How Does the Brain Function with Cannabis use? (Gowin et al., 2025)
JL Gowin has lead scientific teams in the study of alcohol, sleep, and cannabis use.
His recent research just published in JAMA asked the question: Are recent cannabis use and lifetime cannabis use associated with differences in brain function cognitive task?
The research is large with 1003 young adults, (aged 22-36), both men and women, and multi cultural (Asian, African-American, Caucasian). The researchers measured using functional MRI and had participants perform 7 different tasks during the session.
The study started in 2010
The results showed a compromised brain, especially for lifetime history users, with regions of the brain that were associated with heavy use such as anterior insulation, medial prefrontal cortex and prefrontal cortex - areas in the brain for design-making, memory, including processing emotions.
The study does have limitation: it is uncontrolled (no control group to compare results), cross-sectional study (data collected occurred at a specific point in time). The heavy users may not represent severity of addiction to cannabis, and the MRI sessions were not given shortly after the use of cannabis.
We have written much about the Blueberry Extract ability to regenerate nerves and brain cells. Of course we need specific research on its effect on heavy users (or light) of cannabis, and meanwhile, the data in research on the blueberry's ability to revitalize our memory and cognition is impeccable.
Yours as always,
Dohrea
References
- Ellis, L. R., Boesch, C., & Dye, L. (2024). Effects of anthocyanins on cognition and vascular function: a systematic review. Molecular Nutrition & Food Research, 68(13), 2300502. Article
- Mayer, E. A., Horn, J., Mayer, D. E., & Randolph, E. (2024). Dietary Polyphenols to Maintain Healthier Brain Measures and Cognitive Function, as Mediated by Gut Microbiota Metabolites. In The Gut-Brain Axis (pp. 341-360). Academic Press. https://www.sciencedirect.com/science/article/abs/pii/B978032399971700014X
- Miller, M. G., Hamilton, D. A., Joseph, J. A., & Shukitt-Hale, B. (2017). Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. European Journal of Nutrition, 1-12.
- Soveid, N., Barkhidarian, B., Moradi, S., Gholami, F., Rasaei, N., Himmerich, H., & Mirzaei, K. (2022). The Potential Effect of Blueberry on Cognitive Health and Mood State Based on Human Intervention Studies: Systematic Review and Mini Meta-Analysis. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders). Abstract
- Zheng, T., Bielinski, D. F., Fisher, D. R., Zhang, J., & Shukitt-Hale, B. (2022). Protective Effects of a Polyphenol-Rich Blueberry Extract on Adult Human Neural Progenitor Cells. Molecules, 27(19), 6152. Article
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