The No 7 Systemic Booster: The New Longevity is a serious, uncompromisingly healthy drink.
There are no sweeteners, fillers, or natural flavors to muck up the real power of the blend. It is unapologetically filled with potent ingredients that defy the sugary traditions of the health industry today. The No 7 nutrients are not sweetened or mixed with any intense sugary fruits, fillers or flavors. Typically, artificial, natural, or organic natural flavors have from 100-500 different components that are not required to be listed on the label. To healthily sweeten the palate, add some diluted organic juice like pineapple or apple, or blend with your morning shake.*
The No 7 Longevity is carefully designed to include the finest nutrients: Well researched ingredients that support and boost the major systems in the body:*
Phytonutrients- Organic strawberry, raspberry, blueberry, tart cherry, elderberry, cranberry, apple extract, pineapple, beet, kale leaves, spinach leaves, broccoli florets.
BioImmersion Super Blend: Probiotics- Bifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus, and Steprococcus thermophilus. Supernatant- probiotic metabolites, and ORNs. Prebiotics- Inulin from Chicory Root along with Fibers- from organic veggies, greens, fruits, and berries.
Nutriceuticals- Fructo Borate, Vitamin B12, Vitamin D3, Folate, Chromium.
What is longevity? What brings on the glow of a robust health in both younger and older people? According to the US National Institute of Aging (NIA), longevity is about measured strategies to extend the healthy functioning of our body (Nadon et al., 2008) – these strategies aim to prevent diseases, especially chronic illnesses like cardiovascular and cancer, among others (Caprara, 2018).*
Globally, while the average life span has increased in both developed and developing nations, in the next 30 years the aging population will double to 22%, or about 2 billion people. Since there are about 7.7 billion people in the world, this means that almost a quarter of the world will be over 60 years old. Chronic illnesses around the world are responsible for about 35 million deaths each year (United Nations, Ageing, 2017; Living Well - Dying Well, 2018, p. 119).
In the United States, 85% of people who are over 65 years of age suffer from one or two chronic illnesses, and nearly a quarter of children that are under 17 years old suffer one or more chronic conditions, with almost half of young to mature adults (18 to 64 years old) having one or more chronic illnesses (2018, Living Well - Dying Well, p. 120).
Old age causes a variety of biological and cognitive degeneration, yet the decline does not have to be debilitating. Just the opposite, with the correct approach toward prevention, healthy longevity can be achieved (Jin et al., 2015). The World health Organization (WHO) has focused their efforts on addressing non-communicable diseases, or chronic illnesses, such as cancer, ischemic heart diseases, stroke, type 2 diabetes, Alzheimer’s disease and other illnesses, as a preventative approach and a path toward longevity (WHO, 2014; see also Lim et al., 2012 global assessment of both infectious and NCDs diseases).
In the developed world, longevity was thought of as an anti-aging approach that emphasized looks rather than health. Skin care, makeup, supplements, and medicines were created to hide age and stimulate our bodies into producing more energy and higher hormone levels. Merchandise was fused with procedures to tighten or erase wrinkles and skin discolorations, sucking or adding fat, depending on the area treated, to name a few (e.g., Ganceviciene et al., 2012). Mostly, the anti-aging movement was aimed to make women look younger and men more virile.*
The No 7 New Longevity represents a comprehensive approach to health and long life (Jin et al., 2015). This new approach to longevity (or healthy ‘anti-aging’) does not solely focus on how we look but how our bodies function healthily (Fontana et al., 2014).
