Energy - Energy - Energy: Foundational First Step for a Great (Correct) Detox

It is truly all about energy.

Energy to function well, to think clearly, to feel good in our bodies. Energy to enact all the different functions of each and every cell. 

Energy is one commodity that is difficult to access.

One of the major complaints is not having enough energy. 

And since AMPK is depicted as the guardian of metabolism and mitochondrial homeostasis - a huge responsibility for the 50 to 100 trillion cells in the body, with 200 different kinds of cells (Newman, 2023) - we need to pay attention.

Last summer we learned together about the importance AMPK - an activating mechanism that is in command of the energy in every cell in your body.

AMPK is AMP-activated protein kinase or 5' adenosine monophosphate-activate protein kinase. An enzyme that is a switch of a sort, or an energy sensor (Hardie et al., 2012). It actually activates ATP, which is the energy source in every cell.

The literature is filled with articles about the importance of polyphenols (Li et al., 2023; Sotoudeheian & Hoseini, 2023, Xu et al., 2023, Zang et al., 2006) and its affect on AMPK and health of liver, kidneys, energy, weight loss, fatty liver, metabolism and heart health. It is astonishing.

There is also the microbiome and its importance to maintaining a good functioning AMPK (Li et al., 2024).

For Sinclair Kennally, feeling good and maintaining a great energy level start with detox, and before detox can actually begins, restoration of energy is key! Most of us think that first we detox and then we gain energy. The reality is that we need energy to detox! 

Healing is not a linear experience - it is layered and multi dimensional pathway. Listen to our interview (it is fun!) and learn how to take a few steps in this odyssey we call life.

 Share the Power: Sinclair Kennally

Yours as always,

Dohrea 

References

• Canbolat, E., & Cakıroglu, F. P. (2023). The importance of AMPK in obesity and chronic diseases and the relationship of AMPK with nutrition: a literature review. Critical Reviews in Food Science and Nutrition, 63(4), 449-456. Abstract
• Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012). AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nature reviews Molecular cell biology, 13(4), 251-262. Article
• Fang, C., Pan, J., Qu, N., Lei, Y., Han, J., Zhang, J., & Han, D. (2022). The AMPK pathway in fatty liver disease. Frontiers in Physiology, 13, 970292. Article
• Herzig, S., & Shaw, R. J. (2018). AMPK: guardian of metabolism and mitochondrial homeostasis. Nature reviews Molecular cell biology, 19(2), 121-135. Article
• Gurd, B. J., Menezes, E. S., Arhen, B. B., & Islam, H. (2023, July). Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA. In Seminars in Cell & Developmental Biology (Vol. 143, pp. 17-27). Academic Press.
• Juszczak, F., Caron, N., Mathew, A. V., & Declèves, A. E. (2020). Critical role for AMPK in metabolic disease-induced chronic kidney disease. International journal of molecular sciences, 21(21), 7994. Article
• Khan, Y. S., & Farhana, A. (2020). Histology, cell.
• Li, H., Liang, J., Han, M., & Gao, Z. (2024). Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review. Journal of Advanced Research. Article
• Newman, T. (2023, December 19). What is a Cell? Medical News Today. Article 
• Richter, EA, Ruderman, NB.  (2009) AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J. 418(2):261-75.
• Steinberg, G. R., & Kemp, B. E. (2009). AMPK in health and disease. Physiological reviews, 89(3), 1025-1078. Article
• Sotoudeheian, M., & Hoseini, S. (2023). Therapeutic properties of polyphenols affect AMPK molecular pathway in hyperlipidemia. Article
• Xu, W., Luo, Y., Yin, J., Huang, M., & Luo, F. (2023). Targeting AMPK signaling by polyphenols: A novel strategy for tackling aging. Food & Function, 14(1), 56-73. Article
• Zang, M., Xu, S., Maitland-Toolan, K. A., Zuccollo, A., Hou, X., Jiang, B., ... & Cohen, R. A. (2006). Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor–deficient mice. Diabetes, 55(8), 2180-2191. Article

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