Redefining the Heart - Gut Axis: Pathway for Health or Disease?

Heart and gut axis is getting a renewed interest in the scientific community. 

The connection between heart failure and gut dysbiosis has become more apparent and the question that scientists ask now is how to create a better homeostasis in the gut, an optimal functioning of the gut, that will positively effect heart health? (Desai et al., 2023)

The question is not only focused on the gut, although much of the research now is centered upon figuring out which organism in the gut correlates with different organs, and how. 

The body operates as a system, and hence the chosen word - axis: health is dependant upon an alliance between organs, a balance, and equilibrium. 

Wang et al. (2021) discovered that the less diverse the microbiota is (the community of organisms) in the gut, there is more increase of certain microbes that are associated with certain conditions. For example:  Certain genera are significant for the synthesizing essential amino acids in the gut (Hayashi et al., 2021), with less of them, our production of proteins is diminished. 

As with all things systemic, gut dysbiosis affects how we detox, the inflammatory markers in our blood, creating proteins (amino acids) - and all contribute to the biomarkers of heart failure (Desai et al., 2023).

There is more. Butyrate production, or lack thereof, effects atherosclerosis (Chen et al., 2020), from heart-gut to heart-kidney-gut (Sumida & Kovesdy, 2019), higher bilirubin in liver from klebsiella in the gut (Wang et al., 2021), and the list goes on: Specific negative effect of certain organs and functions in the body by organisms in the gut. 

The pathway for health and disease is not found just in the gut, that would be a mistake to isolate the gut as the epicenter of health or disease - yes, it does initiate processes that are positive or negative for the body - but it is the axis between, the connecting dots or bridge - the relationship between the gut and heart that will lead into health or disease.

We will continue to explore this relationship in the scientific literature. And meanwhile, enjoy the Beta Glucan Synbiotic: A true Heart - Gut Axis that connects exacting healthy nutrients with both the heart and the gut. 

Beta Glucan Synbiotic: Heart - Gut Axis

Yours as always,

Dohrea 

References

• Chen, W., Zhang, S., Wu, J., Ye, T., Wang, S., Wang, P., & Xing, D. (2020). Butyrate-producing bacteria and the gut-heart axis in atherosclerosis. Clinica chimica acta, 507, 236-241.
• Desai, D., Desai, A., Jamil, A., Csendes, D., Gutlapalli, S. D., Prakash, K., ... & Khan, S. (2023). Re-defining the Gut Heart Axis: A Systematic Review of the Literature on the Role of Gut Microbial Dysbiosis in Patients With Heart Failure. Cureus, 15(2). Article
• Forkosh, E., & Ilan, Y. (2019). The heart-gut axis: new target for atherosclerosis and congestive heart failure therapy. Open heart, 6(1), e000993.
• Hayashi, T., Yamashita, T., Takahashi, T., Tabata, T., Watanabe, H., Gotoh, Y., ... & Hirata, K. I. (2021). Uncovering the role of gut microbiota in amino acid metabolic disturbances in heart failure through metagenomic analysis. Frontiers in Cardiovascular Medicine, 8, 789325.
• Kamo, T., Akazawa, H., Suzuki, J. I., & Komuro, I. (2017). Novel concept of a heart-gut axis in the pathophysiology of heart failure. Korean circulation journal, 47(5), 663-669.
• Matsiras, D., Bezati, S., Ventoulis, I., Verras, C., Parissis, J., & Polyzogopoulou, E. (2023). Gut Failure: A Review of the Pathophysiology and Therapeutic Potentials in the Gut–Heart Axis. Journal of Clinical Medicine, 12(7), 2567.
• Sumida, K., & Kovesdy, C. P. (2019). The gut–kidney–heart axis in chronic kidney disease. Physiology International, 106(3), 195-206.
• Wang, Z., Cai, Z., Ferrari, M. W., Liu, Y., Li, C., Zhang, T., & Lyu, G. (2021). The correlation between gut microbiota and serum metabolomic in elderly patients with chronic heart failure. Mediators of Inflammation, 2021(1), 5587428.

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.  

My Research: International Day of Peace. 9.20.24