Key to longevity and anti-aging is the approach to calming inflammation, micro and macro inflammation, seen as the intrinsic biological aging clock (Luo et al., 2011). In 1913, Dr. Arnold Lorand seminal work, Health and Longevity through Rational Diet, explains the connection between inflammation and disease:
“The majority of the diseases with which mankind is afflicted usually creep in through the accumulated effects of successive slight irritation, by the operation of apparently insignificant factors which are you just sufficient to take part in some chemical reaction.” (p. 115)
Calder et al. (2017) characterize aging as an increase in the concentration of inflammatory markers in the blood stream, a phenomenon that has been termed “inflammageing” (see Franceschi & Campisi, 2014; Franceschi et al., 2007; Franceschi et al., 2000).*
Along with inflammation, the ageing of the immune system, called immunosenescence, is also an age-related decline of the immune system that leads to an increased frequency and severity of infectious diseases and certain cancers (Solana & Pawelec, 2004; Clements & Carding, 2016; Bauer & Fuente, 2014). Immunosenescence is brought about by a continuous chronic antigenic - toxins inducing immune response – which then overload the ability of the immune system to keep up with the demands for naïve cells, the components of cells that enable the body to fight off new, unrecognized infections or diseases (Candore et al., 2006; Calder et al., 2018).*
Once low grade chronic inflammation is activated, it becomes a system-wide condition that leads to higher mortality rates from different illnesses (e.g., Bozzetto et al., 2018; AHA, 2017; Clements & Carding, 2016; Morrisette-Thomas et al., 2014). A study on 1018 Italian old persons demonstrated that higher levels of certain inflammation-related mediators such as IL- 6, IL-1ra ,TNA-a, TNF- a receptor II (TNFAR2) were associated with higher number of chronic illnesses, such as hypertension, diabetes, ischemic heart disease, stroke, cancer, Parkinson’s, hip fractures, joint diseases, anemia, kidney disease, and cognitive impairment (Fabbri et al., 2015).*
Longevity is a balanced state of pro- and anti-inflammatory mediators. By protecting the body against the harmful effects of inflammation with high levels of anti-inflammatory molecules, long-life with better health is attainable. For example, Le Couteur et al. (2016) explain the profound effects nutrition has on ageing and longevity, with animal studies showing longevity is achieved with a specific diet that is similar to the dietary traditions of the long-lived people on the island of Okinawa – a predominantly plant based diet.*
In fact, major advances in science show we have nutrient-sensing cellular pathways that link diet and ageing (Le Couteur et al., 2016, Figure 2). Balancing the gut microbiome, avoiding foods that lead to obesity, getting enough sleep, upping whole plant carbohydrates and fibers (from vegetables, fruits, grains, seeds, and nuts), and reducing animal based protein intake, all are shown in research as interventions for extended lifespan and longevity (Vaiseman et al., 2017; Le Couteur et al., 2016; Mirzaei et al., 2014, respectively).*
Candore et al. (2006) found that when we neutralize infectious agents and live in healthy environments, we have a better chance of lowering chronic inflammatory markers in the body and protecting our immune system. Yet, in today’s toxic world, keeping inflammation down is not an easy task. In chapter 8 of Living Well, Dying Well (2018), Dr. Dohrea Bardell discusses a field of medicine that has been established to handle these complex issues - Lifestyle Medicine. Our daily routines include habits that support or detract from our health. Dr. Bardell outlines important steps we can take to improve our health, such as creating better (toxic free) environments at home and at work, changing our dietary habits by eating more plant-based foods, using natural products for personal grooming, our homes and gardens, exercising a few times a week, and more. These steps aim to lower the triggers of chronic inflammation, boost our immune system, energy level, and even sleep better. (LivingWell,DyingWell).*
A plant based dietary habits is essential (Seidelmann et al., 2018). Many scientists have come to realize that health, longevity, and anti-aging are fundamentally dependent upon the correct nutritional strategy that facilitates and educates the body’s defense, repair, adaptation, and renewal functions (Calder et al., 2017; Mykytyn, 2005; see Research tab for more articles on this topic). *
In fact, scientific research insists upon the daily consumption of plant-based foods, probiotics and their fermented metabolites, plenty of fiber, and particular nutriceuticals to achieve and sustain longevity: the healthy systemic functions of the body (Seidelmann et al., 2018; Devi & Sekhar, 2018; Filosa et al, 2018; Donoiu et al., 2018; Iskar & Antonyak, 2018; Smith & Hsu, 2018; Holscher, 2017).*
The No 7 Systemic Booster: The New Longevity is thoughtfully designed to provide a measured serving of high active nutrients from vegetables, greens, fruits, and berries, fiber, naturally whole probiotics with their metabolites, and full servings of important nutriceuticals. No 7 Systemic Booster has a definitive purpose: boosting the body’s different systems with excellent nutritious drink that is potent with ingredients shown in research to offer longevity.*
Let’s take a look at how the different ingredients work in the body. For a good jumping point, click on the Research Tab to access the global research and references to further study longevity and better health.
