Chromium: Decreasing Oxidative Stress in Diabetes Mellitus
I have been looking at recent research on Chromium, and in particular, I thought to present this great review article, meticulously researched to show how chromium decreases oxidative stress in diabetes mellitus (Kooshki et al., 2021).
We'll take a closer look this coming week and enjoy the excellent science on chromium and the way we can utilize it for our health.
Enjoy!
Abstract
Diabetes mellitus is a metabolic disorder defined as an increase in blood glucose levels (hyperglycaemia) and insufficient production or action of insulin produced by the pancreas. Chronic hyperglycaemia leads to increased reactive oxygen species (ROS) production and oxidative stress, which consequently results in insulin resistance, beta cell degeneration, dyslipidaemia, and glucose intolerance in diabetic patients. Chromium has an essential role in the metabolism of proteins, lipids, and carbohydrates through increasing insulin efficiency. This systematic review aimed to evaluate chromium supplementation's potential roles in oxidative stress indices in diabetes mellitus. A systematic search was performed in PubMed, Scopus, Google Scholar, Cochrane, and Science Direct databases until November 2020. All clinical trials and animal studies that assessed chromium's effect on oxidative stress indices in diabetes mellitus and were published in English-language journals were included. Finally, only 33 out of 633 articles met the required criteria for further analysis. Among 33 papers, 25 studies were performed on animals, and eight investigations were conducted on humans. Twenty-eight studies of chromium supplementation lead to reducing oxidative stress indices. Also, 23 studies showed that chromium supplementation markedly increased antioxidant enzymes' activity and improved levels of antioxidant indices. In conclusion, chromium supplementation decreased oxidative stress in diabetes mellitus. However, further clinical trials are suggested in a bid to determine the exact mechanisms. Article
Yours as always,
Dohrea
References
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Kooshki, F., Tutunchi, H., Vajdi, M., Karimi, A., Niazkar, H. R., Shoorei, H., & Pourghassem Gargari, B. (2021). A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review. Clinical and Experimental Pharmacology and Physiology, 48(3), 291-309. Article
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My Research: Peace and a word on Metaphysics
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Last year I wrote that Kant’s (1785) Categorical Imperative is futuristic and impressive: “act only on that maxim through which you can at the same time will that it should become a universal law” (KA 4: 421). Even in the midst of wars, political chaos, and authoritative rulers of the 18th century, and against the popularity of Hobbesian thesis of anarchy in the international system, Kant formulated the Categorical Imperative. The core intention for the supreme moral law is quite simple: “to realize freedom.” Freedom is one of these unchangeable laws, but why? |
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Metaphysics, as we have learned, is beyond this changeable world, it is about things that do not change.