Role of probiotics to combat viral infections with emphasis on COVID-19

Dear Friend,

Although many people think that vaccines will offer enough protection from viral infections, the reality is that viruses mutate, and new ones emerge continually. Whether you are for or against (or in between) vaccination, it is important to understand and utilize holistic measures to boost our abilities to fight infections.

This is what many scientists, such as the team of Sundararaman et al. (2020) are actually doing – researching and analyzing supportive measures. What can help fight infections?

The review shows many scientists’ conclusion to the therapeutic role of probiotics and it is exciting to see the many uses of probiotics for the management of viruses such as corona virus-2 (SARS-CoV-2) or as we know it Covid-19, as well as the West Afrika outbreak of Ebola (Sundararaman et al., 2020).

The big questions are which probiotics and how do probiotics act as antiviral agents?  In particular, Lactobacillus, Bifidobacterium, Leuconostoc, Pediococcus, and Enterococcus were discussed with the mechanisms that prevent and treat viral infections. For example, as modulators of gut microbe and hence gut homeostasis, probiotics through the production of interferon as an antiviral mechanism. Probiotic consumption improves the level of type I interferons, antigen-presenting cells, NK cells, and T and B cells in the lungs’ immune system.

Probiotic administration can also improve the pro- and anti-inflammatory cytokines, helping to clear the viral infection by minimizing the cell damage in the lungs (Baud et al., 2020).

 Original Synbiotic

Abstract:

Interspecies transmissions of viruses between animals and humans may result in unpredictable pathogenic potential and new transmissible diseases. This mechanism has recently been exemplified by the discovery of new pathogenic viruses, such as the novel severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) pandemic, Middle-East respiratory syndrome-coronavirus epidemic in Saudi Arabia, and the deadly outbreak of Ebola in West Africa. The. SARS-CoV-2 causes coronavirus disease-19 (COVID-19), which is having a massive global impact in terms of economic disruption, and, above all, human health. The disease is characterized by dry cough, fever, fatigue, myalgia, and dyspnea. Other symptoms include headache, sore throat, rhinorrhea, and gastrointestinal disorders. Pneumonia appears to be the most common and severe manifestation of the infection. Currently, there is no vaccine or specific drug for COVID-19. Further, the development of new antiviral requires a considerable length of time and effort for drug design and validation. Therefore, repurposing the use of natural compounds can provide alternatives and can support therapy against COVID-19. In this review, we comprehensively discuss the prophylactic and supportive therapeutic role of probiotics for the management of COVID-19. In addition, the unique role of probiotics to modulate the gut microbe and assert gut homeostasis and production of interferon as an antiviral mechanism is described. Further, the regulatory role of probiotics on gut-lung axis and mucosal immune system for the potential antiviral mechanisms is reviewed and discussed. Full-Article

Sincerely yours,

Seann

References

• Baud, D., Dimopoulou Agri, V., Gibson, G. R., Reid, G., & Giannoni, E. (2020). Using probiotics to flatten the curve of coronavirus disease COVID-2019 pandemic. Frontiers in public health, 8, 186.

• Sundararaman, A., Ray, M., Ravindra, P. V., & Halami, P. M. (2020). Role of probiotics to combat viral infections with emphasis on COVID-19. Applied microbiology and biotechnology, 1-16.

  Suggested use: One teaspoon a day of the Original Synbiotic

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