Crosstalk Between Organs: The New Frontier?

Crosstalk between organs is a biological, complex, and systemic interaction between organs, and between organs and body (Battaglini et al., 2024).

In other words, our body is a huge network of communication, with the aim of preventing, maintaining, and rebuilding.  The desire of the body is to create connection and harmony, or homeostasis.

Remember from previous emails that the body is a collective of trillions of organisms and human cells (Supra Organism), so you can image the amount of communications it takes, or crosstalk, to maintain connection and harmony, or homeostasis.  

We do know when we are out of balance and cannot maintain equilibrium. What we may feel is pain or tiredness- there are many different symptoms. But behind the scenes is a different story - of communications that take place everywhere at once, through nerves and  blood vessels. A great biological effort that is in fact pure information and instruction, alongside chemical interactions 

For example, when there is a heart condition, crosstalk occurs between the heart and adipose tissue, which releases a certain chain of inflammatory chemicals (messengers like cytokines) which in turn affect the crosstalk between heart and spleen, kidneys, skeletal muscles, and adipose tissues (Jahng et al., 2016; Oishi & Manabe, 2020). 

When the brain is injured, acute neuro-inflammation causes many organs to suffer inflammation and dysbiosis, in the gut, liver, kidneys, and heart (Battaglini et al., 2024). 

Next time we will discuss crosstalk between polyphenols and gut microbiota and the effect on certain chronic diseases (i.e., Zeb et al., 2024).

Polyphenols interact with the microbiome to enact a host of activities that affects the whole body. It is a beautiful crosstalk between nutrients that five information and activate certain needed mechanism.  Read the description of No 7 Systemic Booster to learn and understand the what, why, and how of this powerhouse. 

Enjoy!

Yours as always,

Dohrea 

References

• Battaglini, D., De Rosa, S., & Godoy, D. A. (2024). Crosstalk between the nervous system and systemic organs in acute brain injury. Neurocritical Care, 40(1), 337-348. 
• Borges, A., & Bento, L. (2024). Organ crosstalk and dysfunction in sepsis. Annals of Intensive Care, 14(1), 1-11.
• Dockray, G. J. (2014). Gastrointestinal hormones and the dialogue between gut and brain. The Journal of physiology, 592(14), 2927-2941.  
• Jahng, J. W. S., Song, E., & Sweeney, G. (2016). Crosstalk between the heart and peripheral organs in heart failure. Experimental & molecular medicine, 48(3), e217-e217. Article
• Mayer, E. A. (2011). Gut feelings: the emerging biology of gut–brain communication. Nature reviews neuroscience, 12(8), 453-466.
• Montagnani, M., Bottalico, L., Potenza, M. A., Charitos, I. A., Topi, S., Colella, M., & Santacroce, L. (2023). The crosstalk between gut microbiota and nervous system: a bidirectional interaction between microorganisms and metabolome. International Journal of Molecular Sciences, 24(12), 10322.
• Oishi, Y., & Manabe, I. (2020). Organ system crosstalk in cardiometabolic disease in the age of multimorbidity. Frontiers in cardiovascular medicine, 7, 64. Article
• Yuan, W., & Song, C. (2022). Crosstalk between bone and other organs. Medical Review, 2(4), 331-348. Article
• Zeb, F., Naqeeb, H., Osaili, T., Faris, M. E., Ismail, L. C., Obaid, R. S., ... & Alam, I. (2024). Molecular crosstalk between polyphenols and gut microbiota in cancer prevention. Nutrition Research, 124, 21-42. Article

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