The Ultimate Manager of Energy in the Body: AMPK
When 3000 scientists cite the same article, I listen.
Especially when the topic is about energy, and the ultimate system that turns it on or turns it off - a switch - which is how Herzig & Shaw (2018) describe AMPK and its various functions.
AMPK is depicted as the guardian of metabolism and mitochondrial homeostasis - a huge responsibility - after all, there are between 50-100 trillion cells in the body, and 200 different kinds of cells (Newman, 2023).
Imagine the intricate workings of every cell: maintaining the integrity of their structure, growth, apoptosis (removal of dead cells), metabolism, regulation of temperature, transportation, reproduction, and yes, communication (and not only by neurons) with other cells via enzymes, hormones, and more.
You can imagine the process required to generate energy in every cell to perform all these complicated and life sustaining duties. And also the amazing work of balancing of the energy (ATP) required to do these functions - increase or generate ATP or decrease the consumption of ATP (Newman, 2023).
One of the reasons scientific research has been focused on AMPK activation is that AMPK has shown to have tumor suppressive properties, by possibly inhibiting tumor cell growth (Herzig & Shaw, 2018). You can see now the reason so many scientists have been reading and citing this article, it is foundational for therapeutic applications.
There is so much more that AMPK does.
Stress, of course, suppresses our ability to create ATP, and it is the reason AMPK must phosphorylates key ingredients that are involved in different pathways - all to restore energy balance
We will continue this discussion in the next few weeks - as energy, or lack thereof, is one of the reason people go to see their doctor.
Meanwhile, let's keep in mind that to produce energy, our body does need to have very specific nutrients, and consistently so.
Enjoy the Article.
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References:
- Herzig, S., & Shaw, R. J. (2018). AMPK: guardian of metabolism and mitochondrial homeostasis. Nature reviews Molecular cell biology, 19(2), 121-135. Article
- Khan, Y. S., & Farhana, A. (2020). Histology, cell.
- Newman, T. (2023, December 19). What is a Cell? Medical News Today. Article
Yours as always,
Dohrea
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