Sulforaphane Reduces Severity of Psoriasis

In this brand new 2022 research, Du et al. analyzed the therapeutic effect of Sulforaphane on psoriasis and lupus erythematosus (SLE).

Both psoriasis and SLE are inflammatory and autoimmune diseases typically treated with drug therapy with many unwanted side effects.

Checking Sulforaphane ability to reduce psoriasis and help renal damage in lupus was the goal of this research. 

Mice were induced with psoriasis like condition were injected with Sulforaphane before inducing psoriasis-like condition and after using the cream on a shaved patch on their backs. 

The research measured markers, organs, and the look and feel of skin. The findings are significant: Sulforaphane reduced psoriasis and alleviated renal damage in lupus prone mice. 

My summary here is very short and to the point - but I suggest you go over the article, even quickly, just to see the different measurements and effects of the Sulforaphane. It is a very encouraging article! 

Abstract

Background: Sulforaphane, which is found in cruciferous vegetables, has been reported to have anti-inflammatory, antioxidant, and antitumour activities. However, whether sulforaphane has therapeutic effects on inflammatory or autoimmune skin diseases, including psoriasis and systemic lupus erythematosus (SLE), is unclear.

Methods: The therapeutic effects of sulforaphane were analyzed in Imiquimod (IMQ)-induced psoriasis-like mice and lupus-prone MRL/lpr mice. In IMQ-induced psoriasis-like mice treated with sulforaphane (55.3 and 110.6 μmol/kg) or vehicle control, the pathological phenotypes were assessed by the psoriasis area and severity index (PASI) score, haematoxylin-eosin staining (H&E) and quantifying of acanthosis and dermal inflammatory cell infiltration. The proportions of T cell subsets in draining lymph nodes (dLNs) and spleens were examined by flow cytometry. In MRL/lpr mice treated with sulforaphane (82.9 μmol/kg) or vehicle control, mortality and proteinuria were observed, and the glomerular pathology was examined by H&E staining. C3 and IgG depositions in kidney sections were examined by immunofluorescence staining. The proportions of plasma cells, follicular helper T (Tfh) cells, neutrophils and dendritic cells in the dLNs and spleens were examined by flow cytometry. Finally, we examined the Malondialdehyde (MDA) concentration by thiobarbituric acid reactive substance assay and the expression of Prdx1, Nqo1, Hmox1, and Gss by reverse transcription-quantitative polymerase chain reaction (RT-qPCR).

Results: Sulforaphane ameliorated the skin lesions in IMQ-induced psoriasis-like mice and the renal damage in lupus-prone MRL/lpr mice. In IMQ-induced psoriasis-like mice, sulforaphane reduced the proportions of Th1 and Th17 cells and increased the expression of antioxidant gene Prdx1. In lupus-prone MRL/lpr mice, sulforaphane increased the lifespan and the expression of Prdx1, and decreased the proportions of plasma cells, Tfh cells, neutrophils, and dendritic cells in the dLNs and spleens and the concentration of MDA.

Conclusion: Sulforaphane has significant therapeutic effects on IMQ-induced psoriasis-like mice and lupus-like MRL/Lpr mice by reducing inflammatory and autoimmune-related cells and oxidative stress. These findings provide new evidence for developing natural products to treat inflammatory and autoimmune diseases. Article

Glucosinolates & Sulforaphanes  

Each of our vegan capsule has 500 mg of organic broccoli sprouts, harvested at the peak of their phytonutrient power. 

Suggested dose: 1-2 capsules a day, preferably before going to sleep.

References:

• Du, P., Zhang, W., Cui, H., He, W., Lu, S., Jia, S., & Zhao, M. (2022). Sulforaphane Ameliorates the Severity of Psoriasis and SLE by Modulating Effector Cells and Reducing Oxidative Stress. Frontiers in pharmacology, 13, 805508-805508. Article

  Sincerely yours,

Dohrea

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

And more on broccoli sprouts: Du, P., Zhang, W., Cui, H., He, W., Lu, S., Jia, S., & Zhao, M. (2022). Sulforaphane Ameliorates the Severity of Psoriasis and SLE by Modulating Effector Cells and Reducing Oxidative Stress. Frontiers in pharmacology, 13, 805508-805508. Article

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