One of the keys to the aging process is our intestinal microbiota (Vaiseman et al., 2017). The presence of micro-organisms is actually found in the placenta and amniotic fluid (Collado et al., Nagpal et al., 2017; 2016; Arboleya et al., 2016). Stressors such as bad dietary habits, lack of exercise, toxic environments, use of antibiotics, can change the microbiota into a “dysbiosis state” that may cause different chronic diseases from immune-mediated disorders to neuropsychiatric conditions. Researchers believe that a dysbiosis state is due to alteration in the crosstalk between “commensals bacteria and intestinal epithelium, including immune cells of the gut associated lymphoid tissue (Lepage et al., 2011; Calder et al., 2017). An unfavorable balance or change in the microbiota is believed to be one of the reasons for obesity worldwide (Gao et al., 2015; Santacruz et al., 2010), an issue that affects people of all ages.
Scientists believe that dysbiosis of the gut is generated when lower diversity in the microbiota and inflammation of the gut are combined. Dysbiosis can lead to frailty (van Tongeren et al., 2005), Crohn’s (De Cruz et al., 2012), obesity and metabolic illnesses (Le Chatelier et al., 2013), colorectal cancer (Chen et al., 2012), among other conditions.
The No 7 super blend collection of naturally occurring probiotics with their supernatant and ORNs works together with plants polyphenols and fibers (as prebiotics). Probiotic microorganisms belong mostly to the following geni: Lactobacillus, Bifidobacterium, and Lactococus, Streptococcus, Enterococcus (Markowiak & Śliżewska, 2017). These foundational organisms form strong communities (ecosystems) that perform many health benefits (Nagpal et al., 2018).
For example, the Bifidobacterium have been identified as the most global inhabitants of the human host (Biavati & Mattarelli, 2006). From infancy (and even as a fetus), to adulthood and old age, health is associated with the Bifidobacterial family (Arboleya et al., 2016). In animal studies, Bifidobacterium is shown to support brain/gut axis and prevent certain types of cancers (Savignac et al., 2014, Sivan et al., 2015). Lactobacillus casei has shown in research to lower the formation of colorectal tumors (Ishikawa et al., 2005). Aging and pro-inflammation are linked ‘reduced transepithelial electric resistance’ or gut-permeability (Nicolettie, 2015). Probiotics organisms such as lactobacillus and Bifidobacterium both help to maintain a healthy microbiota which in turn halt or reverse detrimental effects of aging, strengthening intestinal barrier and the innate immune response (Nicoletti, 2015).
Research literature on age and longevity shows prolific evidence that links nutrition and gut microbiota to systemic inflammation, and suggests that dietary interventions can influence microbiota composition and diversity (Nagpal et al., 2017; Claesson et al., 2012). In fact, lower inflammation is strongly associated with vegetarian diets (or the Mediterranean diet), rich in fruits, vegetables, nuts, seeds, legumes, and whole grains, with fats from plant oils, e.g., olive oil (Calder et al., 2011; Sarubbo et al., 2018).
What about brain aging? Inflamm-aging is due in part to the increase of oxidative stress in the body and brain. Inflamm-aging is caused by a continuous antigenic load (a toxin inducing immune response) and stress which activates subclinical, chronic low-grade inflammation (Franceschi et al., 2017; 2006; Minciullo et al., 2015; Sarubbo et al., 2018). Neuro-inflammation is part of the inflamm-aging process, and is linked with decreased brain functionality, e.g., memory, learning, and coordination (Sarubbo et al., 2018). Combination of vegetables, greens, fruits, and plant fiber provide a host of rich polyphenols, shown to lower a variety of pro-inflammatory markers (Spencer et al., 2012; Hermsdorff et al., 2010; Bhupathiraju & Tucker, 2010; Holt et al., 2009). Effects of polyphenols on the body and brain include complex interaction, mediation, and activation of a variety of important biomolecules, exerting influence over cell senescence, inflammation, apoptosis, stress resistance, and metabolism (Queen & Tollefsbol, 2010) have been studied extensively for reducing oxidative stress and as anti-inflammatory and repair agents (Joseph et al., 2007; Sheridan et al., 2013; Pandey et al., 2009; Sheridan et al., 2013; Lau et al, 2005).
