots, and flowers. Growing wild and strong in remote areas of Alaska, these berries and plants are handpicked at the peak of their phytonutrient potential. For centuries, indigenous tribes of Alaskan Natives have used these power-filled berries and plants for their daily nourishment as well as ceremonial and medicinal purposes.

• Three species of Rosehip, wildcrafted, whole fruit and seeds (100% w/w), refractory dried, three Rosa species, 200mg per capsule.
• Four species of Dandelion, wildcrafted, aerial parts (90% w/w), root (10% w/w) with flower, refractory dried, four Taraxacum species, 200mg per capsule.
• Four species of Blueberry, wildcrafted, fruit (>90% w/w), leaves and stem (<5% w/w), refractory dried, four Vaccinium species, 100mg per capsule.

Phyto Power

Phyto Power

We suggest 1-2 capsules a day in the morning.

References:

• Calabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Iavicoli, I., Di Paola, R., Koverech, A. … Calabrese, E.J. (2012).Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta, 1822(5), 753-83. DOI: 10.1016/j.bbadis.2011.11.002
• Calabrese, V., Cornelius, C., Cuzzocrea, S., Iavicoli, I., Rizzarell,i E., Calabrese, E.J. (2011). Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity. Mol Aspects Med, 32 (4-6):279-304. DOI: 10.1016/j.mam.2011.10.007
• Calabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Calabrese, E.J., Mattson, M.P. (2010). Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal, 13(11), 1763-811. DOI: 10.1089/ars.2009.3074
• Calabrese, V., Cornelius, C., Mancuso, C., Barone, E., Calafato, S., Bates, T., Rizzarelli, E., Kostova, A.T. (2009). Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases.Front Biosci, 14, 376-397. Abstract
•  Davinelli, S., Willcox, D.C., & Scapagnini, G. (2012). Extending healthy aging: nutrient sensitive pathway and centenarian population. Immun Ageing, 9, 9. DOI: 10.1186/1742-4933-9-9.
• Lee, J., Jo, D.G., Park, D., Chung, H.Y., Mattson, M.P. (2014). Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system.
• Mattson, M.P. (2008). Hormesis defined. Ageing Res Rev, 7(1), 1-7. doi: 10.1016/j.arr.2007.08.007
• Mattson M.P. (2008). Dietary factors, hormesis and health. Ageing Res Rev, 7(1), 43-48. doi: 10.1016/j.arr.2007.08.004
• Rattan SI. (2008).Hormesis in aging. Ageing Res Rev, 7(1), 63-78. DOI: 10.1016/j.arr.2007.03.002
• Rattan, S.I. (1998). The nature of gerontogenes and vitagenes: Antiaging effects of repeated heat shock on human fibroblasts. Annals of the New York Academy of Sciences, 854, 54-60. doi:10.1111/j.1749-6632.1998.tb09891.x

Yours as always,

Dohrea 

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

More Research:

Large review on brain health: Soveid, N., Barkhidarian, B., Moradi, S., Gholami, F., Rasaei, N., Himmerich, H., & Mirzaei, K. (2023). The Potential Effect of Blueberry on Cognitive Health and Mood State Based on Human Intervention Studies: Systematic Review and Mini Meta-Analysis. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders).

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