No 7 Longevity offers many phytonutrients from organic fruits, vegetables, greens, and plant fiber: Organic strawberry, raspberry, blueberry, tart cherry, elderberry, cranberry, apple extract, pineapple, beet, kale leaves, spinach leaves, broccoli florets.
Green leafy vegetables and vegetables such as beetroot contain dietary nitrates that mitigate many functions, such as increase energy for exercise, supplying blood and oxygen to working tissues (Kenjale et al., 2011; Lidder & Webb, 2013), blood pressure lowering (Kapil et al., 2015), and both decreasing blood pressure and improving exercise (Berry et al., 2015). Each additional serving of vegetable and fruits protect against erectile dysfunction among men with diabetes (Wang et al., 2013). Nitrates from food helps maintain brain health and function (Presley et al., 2010), and show an overall beneficial health effects, the more – the better (Hord, Tang, & Bryan, 2009).
Broccoli has high levels of glucosinolates and sulforaphanes, a potent mix of phyto-nutrient shown in research to provide phase II enzyme inducer to boost the liver’s ability to detoxify. Broccoli is also shown in research as a protective agent, offering anti-carcinogenic properties and mechanisms (Zhang et al., 1994; Zhang et al., 2015; Leon et al., 2017).
Fruits and berries: Anthocyanins from berry fruits with red, blue, or purple, enhance cognitive functions and extend neuroprotective properties (Joseph et al., 2009; Poulose & Carey, 2012). Moreover, anthocyanins can be used for inflammation-mediated conditions such as atherosclerosis (Aboonabi & Singh, 2015; Lee et al., 2014). Proanthocyanidins found in berries have also neuroprotective effects (Joseph et al., 2010).
Supplementation with dietary phytochemicals have direct and hormetic effects, balancing the pro and anti-inflammatory responses (Davinelli et al., 2015; Karlsen et al., 2007). Blueberries in particular have shown in research to improve memory in older adults (Krikorian et al., 2010; see research tab of our Blueberry-Extract for more information). Cherries and cherry juice are shown to improve memory and cognition in older adult (Kent et al., 2015). For more research on berries, see our High-ORAC as well as Phyto-Power research tabs.
The Hormetic Response:
A teaspoon of the No 7 longevity can be thought of as one veggie/fruit serving. And it can also work in small dosages called the hormetic effect or ‘preconditioning/Hormesis.’ Food phytochemicals play an emerging role as hormetic inducers of neuroprotective pathways relevant for brain aging. For example, in small portions, dietary phytochemicals from vegetables and fruits offer a stimuli that trigger adaptive stress-response mediated by NF-kB to provide neuroprotection (Davinelli et al., 2016).
Selective Nutriceuticals: The No 7 Longevity also includes patented nutriceuticals such as the Fructo Borate (125mg) and Chromium (500mcg), B12 (250mcg; as Methylcobalamin), Folate (400mcg; as 5-methyltetrahydrofolate or Quatrefolic), and Vitamin D (1000IU).
Fructo Borate is a patented natural plant-derived molecule that works effectively on systemic inflammation (and pain) for people with osteoarthritis (Scorei et al., 2011). Together with polyphenols from the vegetables, greens, fruits, and berries, Fructo Borate is potentiated for a greater bone protection (Horcjada & Offord, 2012; Shen et al., 2012). As a systemic anti-inflammation, Boron and Fructo Borate show a great potential for longevity (Nielsen, 2018).
Chromium has also been researched extensively for blood sugar regulation, weight management, and longevity (, Smith & Hsu, 2018; Iskra & Antonyak, 2018).
Vitamins B12, Folate, and D have shown in research to support many different systems in the body, from cardiovascular and metabolic diseases, brain aging, arterial function, energy, and Longevity (Ford et al., 2014; Lee et al., 2014; Fenech, 2017; Kwok et al., 2012; Thomas & Fenech, 2015; Watson et al., 2018, respectively). Check out these and more references at the Research tab of No-7-Longevity
The No 7 Longevity encompasses a great deal of research into better health. The scientific community has much more to discover, yet many of the findings do show a clear path toward health that is not riddled by chronic conditions that can be supported by a plant-based diet of whole foods, a cleaner home and office environments, exercise, toxic free personal and home cleaning products, organic or pesticides & herbicides free foods, and clean, researched based supplementations (see Living Well – Dying Well, Chapter 8).
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